16 completed, 4 recruiting, 3 unknown, 3 withdrawn. 10 Not applicable, 9 Phase 3, 7 Phase 2, 5 Phase 4, 1 Early Phase 1.
Follow Citicoline: new trials by email Literature Review of Citicoline trials Research Report on Citicoline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Citicoline on Neurological Severity Score and Cerebral Doppler Resistive Index in Neonatal Hypoxic Ischemic Encephalopathy Citicoline, Standard medical treatment - Hypoxic Ischaemic Encephalopathy (HIE) | Not applicable | Not yet recruiting | Khyber Girls Medical College | 86 | 2026-09-01 | 2026-08-24 |
| CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium Citicoline - Cognitive Decline, Delirium | Phase 2 | Recruiting | University of Milano Bicocca | 122 | 2026-06-03 | 2026-09-09 |
| Evaluate the Effects of Citicoline on Mood in Healthy Adults Citicoline, Placebo - Healthy | Not applicable | Recruiting | Kirin Holdings Company, Limited | 90 | 2025-07-31 | 2025-09-02 |
| Supplemental Citicoline Administration to Reduce Lung Injury Efficacy Trial (SCARLET) Citicoline, Saline/Placebo - COVID-19 | Phase 1 / Phase 2 | Active not recruiting | Ohio State University | 80 | 2023-06-06 | 2025-04-02 |
| Multimodal Morpho-functional Study in Glaucoma Patients-Citicoline Oral Solution Citicoline, Placebo - Primary Open Angle Glaucoma | Not applicable | Active not recruiting | Fondazione G.B. Bietti, IRCCS | 29 | 2022-01-25 | 2025-02-26 |
| Citicoline and Filtration Surgery Citicoline, Placebo - Glaucoma Therapy | Not applicable | Completed | Fondazione IRCCS Policlinico San Matteo di Pavia | 6 | 2021-08-10 | 2026-05-05 |
| The Impact of Air Travel on Passenger Cognitive Functions Citicoline, Cytochrome C6, Sodium Chloride Oral Product - Air Travel | Phase 2 / Phase 3 | Unknown | Dinara Zhumanbayeva | 50 | 2021-06-01 | 2021-03-17 |
| Citicoline as Neuroprotector in Preterm Citicoline, Placebo oral tablet - Pre-Term | Phase 3 | Recruiting | Sherief Abd-Elsalam | 40 | 2019-05-01 | 2019-05-29 |
| Citicoline as Neuroprotector in Neonates Exposed to Hypoxia Citicoline, Placebo - Neonatal Hypoxia | Phase 3 | Recruiting | Sherief Abd-Elsalam | 40 | 2019-02-01 | 2019-05-29 |
| Citicoline Concentration in Human Vitreous Citicoline - Neurodegenerative Diseases | Not applicable | Completed | Istituto di Ricerca Neuroftalmologia S.r.l. | 26 | 2018-03-21 | 2019-07-01 |
| Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy citicoline - Hypoxic-Ischemic Encephalopathy | Phase 3 | Unknown | Armed Forces Hospital, Pakistan | 50 | 2017-06-15 | 2017-06-09 |
| Citicoline in Non-Arteritic Ischemic Optic Neuropathy Citicoline - Non-arteritic Ischemic Optic Neuropathy | Not applicable | Completed | Fondazione G.B. Bietti, IRCCS | 40 | 2017-02-20 | 2023-11-24 |
| Ramelteon and Citicoline for Delirium Ramelteon, Citicoline - Delirium | Phase 4 | Withdrawn | University of Texas Southwestern Medical Center | 2016-07-01 | 2017-11-09 | |
| Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders Placebo, Citicoline, Pregnenolone - Alcohol Use Disorder, Bipolar Disorder | Phase 4 | Completed | Sherwood Brown, MD, PhD | 96 | 2016-05-01 | 2024-10-09 |
| Evaluation of the Effect of Citicoline and Docosahexaenoic Acid (DHA) on the Visual Function of Patients With Glaucoma Citicoline, Docosahexaenoic Acid (DHA), Citicoline and Docosahexaenoic Acid (DHA) - Glaucoma | Not applicable | Completed | Institut Catala de Retina | 73 | 2015-03-12 | 2022-09-02 |
| Citicoline for Alcohol Dependence Placebo, Citicoline - Alcohol Dependence | Phase 4 | Completed | University of Texas Southwestern Medical Center | 62 | 2014-04-01 | 2018-07-24 |
| Effects of CDP-Choline on Gating and Cognitive Deficits in First Episode Schizophrenia CDP-Choline, Cellulose - First Episode Schizophrenia | Phase 2 | Unknown | University of Ottawa | 40 | 2014-04-01 | 2014-03-17 |
| Citicoline and Omega-3 Fatty Acid Effects in Veterans With Traumatic Brain Injury (TBI) Citicoline, Omega-3, Rice bran oil - Traumatic Brain Injury, Substance Abuse | Not applicable | Withdrawn | Deborah Yurgelun-Todd | 2013-11-01 | 2015-01-19 | |
| Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy CITICOLINE, PLACEBO - Uveal Melanoma | Not applicable | Completed | Centre Hospitalier Universitaire de Nice | 21 | 2012-06-25 | 2025-02-24 |
| Cognizin Citicoline Dosing in a Healthy Adolescent Male Population Citicoline, Microcrystalline Cellulose - Neurocognitive Improvement | Early Phase 1 | Completed | Deborah Yurgelun-Todd | 84 | 2012-06-01 | 2019-02-18 |
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Brain Injuries, Traumatic (4) · Bipolar Disorder (3) · Glaucoma (3) · Alcoholism (2) · Cocaine-Related Disorders (2) · Delirium (2) · Hypoxia-Ischemia, Brain (2) · Ischemic Stroke (2) · Stroke (2) · Substance-Related Disorders (2) · Amphetamine-Related Disorders (1) · Asphyxia Neonatorum (1) · Brain Injuries (1) · COVID-19 (1) · Cerebral Infarction (1)
University of Texas Southwestern Medical Center (5) · Fondazione G.B. Bietti, IRCCS (3) · Deborah Yurgelun-Todd (2) · Mclean Hospital (2) · Sherief Abd-Elsalam (2) · Armed Forces Hospital, Pakistan (1) · Centre Hospitalier Universitaire de Nice (1) · Clinical Institute of the Brain, Russia (1) · Dinara Zhumanbayeva (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Ferrer Internacional S.A. (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Institut Catala de Retina (1) · Istituto di Ricerca Neuroftalmologia S.r.l. (1) · Khyber Girls Medical College (1)
United States (14) · Italy (6) · Egypt (2) · Pakistan (2) · Spain (2) · Canada (1) · France (1) · Germany (1) · Portugal (1) · Russia (1)
Sherwood Brown, M.D., Ph.D. (2) · Abeer Salamah, Lecturer (1) · Abeer Salamah, MD (1) · Alfonso Anton, MD, PhD (1) · Beth Ansel, PhD (1) · E. Sherwood Brown, MD, PhD (1) · E. Sherwood Brown, PH.D., M.D. (1) · Francesco Oddone, MD, PHD (1) · Giuseppe Bellelli, Medical doctor, full professor (1) · Howard Eisenberg, MD (1) · Jack Jallo, MD, PhD (1) · John Ward, MD (1) · Joseph Ricker, PhD (1) · May R Elsheikh, Lecturer (1)
PMID 16249960, PMID 31348806, PMID 10366081, PMID 11006239, PMID 11165541, PMID 11235540, PMID 12640353, PMID 15555526, PMID 16406535, PMID 18557920, PMID 18929133, PMID 21397626, PMID 22691567, PMID 23168823, PMID 24881599, PMID 25998279, PMID 26004075, PMID 26891880, PMID 28676014, PMID 29570721, PMID 29879191, PMID 30291364, PMID 31872278, PMID 32079996, PMID 33804675, PMID 37173784, PMID 38760804, PMID 42765966, PMID 7905600
2025 (1), K23HD049626 (1), R01DA019238 (1), R01DA022460 (1), R01DA024007 (1)