6 completed, 2 recruiting, 1 terminated, 1 unknown. 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 6, Recruiting 2, Terminated 1, Unknown 1 |
Follow Chlorthalidone: new trials by email Literature Review of Chlorthalidone trials Research Report on Chlorthalidone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Placebo - Hypertension | Phase 2 | Recruiting | Massachusetts General Hospital | 90 | 2026-03-20 | 2026-10-20 |
| Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention Indapamide 2.5 MG, Hydrochlorothiazide 50Mg, Chlorthalidone 25mg - Kidney Stone | Phase 2 | Recruiting | Insel Gruppe AG, University Hospital Bern | 99 | 2024-10-01 | 2026-05-06 |
| Spironolactone in CKD Enabled by Chlorthalidone: PILOT Spironolactone, Chlorthalidone, Placebo - Renal Insufficiency, Chronic Hypertension | Phase 2 | Unknown | Indiana Institute for Medical Research | 24 | 2022-02-01 | 2023-08-14 |
| Safety and Efficacy of Chlorthalidone in Type 1 Diabetes Chlorthalidone - Type 1 Diabetes Mellitus, Hypercalciuria | Phase 2 | Terminated | University of Rochester | 1 | 2019-06-28 | 2021-01-05 |
| Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial Chlorthalidone, Bumetanide - Renal Insufficiency, Chronic | Phase 2 | Completed | Hospital General de México Dr. Eduardo Liceaga | 34 | 2019-06-18 | 2020-11-23 |
| The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide. Furosemide intravenous solution, Chlortalidone, Spironolactone - Cardiorenal Syndrome | Phase 2 | Completed | Hospital Civil de Guadalajara | 80 | 2017-07-01 | 2020-09-14 |
| Chlorthalidone in Chronic Kidney Disease Chlorthalidone, Placebo - Renal Insufficiency, Chronic, Hypertension | Phase 2 | Completed | Indiana University | 160 | 2016-07-01 | 2023-05-15 |
| Tissue Sodium in Pre-hypertensive Patients Spironolactone, Chlorthalidone, Diet - Hypertension | Phase 2 | Completed | Vanderbilt University | 71 | 2014-09-01 | 2019-05-22 |
| Treatment of Mild Hypertension Study (TOMHS) diet, sodium-restricted, diet, reducing, exercise - Cardiovascular Diseases, Heart Diseases | Phase 2 | Completed | University of Minnesota | 1985-08-01 | 2016-02-25 | |
| Systolic Hypertension in the Elderly Program (SHEP) (Pilot Study) chlorthalidone, reserpine, hydralazine - Cardiovascular Diseases, Heart Diseases | Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1980-09-01 | 2013-11-26 |
Hypertension (6) · Renal Insufficiency, Chronic (3) · Cardiovascular Diseases (2) · Heart Diseases (2) · Vascular Diseases (2) · Cardio-Renal Syndrome (1) · Diabetes Mellitus, Type 1 (1) · Edema (1) · Hypercalciuria (1) · Hypertension, Pregnancy-Induced (1) · Kidney Calculi (1) · Nephrolithiasis (1) · Pre-Eclampsia (1) · Renal Insufficiency (1)
Hospital Civil de Guadalajara (1) · Hospital General de México Dr. Eduardo Liceaga (1) · Indiana Institute for Medical Research (1) · Indiana University (1) · Insel Gruppe AG, University Hospital Bern (1) · Massachusetts General Hospital (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · University of Minnesota (1) · University of Rochester (1) · Vanderbilt University (1)
United States (5) · Mexico (2) · Switzerland (1)
Rajiv Agarwal, MD (2) · Alp Ikizler, MD (1) · Daniel G Fuster, M.D. (1) · Fabio Solis-Jimenez, M.D. (1) · H. Perry (1) · Harold Schnaper (1) · James Schoenberger (1) · Jens Titze, MD (1) · Merwyn Greenlick (1) · Michael Honigberg, MD (1) · Richard Grimm (1) · Robert McDonald (1)
PMID 32663820, PMID 34739197, PMID 34979962, PMID 35435017, PMID 36127661, PMID 37156670, PMID 38865199
K23DK114477 (1), R01HL034767 (1), R01HL181150 (1)