26 terminated. 26 Phase 2, 3 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 26 | Terminated 26 |
| Phase 1 | 3 | Terminated 3 |
| Phase 3 | 3 | Terminated 3 |
Follow Ascorbic Acid: new trials by email Literature Review of Ascorbic Acid trials Research Report on Ascorbic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer Ascorbic acid, Normal Saline - Lung Cancer | Phase 2 | Terminated | The Canadian College of Naturopathic Medicine | 3 | 2024-10-01 | 2026-10-14 |
| Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock. Vitamin C (Laroscorbine) + Vitamin B1 (Bevitine), standard treatment - Cardiac Arrest | Phase 2 | Terminated | Centre Hospitalier de Bethune | 65 | 2023-12-27 | 2026-10-27 |
| Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer Olaparib, Vitamin C - Prostate Cancer, Castration-resistant Prostate Cancer | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 4 | 2023-06-30 | 2025-01-29 |
| Immunonutrition for Diabetic Foot Ulcers Lovaza, L-Arginine Powder, Vitamin C - Diabetes Mellitus, Diabetic Peripheral Neuropathy | Phase 2 / Phase 3 | Terminated | Prisma Health-Midlands | 1 | 2023-02-08 | 2024-12-27 |
| HAT for the Treatment of Sepsis Associated With NASTI HAT, Placebo - Necrotizing Soft Tissue Infection, Sepsis | Phase 1 / Phase 2 | Terminated | Ascension Health | 10 | 2021-09-10 | 2024-07-24 |
| Vitamin C as add-on Therapy in Patients With Acute Herpes Zoster Vitamin C - Neuropathic Pain | Phase 2 | Terminated | Pascoe Pharmazeutische Praeparate GmbH | 12 | 2020-07-20 | 2024-11-07 |
| Treatment for COVID-19 in High-Risk Adult Outpatients Ascorbic Acid, Hydroxychloroquine Sulfate, Azithromycin - COVID-19, SARS-CoV-2 | Phase 2 / Phase 3 | Terminated | University of Washington | 289 | 2020-04-16 | 2022-08-08 |
| Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia VC, Sterile Water for Injection - Vitamin C, Pneumonia, Viral | Phase 2 | Terminated | ZhiYong Peng | 56 | 2020-02-14 | 2020-10-12 |
| Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock Stress-dose Hydrocortisone plus Vitamin C, isotonic sodium chloride solution placebo plus isotonic sodium chloride solution placebo - Septic Shock | Phase 1 / Phase 2 | Terminated | University of Athens | 26 | 2018-09-06 | 2024-12-19 |
| Gemcitabine Plus Ascorbate for Sarcoma in Adults Ascorbate, Gemcitabine - Sarcoma, Soft Tissue Sarcoma | Phase 2 | Terminated | Mohammed Milhem, MBBS | 10 | 2018-07-11 | 2020-12-10 |
| Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock Triple therapy group - Septic Shock, Critical Illness | Phase 2 / Phase 3 | Terminated | Hamad Medical Corporation | 106 | 2018-03-17 | 2021-12-10 |
| Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery Ascorbic Acid, Pazopanib Hydrochloride - Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma | Phase 2 | Terminated | Academic and Community Cancer Research United | 5 | 2018-02-16 | 2022-03-31 |
| Docetaxel With or Without Ascorbic Acid in Treating Patients With Metastatic Prostate Cancer Ascorbic Acid, Docetaxel, Laboratory Biomarker Analysis - Hormone-Resistant Prostate Cancer, Metastatic Prostate Carcinoma | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 50 | 2016-06-20 | 2023-06-07 |
| Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease ISMN, Vitamin C - Renal Insufficiency, Chronic | Phase 2 | Terminated | University of Pennsylvania | 8 | 2016-05-01 | 2020-08-13 |
| High Dose Intravenous Ascorbic Acid in Severe Sepsis Ascorbic Acid, Normal Saline - Sepsis | Phase 2 | Terminated | Christiana Care Health Services | 24 | 2016-04-01 | 2021-02-16 |
| Interest of Ascorbic Acid in the Management of Pneumonia in Elderly People Hospitalized. Vitamin C, Placebo - Pneumonia With Hospitalized Elderly Patient | Phase 2 | Terminated | University Hospital, Bordeaux | 9 | 2015-02-01 | 2026-05-22 |
| Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma Vitamin C, Vitamin E, Saline (for Vitamin C) - Coagulopathy, Nosocomial Pneumonia | Phase 2 | Terminated | University of Alabama at Birmingham | 11 | 2013-05-01 | 2017-03-29 |
| High Dose Vitamin C in the Critically Ill Patient Ascorbic Acid, Ringers Lactate or Normal Saline - Shock | Phase 2 | Terminated | Rutgers, The State University of New Jersey | 11 | 2013-02-01 | 2017-05-11 |
| Clinical Trial of High-dose Vitamin C for Advanced Pancreatic Cancer Gemcitabine with escalating ascorbic acid - Pancreatic Neoplasms, Pancreatic Cancer | Phase 2 | Terminated | Joseph J. Cullen | 1 | 2012-09-01 | 2017-06-08 |
| Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA Ascorbic Acid, Irinotecan - Stage IV Colorectal Cancer | Phase 1 / Phase 2 | Terminated | Thomas Jefferson University | 4 | 2011-12-01 | 2025-05-06 |
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Digestive System Diseases (2) · Digestive System Neoplasms (2) · Neoplasms (2) · Neoplasms by Site (2) · Pancreatic Neoplasms (2) · Prostatic Neoplasms (2) · Sepsis (2) · Shock, Septic (2) · Atherosclerosis (1) · Bone Neoplasms (1) · COVID-19 (1) · Carcinoma, Renal Cell (1) · Cardiovascular Diseases (1) · Carotid Artery Diseases (1) · Cerebrovascular Disorders (1)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Thomas Jefferson University (2) · Academic and Community Cancer Research United (1) · Ascension Health (1) · Centre Hospitalier de Bethune (1) · Christiana Care Health Services (1) · Fondazione Italiana Sindromi Mielodisplastiche-ETS (1) · Hamad Medical Corporation (1) · Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes (1) · Joseph J. Cullen (1) · Mohammed Milhem, MBBS (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · OHSU Knight Cancer Institute (1) · Pascoe Pharmazeutische Praeparate GmbH (1) · Prisma Health-Midlands (1)
United States (17) · France (2) · Canada (1) · China (1) · Germany (1) · Greece (1) · Italy (1) · Mexico (1) · Qatar (1)
Channing Paller, MD (2) · Daniel A Monti, MD (2) · Adham Mohamed, PharmD (1) · Aleksandra Simic, MD (1) · Alessandro Levis, MD (1) · Anastasia Kotanidou, MD, PhD (1) · Andraes Pinter, Dr. (1) · Christine Johnston, MD, MPH (1) · Dan Douer, MD (1) · Edith P Mitchell, MD (1) · Felipe Vadillo-Ortega, M.D.,Ph.D. (1) · Holger Michels (1) · J. Benjamin Jackson, MD (1)
PMID 10722036, PMID 1138591, PMID 11502226, PMID 12454520, PMID 12545007, PMID 12700374, PMID 1607900, PMID 16570523, PMID 18353115, PMID 20332511, PMID 20646908, PMID 21596735, PMID 227054, PMID 22964015, PMID 23525934, PMID 24484547, PMID 24838355, PMID 26771781, PMID 26903338, PMID 27162802, PMID 27695824, PMID 27940189, PMID 28098591, PMID 32641343, PMID 33681731, PMID 34473343, PMID 35604806, PMID 36870070, PMID 39076107, PMID 3928249, PMID 39317492, PMID 8615361, PMID 8625625
2014 (1), P30CA006973 (1), P30CA015083 (1), P30CA069533 (1), P30CA086862 (1), U01HL052073 (1)