28 completed. 28 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 28 | Completed 28 |
| Phase 2 | 4 | Completed 4 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3) Colchicine, Placebo colchicine - Ischemic Stroke, TIA | Phase 3 | Completed | Beijing Tiantan Hospital | 8343 | 2022-08-11 | 2024-06-25 |
| Effect of Colchicine on the Progression of Aortic Valve Stenosis - A Pilot Study Colchicine 0.6 mg, Placebo - Aortic Stenosis, Inflammation | Phase 2 / Phase 3 | Completed | Ottawa Heart Institute Research Corporation | 24 | 2022-07-01 | 2026-05-06 |
| Colchicine for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement Colchicine, Placebo - Transcatheter Aortic Valve Replacement, Atrial Fibrillation New Onset | Phase 3 | Completed | Insel Gruppe AG, University Hospital Bern | 120 | 2021-09-21 | 2026-06-03 |
| Randomized Double-blind Trial to Study the Benefit of Colchicine in Patients With Acutely Decompensated Heart Failure Colchicine 0.5 MG, Placebo - HEART FAILURE | Phase 3 | Completed | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | 279 | 2021-02-08 | 2024-05-22 |
| Survival TRial Using CytoKines in COVID-19 (STRUCK Trial) Ixekizumab, Aldesleukin, Colchicine - Covid19 | Phase 3 | Completed | University of Sao Paulo | 60 | 2021-01-05 | 2022-07-28 |
| Study to Investigate the Treatment Effect of Colchicine in Patients With COVID-19 Colchicine, Standard COVID-19 care - COVID-19 | Phase 3 | Completed | Ayub Teaching Hospital | 102 | 2020-12-01 | 2023-01-05 |
| Colchicine/Statins for the Prevention of COVID-19 Complications (COLSTAT) Trial Standard of Care (SOC) and Colchicine+Rosuvastatin - SARS-CoV-2 | Phase 3 | Completed | Yale University | 250 | 2020-10-30 | 2023-04-27 |
| PREEMPTIVE THERAPY WITH COLCHICINE IN PATIENTS OLDER THAN 60 YEARS WITH HIGH RISK OF SEVERE PNEUMONIAE DUE TO CORONAVIRUS Colchicine plus symptomatic treatment (paracetamol), Symptomatic treatment (paracetamol or best symptomatic treatment based on doctor recommendations) - SARS-CoV-2 Infection (COVID-19) | Phase 3 | Completed | Instituto de Investigación Marqués de Valdecilla | 70 | 2020-08-19 | 2023-11-08 |
| Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia Emtricitabine/tenofovir, Colchicine Pill, Rosuvastatin - COVID-19 | Phase 2 / Phase 3 | Completed | Universidad Nacional de Colombia | 650 | 2020-08-18 | 2021-08-12 |
| Trial to Study the Benefit of Colchicine in Patients With COVID-19 Colchicine Tablets, Standard therapy for COVID-19 according to the stablished hospital protocols. - COVID19 | Phase 3 | Completed | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | 102 | 2020-04-30 | 2021-01-12 |
| Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial Colchicine, Interferon-Beta, Aspirin - Coronavirus, Severe Acute Respiratory Syndrome | Phase 3 | Completed | Population Health Research Institute | 6667 | 2020-04-21 | 2024-01-11 |
| The ECLA PHRI COLCOVID Trial. Effects of Colchicine on Moderate/High-risk Hospitalized COVID-19 Patients. Colchicine, Local standard of care - COVID-19 | Phase 3 | Completed | Estudios Clínicos Latino América | 1279 | 2020-04-17 | 2021-04-27 |
| The Effect of Colchicine on Inflammation in ACS Patients Colchicine Tablets - Acute Coronary Syndrome, STEMI | Phase 3 | Completed | Ain Shams University | 88 | 2020-02-01 | 2023-09-26 |
| Impact of Short-course Colchicine Versus Placebo After Pulmonary Vein Isolation (IMPROVE-PVI Pilot) Colchicine 0.6 mg, Matching placebo - Atrial Fibrillation, Recurrence | Phase 3 | Completed | Population Health Research Institute | 202 | 2020-01-14 | 2024-09-19 |
| Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry Colchicine, Spironolactone, SYNERGY Bioabsorbable Polymer Drug-Eluting Stent - ST Elevation Myocardial Infarction, Non ST Elevation Myocardial Infarction | Phase 3 | Completed | Population Health Research Institute | 7264 | 2018-02-01 | 2024-10-15 |
| Colchicine for Prevention of Vascular Inflammation in Non-cardio Embolic Stroke Colchicine - Ischemic Attack, Transient, Stroke | Phase 3 | Completed | University College Dublin | 3154 | 2016-12-12 | 2025-03-13 |
| Colchicine Cardiovascular Outcomes Trial (COLCOT) colchicine, colchicine placebo - Coronary Artery Disease, Myocardial Infarction | Phase 3 | Completed | Montreal Heart Institute | 4745 | 2015-12-04 | 2020-10-19 |
| Colchicine in Atrial Fibrillation to Prevent Stroke Colchicine, Placebo - Atrial Fibrillation, Stroke | Phase 3 | Completed | Population Health Research Institute | 80 | 2014-11-01 | 2021-02-23 |
| Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout Febuxostat IR, Febuxostat XR, Febuxostat placebo - Gout | Phase 3 | Completed | Takeda | 1790 | 2014-04-01 | 2016-11-03 |
| Colchicine For Prevention of Perioperative Atrial Fibrillation in Patients Undergoing Thoracic Surgery Pilot Study Colchicine 0.6 mg, Placebo Colchicine - Atrial Fibrillation, Thoracic Surgery | Phase 3 | Completed | Population Health Research Institute | 100 | 2014-04-01 | 2021-11-05 |
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COVID-19 (7) · Atrial Fibrillation (4) · Recurrence (4) · Pericarditis (3) · Acute Coronary Syndrome (2) · Arrhythmias, Cardiac (2) · Gout (2) · Inflammation (2) · ST Elevation Myocardial Infarction (2) · Stroke (2) · Aortic Valve Stenosis (1) · Atherosclerosis (1) · Coronary Artery Disease (1) · Coronavirus Infections (1) · Cytokine Release Syndrome (1)
Population Health Research Institute (5) · Azienda Sanitaria Locale 3, Torino (3) · Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia (2) · Takeda (2) · Ain Shams University (1) · Ayub Teaching Hospital (1) · Beijing Tiantan Hospital (1) · Estudios Clínicos Latino América (1) · Hamilton Health Sciences Corporation (1) · Insel Gruppe AG, University Hospital Bern (1) · Instituto de Investigación Marqués de Valdecilla (1) · Jordan Collaborating Cardiology Group (1) · Montreal Heart Institute (1) · National Center for Research Resources (NCRR) (1) · Ottawa Heart Institute Research Corporation (1)
Canada (9) · Spain (5) · United States (4) · Egypt (3) · Italy (3) · Switzerland (3) · Brazil (2) · Colombia (2) · Czechia (2) · Nepal (2) · Netherlands (2) · Pakistan (2) · United Kingdom (2) · Argentina (1) · Australia (1)
Alexander Benz, MD (1) · Alexandra Lansky, MD (1) · Andreas Orfanos, MD (1) · Domingo A Pascual Figal, MD (1) · Domingo Pascual Figal, MD (1) · Eduardo Ramacciotti, MD, PhD (1) · Emilie Belley-Cote, MD PhD (1) · Esper Kallas, MD, PhD (1) · Fernando Rodrigues, MD, PhD (1) · Jean-Claude Tardif, MD (1) · John Eikelboom, FRACP FRCPA (1)
PMID 34269908, PMID 34658014, PMID 38505729, PMID 15308692, PMID 15320751, PMID 16134130, PMID 20131255, PMID 20336760, PMID 20805112, PMID 21435708, PMID 21873705, PMID 21884871, PMID 22090167, PMID 23208422, PMID 23992557, PMID 24773578, PMID 25925674, PMID 26576054, PMID 27344959, PMID 27502857, PMID 27585965, PMID 29426008, PMID 30073793, PMID 30349811, PMID 30976418, PMID 31733140, PMID 31978293, PMID 32020029, PMID 32074550, PMID 32083985, PMID 32109013, PMID 32150618, PMID 32171740, PMID 32187464, PMID 32192578, PMID 32205204, PMID 32648087, PMID 32860034, PMID 34461322, PMID 34488841, PMID 34539185, PMID 34957385, PMID 34964849, PMID 36228639, PMID 36228641, PMID 36526898, PMID 36828654, PMID 37060288, PMID 37489818, PMID 38126206
2015 (1)