12 completed, 2 active not recruiting, 2 recruiting, 2 unknown. 4 Phase 2, 4 Phase 3, 3 Phase 4, 2 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Recruiting 1 |
| Phase 3 | 4 | Active not recruiting 2, Completed 2 |
| Phase 4 | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Not applicable | 2 | Completed 2 |
| Phase 1 | 2 | Completed 2 |
Follow Bisphosphonate: new trials by email Literature Review of Bisphosphonate trials Research Report on Bisphosphonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases Zanzalintinib, Investigator Choice of Bone Strengthening Agents (BSA), Non-Investigational Radiation Therapy (RT) - Clear Cell Renal Cell Cancer (ccRCC), Clear Cell Renal Carcinoma | Phase 2 | Recruiting | Kelly Fitzgerald, MD | 20 | 2026-06-10 | 2026-07-27 |
| Effect of Local Subperiosteal Zoledronic Acid Injection on the Survival of Orthodontic Miniscrews Zoledronic Acid, Normal saline (0.9% sodium chloride) - Orthodontic Appliance Complication | Not applicable | Completed | Latakia University | 68 | 2024-12-01 | 2026-04-22 |
| Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta Romosozumab, Bisphosphonate - Osteogenesis Imperfecta | Phase 3 | Active not recruiting | Amgen | 111 | 2024-04-22 | 2026-05-27 |
| Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta Bisphosphonate, Setrusumab - Osteogenesis Imperfecta | Phase 3 | Active not recruiting | Ultragenyx Pharmaceutical Inc | 69 | 2023-06-14 | 2026-10-20 |
| Bone, Exercise, Alendronate, and Caloric Restriction Bisphosphonate, Resistance Training/Bone-Loading Exercise, Placebo - Bone Loss | Phase 4 | Recruiting | Wake Forest University Health Sciences | 900 | 2023-06-08 | 2026-06-09 |
| Prospective Research for Elderly (≥65 Years Old) Early Breast Cancer Patients operation, Bisphosphonate - Breast Cancer Female | Unknown | Peking Union Medical College Hospital | 1000 | 2022-04-01 | 2023-01-11 | |
| Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta? Risedronate Sodium, Calcichew tablets - Osteogenesis Imperfecta | Phase 2 | Completed | Sheffield Children's NHS Foundation Trust | 13 | 2017-04-01 | 2018-09-07 |
| Effectiveness or Orthopedic Intervention in Osteoporosis Management After a Fracture of the Hip With Cost-Benefit Analysis Letter Group, Intervention Group - Osteoporotic Fracture | Not applicable | Completed | Shaare Zedek Medical Center | 200 | 2017-02-21 | 2019-04-05 |
| Exome Sequencing for Atypical Femoral Fractures Bisphosphonate - Atypical Femoral Fractures, Osteoporosis | Completed | Washington University School of Medicine | 38 | 2016-04-01 | 2018-12-31 | |
| Breast Cancer Women on Aromatase Inhibitors Treatment bisphosphonate - Osteoporosis, Osteoporosis Fracture | Phase 4 | Unknown | Parc de Salut Mar | 1000 | 2016-01-01 | 2019-01-28 |
| Prevention of Bone Loss After Acute SCI by Zoledronic Acid Zoledronic acid, Placebo - Spinal Cord Injury, Acute Spinal Cord Injury | Phase 2 | Completed | Northwestern University | 60 | 2015-02-01 | 2025-12-02 |
| The Effect of Alendronate on the Immune Response to Hepatitis B Vaccine in Healthy Adults Alendronate, Hepatitis B Vaccine, Placebo - Hepatitis B | Phase 1 | Completed | Massachusetts General Hospital | 28 | 2014-04-01 | 2016-10-21 |
| Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU) Bazedoxifene, Bisphosphonate, Raloxifene - Osteoporosis, Postmenopausal | Completed | Pfizer | 10497 | 2011-07-25 | 2024-04-22 | |
| Denosumab Safety Assessment in Multiple Observational Databases denosumab, bisphosphonate - Osteoporosis | Completed | Amgen | 517991 | 2010-05-31 | 2024-11-04 | |
| Study in Localized and Disseminated Ewing Sarcoma Zoledronic acid, Busulfan, Treosulfan - Ewing's Sarcoma | Phase 3 | Completed | University Hospital Muenster | 907 | 2009-10-01 | 2019-10-22 |
| Queen's University Investigation of Calcification in Chronic Kidney Disease Bisphosphonate, Placebo - Chronic Kidney Disease | Phase 3 | Completed | Queen's University | 25 | 2008-10-01 | 2015-09-28 |
| The Change of Bone Markers After Low Dose Alendronate in Postmenopausal Women With Bone Loss Alendronate - Osteoporosis | Phase 4 | Completed | Eulji University Hospital | 63 | 2006-03-01 | 2014-08-05 |
| Randomized Trial of Risedronate to Prevent Bone Loss in Renal Transplant Recipients. Risedronate, Placebo - Renal Transplant Osteodystrophy | Phase 1 / Phase 2 | Completed | Montefiore Medical Center | 60 | 2002-10-01 | 2019-03-01 |
Osteoporosis (8) · Bone Diseases, Metabolic (3) · Osteogenesis Imperfecta (3) · Breast Neoplasms (2) · Neoplasm Metastasis (2) · Osteoporotic Fractures (2) · Arthralgia (1) · Bone Diseases (1) · Carcinoma, Renal Cell (1) · Central Nervous System Diseases (1) · Clear-cell metastatic renal cell carcinoma (1) · Fractures, Spontaneous (1) · Fractures, Stress (1) · Hepatitis B (1) · Kidney Failure, Chronic (1)
Amgen (2) · Eulji University Hospital (1) · Kelly Fitzgerald, MD (1) · Latakia University (1) · Massachusetts General Hospital (1) · Montefiore Medical Center (1) · Northwestern University (1) · Parc de Salut Mar (1) · Peking Union Medical College Hospital (1) · Pfizer (1) · Queen's University (1) · Shaare Zedek Medical Center (1) · Sheffield Children's NHS Foundation Trust (1) · Ultragenyx Pharmaceutical Inc (1) · University Hospital Muenster (1)
United States (7) · Canada (3) · China (2) · France (2) · Germany (2) · Italy (2) · Poland (2) · Spain (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Hungary (1) · Israel (1)
Alan W Craft, Prof Sir MD (1) · Gershon Zinger, MD MS (1) · Hee-Jeong Choi, MD, PhD (1) · Karen E Yeates, Dr (1) · Kelly Fitzgerald, MD (1) · Kristen Beavers, PhD (1) · Maria Coco, MD, MS (1) · Nick Bishop, MD, FRCPCH (1) · Shadi G Moawad, Ph.D (1) · Steven Mumm, PhD (1) · Thomas J Schnitzer, MD, PhD (1)
PMID 42470570, PMID 16637733, PMID 20152674, PMID 22797188, PMID 26271204, PMID 26327926, PMID 30334093, PMID 30477773, PMID 31127467, PMID 31553693, PMID 33409700, PMID 34180292, PMID 34278611, PMID 35427190, PMID 38524902, PMID 39796745
2023 (2), 2008 (1), R01AG074979 (1)