5 terminated, 3 completed, 2 recruiting, 1 suspended. 6 Phase 2, 5 Early Phase 1, 4 Phase 1.
Follow Angiotensin-(1-7): new trials by email Literature Review of Angiotensin-(1-7) trials Research Report on Angiotensin-(1-7)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension Angiotensin-(1-7), Saline - Obesity, Hypertension | Early Phase 1 | Recruiting | Milton S. Hershey Medical Center | 52 | 2025-01-23 | 2026-09-24 |
| TXA127 in Non-Ambulant Patients With DMD Cardiomyopathy talfirastide - DMD-Associated Dilated Cardiomyopathy | Phase 2 | Unknown | Constant Therapeutics LLC | 10 | 2023-08-31 | 2024-01-23 |
| Angiotensin-(1-7) Cardiovascular Effects in Aging Angiotensin-(1-7), Saline - Aging | Early Phase 1 | Terminated | Milton S. Hershey Medical Center | 4 | 2022-12-09 | 2026-09-24 |
| Angiotensin (1-7) for the Treatment of COVID-19 in Hospitalized Patients Angiotensin-(1-7), Placebo - Covid19 | Phase 1 / Phase 2 | Withdrawn | Stanford University | 2022-02-01 | 2022-03-03 | |
| TXA127 for the Treatment of Severe COVID-19 TXA127, Placebo - COVID-19 | Phase 2 | Completed | Columbia University | 22 | 2021-02-10 | 2022-07-27 |
| Use of Angiotensin-(1-7) in COVID-19 Angiotensin-(1-7), Placebo - Infection, Coronavirus, Respiratory Failure | Phase 1 / Phase 2 | Completed | Erasme University Hospital | 112 | 2020-08-05 | 2021-11-09 |
| Angiotensin-(1-7) and Energy Expenditure in Human Obesity Angiotensin-(1-7), Saline - Obesity | Early Phase 1 | Completed | Amy Arnold | 27 | 2019-09-26 | 2026-09-24 |
| Angiotensin 1-7 in Obesity Hypertension Angiotensin-(1-7), Saline - Obesity, Hypertension | Early Phase 1 | Terminated | Amy Arnold | 8 | 2019-04-01 | 2024-06-10 |
| Evaluation of the Safety and Efficacy of Ang-(1-7) to Enhance Cognitive Function in Participants Undergoing CABG Angiotensin-(1-7), Placebo for Angiotensin-(1-7) - Coronary Artery Bypass Surgery, Cognitive Impairment | Phase 2 | Terminated | University of Arizona | 6 | 2017-07-20 | 2025-06-04 |
| Angiotensin (1-7) Treatment to Improve Cognitive Functioning in Heart Failure Patients Angiotensin-(1-7), Memory Training - Chronic Heart Failure, Cognitive Impairment | Phase 2 | Suspended | University of Arizona | 6 | 2016-04-01 | 2025-06-04 |
| Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure Angiotensin-(1-7), Saline - Autonomic Nervous System Disorders, Pure Autonomic Failure | Early Phase 1 | Terminated | Vanderbilt University Medical Center | 7 | 2016-02-01 | 2021-01-12 |
| Metabolic Effects of Angiotensin-(1-7) Angiotensin-(1-7), Saline - Obesity, Insulin Resistance | Phase 1 | Recruiting | Vanderbilt University | 26 | 2016-02-01 | 2026-05-22 |
| Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension Angiotensin (1-7), Trimethaphan, Phenylephrine - Hypertension, Hypertension, Essential | Phase 1 | Terminated | Vanderbilt University | 24 | 2015-01-01 | 2024-01-09 |
Hypertension (5) · Obesity (4) · COVID-19 (2) · Cognitive Dysfunction (2) · Acute Kidney Injury (1) · Autonomic Nervous System Diseases (1) · Coronavirus Infections (1) · Dmd-Associated Dilated Cardiomyopathy (1) · Essential Hypertension (1) · Insulin Resistance (1) · Metabolic Syndrome (1) · Multiple Organ Failure (1) · Pure Autonomic Failure (1) · Respiratory Insufficiency (1) · Shy-Drager Syndrome (1)
Amy Arnold (2) · Milton S. Hershey Medical Center (2) · University of Arizona (2) · Vanderbilt University (2) · Columbia University (1) · Constant Therapeutics LLC (1) · Erasme University Hospital (1) · Stanford University (1) · Vanderbilt University Medical Center (1)
United States (11) · Brazil (1) · Israel (1)
Amy Arnold, PhD (2) · Italo Biaggioni, MD (2) · Nancy K Sweitzer, MD, PhD (2) · Alfredo Gamboa, MD (1) · Amy C Arnold, Ph.D. (1) · Amy C Arnold, PhD (1) · Ana Martins Valle (1) · Filippo Annoni (1) · Jeanine D'Armiento, MD, PhD (1) · Kevin V Grimes, MD (1) · Richard L Franklin, MD, PhD (1) · Robson AS Santos (1)
K99HL159272 (1), R01HL170140 (1), U01HL131014 (1)