6 completed, 6 unknown, 3 recruiting, 2 terminated. 17 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 6, Unknown 6, Recruiting 3, Terminated 2 |
| Phase 1 | 3 | Unknown 2, Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Cefazolin: new trials by email Literature Review of Cefazolin trials Research Report on Cefazolin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge - Drug Allergy, Cephalosporin Allergy | Phase 2 | Recruiting | Massachusetts General Hospital | 300 | 2025-05-05 | 2026-09-04 |
| Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term 2.0 Azithromycin, Placebo - Obesity in Pregnancy, Labor Complication | Phase 2 | Recruiting | University of Oklahoma | 787 | 2025-04-29 | 2026-03-12 |
| Antibiotic Tumescent For Chronic Wounds CeFAZolin Injectable Solution - Non-healing Wound | Phase 2 | Recruiting | University of California, Los Angeles | 60 | 2024-05-17 | 2026-04-23 |
| Prophylactic Antibiotics Duration Towards Healing and Risk of Infection in Permanent Pacemaker (PPM) Installation Cefazolin 1000 MG Injection - Pacemaker Complication | Phase 2 | Unknown | University of Brawijaya | 100 | 2023-09-01 | 2024-04-09 |
| Safety and Efficacy of Topical Moxifloxacin for Prevention of Post-Traumatic Endophthalmitis: Randomized Controlled Clinical Trial Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ciprofloxacin 400 MG/200 ML Intravenous Solution [CIPRO IV] - Endophthalmitis, Open Globe Injury | Phase 2 | Unknown | University of Campinas, Brazil | 100 | 2021-12-10 | 2021-12-17 |
| DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia Cefazolin, Dalbavancin, Daptomycin - Staphylococcal Bacteraemia | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 200 | 2021-04-22 | 2024-12-10 |
| Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus Afabicin, Cefazolin, Vancomycin - Bone or Joint Infection | Phase 2 | Terminated | Debiopharm International SA | 67 | 2019-02-20 | 2026-09-09 |
| Phase 2 Randomized Study to Compare Ultrasonic Drug Delivery to Standard of Care for the Treatment of Infections in Non-Healing Wounds Ultrasonic Drug Delivery, Standard of Care Antibiotic Treatment - Acute Bacterial Skin and Skin Structure Infection (ABSSSI), Non-healing Wound | Phase 2 | Unknown | Sonescence, Inc. | 30 | 2019-02-01 | 2018-11-06 |
| Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions Cefazolin - Premalignant Vulvar Lesion, Benign Vulvar Lesion | Phase 2 | Completed | Washington University School of Medicine | 50 | 2018-07-13 | 2022-11-21 |
| Addition of Azithromycin to Cefazolin Will Reduce Post CS Infections More Than Cefazolin Only. Azithromycin - Randomized Controll Trial | Phase 1 / Phase 2 | Unknown | Ain Shams University | 400 | 2018-04-20 | 2018-04-18 |
| The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy Vancomycin, Cefazolin - Elective Craniotomy-candidated Patients | Phase 1 / Phase 2 | Unknown | Isfahan University of Medical Sciences | 126 | 2018-04-01 | 2018-03-15 |
| The Effect of Bowel Preparation on Perioperative Bleeding PEG, placebo, Cefazolin - Surgery | Phase 1 / Phase 2 | Completed | Isfahan University of Medical Sciences | 105 | 2014-07-01 | 2015-07-10 |
| Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection CEM-102, IV or Oral standard of care antibiotics, Rifampin - Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee | Phase 2 | Terminated | Arrevus Inc. | 14 | 2012-12-01 | 2019-04-19 |
| Efficacy Assessment of Two Antibiotic Prophylaxis Regimens in Oral and Maxillofacial Trauma Surgery Cefazolin, Cefazolin Single Dose - Facial Fractures | Phase 2 | Unknown | Universidade Federal do Rio Grande do Norte | 75 | 2011-12-01 | 2013-11-25 |
| Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection Vancomycin - Bacteremia | Phase 2 | Completed | Duke University | 509 | 2011-02-01 | 2018-01-05 |
| Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis IV cefazolin plus oral probenecid and placebo cephalexin, Oral cephalexin and saline IV plus probenecid placebo - Cellulitis | Phase 2 | Completed | Kelowna General Hospital | 206 | 2010-05-01 | 2018-08-13 |
| Role of Antibiotics to Reduce Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax Ancef or Clindamycin, Placebo - Hemopneumothorax, Pneumothorax | Phase 2 / Phase 3 | Completed | St. Luke's Hospital, Pennsylvania | 50 | 2005-07-01 | 2010-05-21 |
Bacteremia (2) · Anaphylaxis (1) · Cellulitis (1) · Drug Hypersensitivity (1) · Emergencies (1) · Endophthalmitis (1) · Hemopneumothorax (1) · Hypersensitivity (1) · Infections (1) · Obstetric Labor Complications (1) · Pneumothorax (1) · Pregnancy in Obesity (1) · Staphylococcal Infections (1)
Isfahan University of Medical Sciences (2) · Ain Shams University (1) · Arrevus Inc. (1) · Debiopharm International SA (1) · Duke University (1) · Kelowna General Hospital (1) · Massachusetts General Hospital (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Sonescence, Inc. (1) · St. Luke's Hospital, Pennsylvania (1) · Universidade Federal do Rio Grande do Norte (1) · University of Brawijaya (1) · University of California, Los Angeles (1) · University of Campinas, Brazil (1) · University of Oklahoma (1)
United States (8) · Brazil (2) · Canada (2) · Iran (2) · Egypt (1) · Georgia (1) · Indonesia (1) · South Africa (1) · Spain (1) · Ukraine (1)
Adriano Germano, PhD (1) · David A Khan, MD (1) · David G Armstrong, Ph.D., DPM (1) · Dawn Dalen, PharmD (1) · Icmi D Rochmawati, M.D. (1) · Kimberly G Blumenthal, MD, MSc (1) · Mary M Mullen, M.D. (1) · Nathaniel McQuay, MD (1) · Peter Zed, PharmD (1) · Reza Abbasi, MD (1) · Seth Putterman, PhD (1) · Stephanie Pierce, MD (1) · Vance Fowler, MD (1)
PMID 25532706, PMID 27682068, PMID 29914924, PMID 30264119, PMID 35578360, PMID 40802264, PMID 41999282
5UM1AI104681-12 (1), U01AI184071 (1)