29 completed, 4 terminated, 3 unknown, 2 withdrawn. 16 Phase 3, 10 Phase 4, 7 Phase 2, 3 Phase 1, 2 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) Finerenone, Semaglutide, Lotensin - Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Enrolling by invitation | Baylor Research Institute | 64 | 2026-04-08 | 2026-10-13 |
| Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection? Losartan, Valsartan, Azilsartan - Covid19, SARS-CoV Infection | Phase 3 | Terminated | University of British Columbia | 341 | 2020-10-09 | 2023-02-16 |
| Candesartan as an Adjunctive Treatment for Bipolar Depression Candesartan, Placebo - Bipolar Disorder Depression | Early Phase 1 | Withdrawn | The University of Texas Health Science Center, Houston | 2020-10-01 | 2022-04-27 | |
| Candesartan's Effects on Alzheimer's Disease And Related Biomarkers Placebo, Candesartan - Mild Cognitive Impairment | Phase 2 | Completed | Emory University | 77 | 2016-06-30 | 2022-12-01 |
| Relative Bioavailability Study of Candesartan Cilexetil Under Fasting Conditions Candesartan Cilexetil in formulation 1, Candesartan Cilexetil in formulation 2, ATACAND - Cardiovascular Disease | Phase 1 | Completed | GlaxoSmithKline | 18 | 2014-12-02 | 2018-03-12 |
| CAndesartan vs LIsinopril Effects on the BRain Candesartan, Lisinopril - Hypertension, Mild Cognitive Impairment | Phase 2 | Completed | Emory University | 176 | 2014-08-20 | 2021-02-21 |
| Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression Sertraline, Candesartan - Depression, Hypertension | Phase 4 | Terminated | Vanderbilt University | 1 | 2013-05-01 | 2016-10-20 |
| A Pilot Study of Candesartan as a Treatment for Cocaine Dependence Candesartan with CBT, Placebo with CBT - Cocaine Dependence | Phase 2 | Terminated | Baylor College of Medicine | 30 | 2013-01-01 | 2019-09-04 |
| RAS Quantification in Patients With Aliskiren or Candesartan RAS blockade discontinuation, Aliskiren, Candesartan - Hypertension, Chronic Kidney Disease | Phase 4 | Completed | Medical University of Vienna | 24 | 2012-12-01 | 2016-03-16 |
| CR Aim #2 - AT1 Receptor Blockade & ACE Inhibition Effect on Humoral Function Candesartan, Placebo - Cardiorenal Syndrome (CRS) | Phase 1 / Phase 2 | Completed | Mayo Clinic | 33 | 2012-02-01 | 2021-11-18 |
| Efficacy and Safety of a Therapy Change From Candesartan 32 mg to Fixed Combination of Olmesartan 40 mg/Amlodipine 10 mg Candesartan cilexetil, Olmesartan medoxomil, Olmesartan/amlodipine - Hypertension | Phase 4 | Completed | Institut für Pharmakologie und Präventive Medizin | 88 | 2012-01-01 | 2017-02-23 |
| Cognitive Function and Electrocardiogram (ECG) During Hypoglycemia and Blockade of the Renin-angiotensin System Angiotensin II receptor antagonists (Candesartan), Placebo - Type 1 Diabetes, Hypoglycemia | Not applicable | Completed | Louise Faerch | 9 | 2010-04-01 | 2013-02-05 |
| The Potential of Candesartan to Retard the Progression of Aortic Stenosis candesartan, placebo - Aortic Valve Stenosis | Phase 3 | Unknown | University of Helsinki | 120 | 2009-05-01 | 2009-05-19 |
| An ACE Inhibitor (Perindopril) or an Angiotensin Receptor Blocker (Candesartan) as a Treatment for Methamphetamine Dependence Perindopril, Placebo, Candesartan - Methamphetamine Dependence, Methamphetamine Abuse | Phase 1 | Completed | Baylor College of Medicine | 80 | 2009-05-01 | 2022-04-26 |
| Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker Candesartan - Hypertension | Not applicable | Unknown | Slovak Academy of Sciences | 35 | 2008-10-01 | 2011-10-03 |
| Atacand (Candesartan) Real Life Study Candesartan Cilexetil, Losartan - Hypertension | Completed | AstraZeneca | 14000 | 2008-03-01 | 2010-12-02 | |
| Candesartan Effect in Second Stage Arterial Hypertension Candesartan Cilexetil, Hydrochlorothiazide - Stage II Hypertension | Phase 4 | Completed | AstraZeneca | 214 | 2008-02-01 | 2010-03-23 |
| Observational Usage and Efficacy Study of Candesartan in Heart Failure Treatment in France Candesartan - Heart Failure, Cohort Study | Completed | AstraZeneca | 450 | 2008-01-01 | 2010-12-02 | |
| The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial candesartan, lisinopril, hydrochlorothiazide - Cognitive Impairment, Hypertension | Phase 2 | Completed | University of Southern California | 53 | 2008-01-01 | 2013-02-15 |
| ARIA (Atacand Renoprotection In NephropAthy Pt.) Candesartan Cilexetil, Candesartan Cilexetil 32mg - Non-diabetic Nephropathy With Hypertension | Phase 4 | Completed | AstraZeneca | 128 | 2007-12-01 | 2011-08-23 |
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Hypertension (16) · Heart Failure (7) · Cognitive Dysfunction (3) · Diabetes Mellitus, Type 1 (3) · Cardiovascular Diseases (2) · Diabetes Mellitus, Type 2 (2) · Renal Insufficiency, Chronic (2) · Acute Kidney Injury (1) · Albuminuria (1) · Alzheimer Disease (1) · Aortic Valve Stenosis (1) · Bipolar Disorder (1) · COVID-19 (1) · Cardio-Renal Syndrome (1) · Cocaine-Related Disorders (1)
AstraZeneca (17) · Baylor College of Medicine (2) · Emory University (2) · Mayo Clinic (2) · Baylor Research Institute (1) · GlaxoSmithKline (1) · Institut für Pharmakologie und Präventive Medizin (1) · Kaiser Permanente (1) · Karin Skov (1) · Louise Faerch (1) · Medical University of Vienna (1) · Montreal Heart Institute (1) · Slovak Academy of Sciences (1) · Takeda (1) · The University of Texas Health Science Center, Houston (1)
United States (14) · Denmark (5) · France (5) · Germany (4) · Belgium (3) · Poland (3) · South Korea (3) · Sweden (3) · Ukraine (3) · Canada (2) · Italy (2) · Slovakia (2) · United Kingdom (2) · Australia (1) · Austria (1)
Ihab Hajjar, MD (2) · Birger Thorsteinsson, Prof DMSc MD (1) · Bjorn Eriksson, MD (1) · Chris Granger, MD (1) · Da Suk Han (1) · Dong Hoon Choi (1) · Dr Salim Yusuf (1) · Franz Schaefer, MD (1) · Gerd Bonner, MD (1) · Hans Persson, MD, PhD (1)
PMID 19196892, PMID 19451554, PMID 21225239, PMID 21309844, PMID 25326006, PMID 29431256, PMID 37366061, PMID 38682786, PMID 18823656, PMID 16537662, PMID 18823658, PMID 20160654, PMID 21602709, PMID 21831438, PMID 22093207, PMID 22412114, PMID 23350899, PMID 24874200, PMID 25469804, PMID 25627429, PMID 29701105, PMID 31370950, PMID 31982649, PMID 32761160, PMID 33301080, PMID 36440097, PMID 36632831, PMID 39325643, PMID 40864017
2005 (1), K23AG030057 (1), P50DA018197 (1), R01AG042127 (1), R01AG049752 (1), R01DA023468 (1), R01HL084155 (1)