19 completed, 2 recruiting, 2 terminated, 2 unknown. 22 Not applicable, 3 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Completed 16, Recruiting 2, Terminated 2, Active not recruiting 1, Unknown 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 2 | 1 | Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow dark chocolate: new trials by email Literature Review of dark chocolate trials Research Report on dark chocolate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Chocolate Consumption Prior to Prolonged Sitting on Cardiovascular Health in Young Women dark chocolate, Milk Chocolate, White Chocolate - Cardiovascular Health During Prolonged Sitting | Not applicable | Recruiting | King Saud University | 22 | 2026-04-04 | 2026-10-07 |
| Effect of Maternal Chocolate Consumption on Fetal Non-Stress Test (NST) Reactivity. Dark Chocolate, Sugar-free White Chocolate - Fetal Distress | Not applicable | Recruiting | Universidad Nacional Autonoma de Honduras | 190 | 2026-02-15 | 2026-03-03 |
| Theobromine From Cocoa and Cardiovascular Risk Factors dark chocolate, white chocolate - Hypertension | Not applicable | Completed | Chiang Mai University | 53 | 2025-02-15 | 2026-03-18 |
| The Effect of Dark Chocolate and Cinnamon Sugars on Pain and Anxiety in University Students With Primary Dysmenorrhea Cinnamon sugar, Dark chocolate - Primary Dysmenorrhea, Pain | Not applicable | Completed | Trakya University | 35 | 2024-03-30 | 2025-05-20 |
| The Cardiovascular Benefits of Resistance Training and Dark Chocolate in Female Adults dark chocolate, milk chocolate, high-intensity resistance exercise - Vascular Function in Healthy Volunteers | Not applicable | Completed | National Cheng Kung University | 31 | 2023-09-01 | 2025-04-04 |
| Short-term Cocoa Supplementation and Elite Soccer Players dark chocolate, White chocolate - Dyslipidemias, Fatty Acid; Metabolic Disorder | Not applicable | Completed | University of Padova | 38 | 2023-05-03 | 2023-10-10 |
| Renal Ultrasound Response After Chocolate Consumption Dark chocolate, White chocolate - Chocolate Consumption | Not applicable | Completed | Gregoire Wuerzner; MD | 33 | 2023-02-22 | 2026-06-29 |
| Chocolate Dynamic Vessel Analysis Dark chocolate, Milk Chocolate - Retinal Vascular | Not applicable | Completed | Querques Giuseppe | 20 | 2021-04-09 | 2025-03-12 |
| The Effect of Dark Chocolate Consumption on Blood Parameters in Healthy Adult Individuals Dark Chocolate - Cardiovascular Diseases | Not applicable | Completed | Eastern Mediterranean University | 37 | 2020-12-20 | 2022-03-22 |
| Dark Chocolate and Glucose Levels in Diabetes Dark chocolate - Type 2 Diabetes, Type 1 Diabetes | Not applicable | Completed | University of British Columbia | 14 | 2020-11-20 | 2025-02-27 |
| Chocolate for Patients With Chronic Kidney Disease Dark Chocolate - Chronic Kidney Disease | Not applicable | Completed | Universidade Federal Fluminense | 59 | 2020-10-30 | 2024-03-22 |
| Dark Chocolate and Exercise Performance in Hypoxia Dark chocolate, Placebo - Hypoxia | Not applicable | Completed | University of Saskatchewan | 12 | 2019-05-15 | 2020-06-11 |
| Dark Chocolate, Cholesterol and Microbiota Dark Chocolate - Dyslipidemias, Hypertriglyceridemia | Not applicable | Unknown | University of Bari | 40 | 2019-05-01 | 2019-04-17 |
| The Effect of High Antioxidant Cacao on Behaviors in Children With Autism Spectrum Disorder Dark Chocolate - Autism Spectrum Disorder | Not applicable | Terminated | Loma Linda University | 16 | 2017-11-14 | 2021-06-02 |
| The Effects of Dark Chocolate (70% Cacao) on EEG Brain Waves in Vigorously Active Individuals dark chocolate, non dark chocolate - Healthy | Not applicable | Completed | Loma Linda University | 10 | 2017-09-05 | 2018-06-25 |
| Impact of Dark Chocolate on Visual Performance Dark chocolate, Milk Chocolate - Dietary Supplementation | Not applicable | Completed | University of the Incarnate Word | 57 | 2017-06-25 | 2019-04-18 |
| ChOcolate COnsumption And Blood Pressure (COCOA-BP): A Wearable Devices Pilot Trial Dark Chocolate, Wearable devices - Health Behavior, Blood Pressure | Not applicable | Completed | Boston Scientific Corporation | 67 | 2016-09-16 | 2017-10-04 |
| The Effects of Dark Chocolate on Blood Pressure in Individuals With Mildly Elevated Blood Pressure Dark chocolate, Dietary counselling - Blood Pressure | Not applicable | Completed | University of Helsinki | 30 | 2012-11-01 | 2014-05-05 |
| Effects of Dark Chocolate on the Risk Factors of Cardiovascular Diseases White chocolate, Dark chocolate - Cardiovascular Diseases | Not applicable | Active not recruiting | San Diego State University | 45 | 2011-04-01 | 2026-02-05 |
| Effects of Acute Ingestion of Dark Chocolate on Endothelial Function in Hypertensive Patients Dark chocolate - Hypertension | Phase 4 | Completed | Hospital Universitario Pedro Ernesto | 21 | 2011-01-01 | 2012-01-11 |
Showing 20 of 26. Sign in to see all of them.
Hypertension (5) · Cardiovascular Diseases (2) · Dyslipidemias (2) · Renal Insufficiency, Chronic (2) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · Esophageal Achalasia (1) · Fetal Distress (1) · Health Behavior (1) · Hypertriglyceridemia (1) · Hypoxia (1) · Metabolic Diseases (1) · Pain (1)
Loma Linda University (2) · Société des Produits Nestlé (SPN) (2) · Boston Scientific Corporation (1) · Chiang Mai University (1) · Eastern Mediterranean University (1) · Gregoire Wuerzner; MD (1) · Hospital Universitario Pedro Ernesto (1) · King Saud University (1) · National Cheng Kung University (1) · Querques Giuseppe (1) · San Diego State University (1) · Tel-Aviv Sourasky Medical Center (1) · Trakya University (1) · Universidad Nacional Autonoma de Honduras (1) · Universidad de Antioquia (1)
United States (4) · Italy (3) · Switzerland (3) · Brazil (2) · Canada (2) · Turkey (Türkiye) (2) · Colombia (1) · Finland (1) · Germany (1) · Honduras (1) · Saudi Arabia (1) · Taiwan (1) · Thailand (1)
Gary Williamson, PhD (2) · Karen A Cooper, PhD (2) · Abdullah B Alansare, PhD (1) · Antonio Paoli, MD (1) · Cheng-Shiun He Professor (1) · Dirk Taubert (1) · Francesco Bandello, MD (1) · Georgia Hodgkin, EdD (1) · Jeff C Rabin, OD, MS, PhD (1) · Kongsak Boonyapranai, Doctoral degree (1) · Lee Berk, DrPH (1) · Menno Pruijm, PD MD (1) · Mikael Fogelholm, Dr. (1)
PMID 17609490, PMID 26296850, PMID 29710322, PMID 35852625, PMID 36657913, PMID 39215063, PMID 39562414, PMID 40020766, PMID 40249472