17 completed, 1 active not recruiting. 13 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 12, Active not recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 1 | Completed 1 |
Follow Cocoa: new trials by email Literature Review of Cocoa trials Research Report on Cocoa
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of a Food Supplement with Natural Extracts of Cocoa, Amaranth Seed and Ginger in Overweight or Obese Patients Cocoa, amaranth seed and ginger, Amaranth seed, Cocoa - Oxidative Stress, Inflammation Biomarkers | Not applicable | Active not recruiting | University of Guadalajara | 40 | 2023-08-20 | 2025-01-10 |
| Effect of Cocoa Supplementation Peripheral and Autonomic Diabetic Neuropathy Cocoa, Placebo - Diabetic Neuropathies | Not applicable | Completed | Anahuac University | 39 | 2021-06-04 | 2025-05-01 |
| The Effect of Cocoa on Platelet Function Profiles in Patients Cocoa - Platelet Dysfunction | Not applicable | Completed | The University of The West Indies | 25 | 2020-09-01 | 2023-08-25 |
| Effect of Cocoa Supplementation in Training Athletes Microbiota and Metabolome cocoa, Placebo - Healthy Athletes | Not applicable | Completed | Universidad Europea de Madrid | 40 | 2020-07-01 | 2020-11-04 |
| Can a Flavonoid-rich Pure Cocoa Reduce Fatigue in People With Parkinson's (PD) Cocoa - Parkinson Disease, Fatigue | Not applicable | Completed | Oxford Brookes University | 30 | 2017-07-01 | 2019-09-06 |
| Cocoa to Improve Walking Performance in Peripheral Artery Disease Cocoa, Placebo - Peripheral Artery Disease | Not applicable | Completed | Northwestern University | 44 | 2017-01-01 | 2020-08-06 |
| Effects of Hazelnuts and Cocoa on Metabolic Parameters and Vascular Reactivity Hazelnut, Cocoa, No hazelnuts / No cocoa - Cardiovascular Diseases, Glucose Metabolism Disorders | Not applicable | Completed | Ospedale San Donato | 61 | 2014-06-01 | 2016-09-09 |
| Cocoa and Metabolic Health in Prediabetes Cocoa, Placebo - Prediabetes | Not applicable | Completed | Virginia Polytechnic Institute and State University | 16 | 2014-06-01 | 2023-09-21 |
| Effect of Phytochemicals From Theobroma Cacao on Mental Energy Caffeinated cocoa, Cocoa, Caffeine - Mental Fatigue | Not applicable | Completed | University of Georgia | 24 | 2012-07-01 | 2018-06-25 |
| Chocolate's Effect on the Cerebral Vasculature cocoa - Cerebral Vasculature | Completed | NHS Greater Glasgow and Clyde | 24 | 2012-02-01 | 2012-07-27 | |
| Effects of Combining Cocoa and Soy in Type 2 Diabetes Soy protein, Isoflavones, Cocoa - Type 2 Diabetes, Dietary Intervention | Not applicable | Completed | Hull University Teaching Hospitals NHS Trust | 84 | 2011-10-01 | 2019-07-15 |
| Cocoa Flavanols in Renal Disease Cocoa - End Stage Renal Disease, Endothelial Dysfunction | Phase 1 / Phase 2 | Completed | Klinik für Kardiologie, Pneumologie und Angiologie | 22 | 2011-08-01 | 2013-11-13 |
| Effects of Acute Ingestion of Dark Chocolate on Endothelial Function in Hypertensive Patients Dark chocolate - Hypertension | Phase 4 | Completed | Hospital Universitario Pedro Ernesto | 21 | 2011-01-01 | 2012-01-11 |
| The Effect of Theobromine on Blood Lipid Parameters in Healthy Subjects Theobromine, Cocoa, Cocoa and theobromine - Cardiovascular Diseases | Not applicable | Completed | Unilever R&D | 152 | 2010-12-01 | 2012-09-18 |
| Cocoa Flavanols and Exercise Capacity Cocoa - Exercise Capacity | Not applicable | Completed | Heinrich-Heine University, Duesseldorf | 13 | 2010-11-01 | 2013-11-08 |
| Cocoa Flavanols and Painfree Walking Distance cocoa - Peripheral Artery Disease, Diabetes Mellitus | Phase 1 / Phase 2 | Completed | Heinrich-Heine University, Duesseldorf | 62 | 2009-10-01 | 2013-11-13 |
| Flavanol-Rich Cocoa and Cerebral Blood Flow cocoa - Hypertension, Diabetes | Not applicable | Completed | Brigham and Women's Hospital | 60 | 2009-01-01 | 2014-04-30 |
| Cocoa, Polyphenols, and the Kidney in Healthy Subjects and in Subjects With Hypertension and Diabetes Mellitus Cocoa - Diabetes | Completed | Brigham and Women's Hospital | 228 | 2008-01-01 | 2015-03-31 |
Diabetes Mellitus (3) · Cardiovascular Diseases (2) · Diabetes Mellitus, Type 2 (2) · Fatigue (2) · Hypertension (2) · Obesity (2) · Peripheral Arterial Disease (2) · Diabetic Neuropathies (1) · Glucose Intolerance (1) · Glucose Metabolism Disorders (1) · Inflammation (1) · Insulin Resistance (1) · Kidney Failure, Chronic (1) · Mental Fatigue (1) · Overweight (1)
Brigham and Women's Hospital (2) · Heinrich-Heine University, Duesseldorf (2) · Anahuac University (1) · Hospital Universitario Pedro Ernesto (1) · Hull University Teaching Hospitals NHS Trust (1) · Klinik für Kardiologie, Pneumologie und Angiologie (1) · NHS Greater Glasgow and Clyde (1) · Northwestern University (1) · Ospedale San Donato (1) · Oxford Brookes University (1) · The University of The West Indies (1) · Unilever R&D (1) · Universidad Europea de Madrid (1) · University of Georgia (1) · University of Guadalajara (1)
United States (5) · Germany (3) · Italy (2) · Mexico (2) · United Kingdom (2) · Brazil (1) · France (1) · Spain (1) · Trinidad and Tobago (1)
Alex Reed (1) · Andrew P Neilson, PhD (1) · Christian Heiss, MD (1) · Ebrahim Barkouadh, M.D., M.P.H. (1) · Malte Kelm, MD (1) · Malte Kelm, MD, PhD (1) · Mar Larrosa, PhD (1) · Mary McDermott, MD (1) · Naomi D. Fisher, MD (1) · Nicole Neufingerl, MSc (1) · Norman K Hollenberg, M.D., Ph.D. (1) · Patrick O'Connor, PhD (1)
PMID 15276091, PMID 17386093, PMID 20539845, PMID 21778615, PMID 23595874, PMID 24643960, PMID 26485680, PMID 32078436, PMID 35331536, PMID 36100318, PMID 37916745
R01HL089570 (1), R21AG050897 (1)