17 completed, 2 unknown, 1 terminated, 1 withdrawn. 21 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 21 | Completed 17, Unknown 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 3 |
Follow Cocaine: new trials by email Literature Review of Cocaine trials Research Report on Cocaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase1, STP7 Cocaine Drug-Drug Interaction Study STP7 (mavoglurant), Placebo, Cocaine Hydrochloride - Cocaine Use Disorder | Phase 1 | Completed | Stalicla SA | 21 | 2024-04-15 | 2026-04-23 |
| Intranasal Cocaine and Temperature Regulation During Exercise Cocaine, Lidocaine - Hyperthermia, Cocaine Use | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 27 | 2023-09-01 | 2025-07-14 |
| Investigation of Cocaine Addiction Using mGluR5 PET and fMRI Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography - Cocaine Dependence | Phase 1 | Completed | Yale University | 32 | 2018-02-26 | 2024-02-29 |
| A Study of Metyrapone and Oxazepam Combination Product (EMB-001) and Cocaine EMB-001, Placebo, Cocaine IV - Cocaine Use Disorder | Phase 1 | Completed | Embera NeuroTherapeutics, Inc. | 18 | 2016-07-01 | 2017-08-01 |
| Complementary Combination Therapy for Cocaine Dependence Doxazosin, Modafinil, cocaine - Cocaine Dependence | Phase 1 | Completed | Baylor College of Medicine | 45 | 2015-08-01 | 2022-04-26 |
| Reinforcing Effects of Cocaine During Phendimetrazine Maintenance Phendimetrazine, Cocaine, Placebo - Cocaine Use Disorder | Phase 1 | Completed | William Stoops | 30 | 2015-08-01 | 2019-07-02 |
| GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration cocaine hydrochloride, exenatide, placebo - Cocaine Dependence | Phase 1 | Completed | Yale University | 13 | 2014-11-01 | 2023-02-16 |
| Topiramate-Phentermine Combinations for Cocaine Dependence Cocaine, Placebo, Phentermine - Cocaine Use Disorder | Phase 1 | Completed | University of Kentucky | 38 | 2014-09-01 | 2019-11-27 |
| Validation of a Remote Wireless Sensor Network (WSN) Approach to the Individualized Detection of Cocaine Use in Humans Cocaine hydrochloride, Exercise, Nicotine - Cocaine Dependence | Phase 1 | Completed | Yale University | 5 | 2013-10-01 | 2023-02-16 |
| Impulsivity and Stimulant Administration cocaine hydrochloride, methylphenidate - Cocaine Dependence, Impulsivity | Phase 1 | Completed | Yale University | 29 | 2012-11-01 | 2023-02-16 |
| Interactions Between Intravenous Cocaine and Acetazolamide or Quinine cocaine, quinine, acetazolamide - Cocaine Use, Pharmacokinetics | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 14 | 2012-10-24 | 2018-07-05 |
| Establishing and Eliminating Cue-drug Associations in Human Cocaine Addiction cocaine hydrochloride, propranolol, placebo - Cocaine Dependent Subjects | Phase 1 | Terminated | Yale University | 6 | 2012-10-01 | 2020-03-02 |
| Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse Zonisamide, Placebo, Cocaine Hydrochloride - Cocaine Dependence | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 19 | 2010-06-01 | 2017-09-05 |
| Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers SYN117 Placebo, SYN117 80 mg, SYN117 160 mg - Cocaine Dependence | Phase 1 / Phase 2 | Completed | Biotie Therapies Inc. | 20 | 2008-06-01 | 2018-08-17 |
| Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1 Cocaine (IV) - Cocaine-Related Disorders | Phase 1 | Unknown | National Institute on Drug Abuse (NIDA) | 16 | 2004-09-01 | 2017-01-11 |
| Development of Human Laboratory Study Model of Cocaine Relapse Prevention. - 1 Cocaine (IV) - Cocaine-Related Disorders | Phase 1 | Unknown | National Institute on Drug Abuse (NIDA) | 32 | 2002-05-01 | 2017-01-11 |
| Stress Hormones and Human Cocaine Use - 7 Cocaine - Cocaine-Related Disorders | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 1997-05-01 | 2017-01-12 | |
| Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1 Cocaine - Cocaine-Related Disorders | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 1996-11-01 | 2017-01-12 | |
| Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2 Cocaine - Cocaine-Related Disorders | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 1996-08-01 | 2017-01-12 | |
| Acute Withdrawal From Smoked Cocaine - 9 Cocaine - Cocaine-Related Disorders, Substance Withdrawal Syndrome | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 1996-04-01 | 2017-01-12 |
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Cocaine-Related Disorders (13) · Substance-Related Disorders (2) · Behavior, Addictive (1) · Hyperthermia (1) · Impulsive Behavior (1) · Motor Activity (1) · Substance Withdrawal Syndrome (1)
National Institute on Drug Abuse (NIDA) (7) · Yale University (5) · University of Texas Southwestern Medical Center (2) · Baylor College of Medicine (1) · Biotie Therapies Inc. (1) · Embera NeuroTherapeutics, Inc. (1) · Johns Hopkins University (1) · Stalicla SA (1) · University of Kentucky (1) · William Stoops (1)
United States (21)
Dean Wong, M.D., Ph.D. (2) · Debra Kelsh, MD (2) · Dorothy Hatsukami, Ph.D. (2) · John Roache, Ph.D. (2) · Annie Umbricht, M.D. (1) · Craig R Rush, Ph.D. (1) · F. Gerald Moeller, MD (1) · Gustavo Angarita, M.D. (1) · Kathryn Cunningham, PhD (1) · Marilyn Huestis, Ph.D. (1) · Patrick Worhunsky, PhD (1) · Ronald G Victor, MD (1) · Stephen Bandak, MD (1)
PMID 38551365, PMID 10430763, PMID 17692748, PMID 23283356, PMID 28881319, PMID 41249021
K01DA042998 (1), R01DA027065 (1), R01DA032254 (1), R01DA036553 (1), R21DA040914 (1), R25MH071584 (1), U01DA038879 (1)