32 completed, 7 unknown, 6 recruiting, 3 terminated. 56 Phase 3, 17 Phase 2.
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome Epinephrine 0.5 mg intravenous bolus, Epinephrine 1 mg intravenous bolus - Out-of-hospital Cardiac Arrest (OHCA) | Phase 3 | Not yet recruiting | Central Hospital, Nancy, France | 4336 | 2026-06-01 | 2026-03-02 |
| Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section Epinephrine (Adrenaline) bolus then infusion, Epinephrine (Adrenaline) infusion - Hemodynamic (MAP) Stability | Phase 3 | Completed | Cairo University | 80 | 2026-03-18 | 2026-08-28 |
| R.E.C.K vs Exparel in Robotic Nephrectomy Ropivacaine HCL, Exparel, Epinephrine - Renal Carcinoma, Nephrectomy / Methods | Phase 3 | Recruiting | Wake Forest University Health Sciences | 170 | 2025-11-14 | 2026-07-13 |
| FMXIN002 in Patients at Risk of Anaphylaxis Epinephrine 4mg nasal powder spray, Adrenalin 0.5mg Injectable Product - Anaphylaxis Food | Phase 2 / Phase 3 | Enrolling by invitation | Nasus Pharma | 30 | 2025-06-12 | 2025-07-01 |
| Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate: Exploring Its Role in Optimizing Surgical Outcomes TURP, Epinephrine - Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate | Phase 3 | Recruiting | Benha University | 80 | 2025-03-20 | 2026-07-29 |
| Comparison of Bupivacaine Wound Infiltration Versus Wound Instillation to Minimize Postoperative Pain After Thyroid Surgery Bupivacaine, Adrenaline, Lidocaine (drug) - Thyroid Surgery | Phase 3 | Not yet recruiting | Assiut University | 102 | 2025-03-01 | 2025-01-23 |
| Bupivacaine and Epinephrine Injection Study Sensorcaine with Epinephrine, Sham injection - Sinus Disease, Anesthesia | Phase 2 / Phase 3 | Recruiting | Amin Javer | 80 | 2024-11-15 | 2025-05-15 |
| Can PLIA Reduce Early Post-operative Pain After PAO Surgery? Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline) - Hip Dysplasia | Phase 2 / Phase 3 | Completed | Michael C Willey | 121 | 2024-10-03 | 2026-10-07 |
| Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery Epinephrine, Normal Saline irrigation fluid - Intraoperative Bleeding | Phase 3 | Withdrawn | The Guthrie Clinic | 2024-08-01 | 2024-10-15 | |
| Liposomal Bupivacaine Use in Alveolar Bone Graft Patients Liposomal Bupivacaine, Bupivacain, Epinephrine - Cleft Lip and Palate | Phase 3 | Unknown | Kerry O'Rourke | 60 | 2024-04-24 | 2024-07-03 |
| The Investigator Administers Intracoronary Adrenaline Via the Catheter in STEMI Patients During Primary PCI, After Flow Restoration and Before Stenting, and Studies Its Effect in Prevention of No Reflow Adrenaline - ST Segment Elevation Myocardial Infarction (STEMI), No Reflow Phenomenon | Phase 3 | Recruiting | Ain Shams University | 1000 | 2024-04-01 | 2025-03-11 |
| Efficacy of Liposomal Bupivacaine Post Septorhinoplasty Liposomal Bupivacaine, 0.25% bupivacaine with 1:200,000 epinephrine, Placebo - Saline solution - Rhinoplasty, Pain Management | Phase 3 | Enrolling by invitation | Jessyka Lighthall | 72 | 2024-02-05 | 2026-04-03 |
| POHCA Resuscitation: Evaluation of IM Epinephrine Epinephrine Injection - Pediatric Out-of-Hospital Cardiac Arrest | Phase 2 / Phase 3 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 284 | 2024-01-08 | 2025-03-11 |
| Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis Hypertonic Saline Solution, 1 Ml, Adrenaline - Acute Bronchiolitis Due to Respiratory Syncytial Virus | Phase 3 | Unknown | Combined Military Hospital, Pakistan | 60 | 2023-11-01 | 2024-08-22 |
| Articaine Efficacy and Safety for 3 Years Old Children Mepivacaine 2% with epinephrine 1:100,000, Articaine (4%) with epinephrine 1:100,000 - Dental Caries in Children, Dental Diseases | Phase 3 | Active not recruiting | Qassim Health Cluster | 200 | 2023-07-01 | 2024-12-27 |
| Management of Shock in Children With SAM or Severe Underweight and Diarrhea Blood and Dopamine, Blood and adrenaline - Shock Hypovolemic, Shock, Septic | Phase 3 | Recruiting | International Centre for Diarrhoeal Disease Research, Bangladesh | 135 | 2021-08-17 | 2025-04-16 |
| Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L in Children 4% Articaine Hydrochloride with 1:100,000 Adrenaline, 2% Mepivacaine Hydrochloride with 1:20,000 Levonordefrin - Local Anesthesia | Phase 3 | Completed | Cairo University | 10 | 2021-08-01 | 2023-03-14 |
| Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine by Laypersons Tumescent Lidocaine and Epinephrine - Venomous Snakebites, Local Anesthesia | Phase 2 / Phase 3 | Unknown | Jeffrey Alan Klein, MD | 36 | 2021-02-22 | 2021-02-08 |
| Efficacy of SLN Block for Chronic Cough Superior laryngeal nerve block, Injection of placebo (saline), Injection of steroid-lidocaine mixture - Cough, Superior Laryngeal Nerve Block | Phase 3 | Completed | Medical University of South Carolina | 17 | 2020-07-22 | 2025-10-23 |
| RCT of Gastric ESD With or Without Epineprhine Added Solution Endoscopic submucosal dissection, Epinephrine - Gastric Neoplasm, Early Gastric Cancer | Phase 3 | Completed | Chinese University of Hong Kong | 800 | 2020-01-10 | 2025-05-04 |
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Agnosia (7) · Pain (6) · Pain, Postoperative (6) · Heart Arrest (4) · Asthma (2) · Diabetes Insipidus (2) · Dyspnea (2) · Hemorrhage (2) · Infections (2) · Osteoarthritis (2) · Shock, Septic (2) · Blood Loss, Surgical (1) · Bronchiolitis (1) · Carcinoma, Renal Cell (1) · Cardiac Output, Low (1)
Amphastar Pharmaceuticals, Inc. (2) · Assiut University (2) · Cairo University (2) · Chinese University of Hong Kong (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Pacira Pharmaceuticals, Inc (2) · Wake Forest University Health Sciences (2) · Ain Shams University (1) · Amin Javer (1) · Assistance Publique - Hôpitaux de Paris (1) · Benha University (1) · CHA University (1) · Central Hospital, Nancy, France (1) · Centrexion Therapeutics (1) · Combined Military Hospital, Pakistan (1)
United States (19) · Canada (6) · Egypt (5) · France (4) · South Korea (3) · Singapore (2) · Sweden (2) · Bangladesh (1) · China (1) · Denmark (1) · Greece (1) · Hong Kong (1) · Iran (1) · Israel (1) · Italy (1)
Alessandro Santini, MD (1) · Ali Moshaver, MD (1) · Anil Gupta, MD, PhD (1) · Antonio Pesenti, MD (1) · Arnon Elizur, Prof. (1) · Asya A. Almansour, SBPD (1) · Atyaf A. Alhunti (1) · Bobby Bellard, MD (1) · Chad A. Purnell, MD (1) · Charis Roussos, MD, PhD (1) · Conor Mc Donnell, MD (1) · Courtney Tipton (1) · Djillali Annane, MD, PhD (1) · Elisabeth Stadberg, MD (1) · Eric Bellissant, MD, PhD (1)
PMID 22900785, PMID 31959019, PMID 10371570, PMID 12675760, PMID 12873949, PMID 1517644, PMID 15919269, PMID 1632474, PMID 17341537, PMID 17470271, PMID 17720019, PMID 19593244, PMID 19841339, PMID 19884591, PMID 19953579, PMID 21615299, PMID 21627690, PMID 22013534, PMID 22227789, PMID 22353644, PMID 23049275, PMID 23496872, PMID 23860985, PMID 24196006, PMID 24661049, PMID 25452661, PMID 25866297, PMID 25912739, PMID 26308513, PMID 26323041, PMID 26440279, PMID 26447431, PMID 26507422, PMID 26821696, PMID 27042786, PMID 27549684, PMID 27673385, PMID 27787269, PMID 27790554, PMID 28144779, PMID 28316439, PMID 28470580, PMID 28509730, PMID 28562541, PMID 29265171, PMID 29318195, PMID 30065491, PMID 30243062, PMID 30904852, PMID 31136331
2014 (2), 2015 (1), 2023 (1)