6 recruiting, 5 active not recruiting, 5 not yet recruiting, 4 unknown. 24 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 24 | Active not recruiting 5, Not yet recruiting 5, Recruiting 5, Completed 3, Unknown 3, Enrolling by invitation 2, Terminated 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Cryoneurolysis: new trials by email Literature Review of Cryoneurolysis trials Research Report on Cryoneurolysis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cryoneurolysis for Abdominal Wall Relaxation Prior to Ventral Hernia Repair Cryoneurolysis - Ventral Hernia, Incisional Hernia | Not applicable | Not yet recruiting | University of South Florida | 10 | 2026-11-01 | 2026-10-15 |
| Comparison Between Radiofrequency,Hydrodissection and Cryoneurolysis in Chronic Ankle Pain Radiofrequency ablation, Hydrodissectipn with botilonum toxin, Cryoneurolysis - Chronic Ankle Pain in Athletes | Not applicable | Not yet recruiting | Assiut University | 87 | 2026-10-20 | 2026-08-21 |
| FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy Intercostal Nerve Cryoablation - Pulmonary Dysfunction, Median Sternotomy Recovery | Not applicable | Not yet recruiting | Rutgers, The State University of New Jersey | 100 | 2026-07-15 | 2026-06-09 |
| Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis Cryoneurolysis, pulsed radiofrequency (RF), cooled radiofrequency - Knee Osteoarthritis | Not applicable | Recruiting | Tanta University | 30 | 2026-06-10 | 2026-08-11 |
| Cryoneurolysis in Patients Awaiting Total Hip and Knee Arthroplasty Cryoneurolysis - Hip Arthropathy, Knee Arthropathy | Not applicable | Not yet recruiting | University of Calgary | 30 | 2026-06-01 | 2026-05-04 |
| Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities Cryoneurolysis, Botulinum toxin - Centreal Neurological Condition, Acquired Brain Injury (Including Stroke) | Phase 4 | Recruiting | Oxford University Hospitals NHS Trust | 50 | 2025-12-02 | 2025-12-26 |
| Cryoneurolysis for Painful Diabetic Neuropathy of the Foot cryoneurolysis, sham cryoneurolysis - Painful Diabetic Peripheral Neuropathy (PDPN) | Not applicable | Active not recruiting | University of California, San Diego | 30 | 2025-08-25 | 2026-07-06 |
| Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System Cryoneurolysis - Spasticity as Sequela of Stroke | Not applicable | Recruiting | Sue Peters | 25 | 2025-08-01 | 2026-04-21 |
| Cryoneurolysis of the Suprascapular Nerve for Perioperative Pain Control After Receiving a Reverse Total Shoulder Arthroplasty (RTSA) Cryoneurolysis, No cryoneurolysis - Degenerative Joint Disease of Shoulder | Not applicable | Recruiting | North Texas Medical Research Institute, PLLC | 20 | 2025-07-30 | 2025-08-15 |
| Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain iovera system, Radiofrequency ablation alone - Chronic Low-back Pain | Not applicable | Active not recruiting | University of Kansas Medical Center | 30 | 2025-05-13 | 2026-10-08 |
| Cryoneurolysis vs Radiofrequency Ablation for Chronic Sacroiliac Joint Pain Cryoneurolysis, Radiofrequency ablation - Chronic Sacroiliac Joint Pain | Not applicable | Not yet recruiting | Medical Pain Management Services, PLLC | 30 | 2025-05-01 | 2025-04-20 |
| A Study Investigating Peripheral Cryoneurolysis in Adults With Chronic Migraine Cryoneurolysis - Chronic Migraine | Not applicable | Active not recruiting | St. Olavs Hospital | 12 | 2024-08-29 | 2026-08-26 |
| The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction Cryoneurolysis - ACL Repair | Not applicable | Recruiting | Virtua Health, Inc. | 20 | 2024-08-28 | 2026-05-12 |
| Cryoneurolysis for Acute Postoperative Pain Following Total Knee Arthroplasty Cryoneurolysis, Sham - Acute Postoperative Pain | Not applicable | Unknown | Copenhagen University Hospital, Hvidovre | 44 | 2024-03-19 | 2024-07-16 |
| A Study to Investigate the Efficacy of Pain Reduction With Cryoneurolysis Compared With Sham-treatment in Adults With Trigeminal Neuralgia Cryoneurolysis, Stimulation - Trigeminal Neuralgia | Not applicable | Active not recruiting | St. Olavs Hospital | 24 | 2024-02-29 | 2026-08-26 |
| Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma Cryoneurolysis, Local anesthetic peripheral nerve block, Sham Cryoneurolysis - Rib Fracture, Rib Fracture Multiple | Not applicable | Enrolling by invitation | University of California, San Diego | 120 | 2023-10-30 | 2026-08-24 |
| UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture Cryoneurolysis, Sham Cryoneurolysis - Rib Fractures, Rib Fracture Multiple | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 24 | 2023-10-23 | 2025-09-12 |
| Cryoneurolysis Prior to Total Knee Arthroplasty Cryoneurolysis, Sham - Post Operative Pain, Knee Osteoarthritis | Not applicable | Active not recruiting | Esbjerg Hospital - University Hospital of Southern Denmark | 100 | 2023-08-30 | 2026-10-13 |
| Cryoneurolysis for Knee and Shoulder Pain in an Inpatient Setting Cryoneurolysis - Shoulder Pain, Knee Pain | Unknown | Vancouver Island Health Authority | 25 | 2022-10-10 | 2024-06-14 | |
| Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Postoperative Pain After Mastectomy Cryoneurolysis, Sham Comparator - Mastectomy; Lymphedema | Not applicable | Enrolling by invitation | University of California, San Diego | 216 | 2022-09-15 | 2026-08-24 |
Showing 20 of 26. Sign in to see all of them.
Pain (4) · Rib Fractures (4) · Chronic Pain (3) · Osteoarthritis, Knee (3) · Pain, Postoperative (3) · Low Back Pain (2) · Muscle Spasticity (2) · Stroke (2) · Accidental Injuries (1) · Acute Pain (1) · Brain Injuries (1) · Fractures, Bone (1) · Hernia (1) · Hernia, Abdominal (1) · Hernia, Ventral (1)
University of California, San Diego (5) · Esbjerg Hospital - University Hospital of Southern Denmark (2) · St. Olavs Hospital (2) · Aarhus University Hospital (1) · Assiut University (1) · Copenhagen University Hospital, Hvidovre (1) · Medical Pain Management Services, PLLC (1) · North Texas Medical Research Institute, PLLC (1) · Oxford University Hospitals NHS Trust (1) · Rutgers, The State University of New Jersey (1) · Stanford University (1) · Sue Peters (1) · Sunnybrook Health Sciences Centre (1) · Tanta University (1) · University of Aarhus (1)
United States (11) · Denmark (5) · Canada (3) · Norway (2) · Egypt (1) · United Kingdom (1)
Carsten Kock-Jensen, MD (2) · Anders H Springborg, MD (1) · Ben Safa, MD (1) · Brian Ilfeld, MD, MS (1) · Brian M Ilfeld, MD, MS (1) · Daniel F Bratbak, PhD (1) · Joseph D Forrester, MD (1) · Kaare Meier, MD, Ph.D (1) · Lone Nikolajsen, M.D, Prof. (1) · Martin Ferrillo, DO (1) · Maurits Van Tulder, Prof. (1) · Mohammad U Burney, MD (1) · Monica Polcz, MD (1)
PMID 23279331, PMID 28336454, PMID 33279353, PMID 33637085, PMID 34011351, PMID 36385136, PMID 38724261, PMID 41700907, PMID 41870345
2025 (1)