17 completed, 2 terminated, 1 enrolling by invitation, 1 recruiting. 12 Not applicable, 6 Phase 2, 3 Phase 3, 2 Phase 1, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 11, Terminated 1 |
| Phase 2 | 6 | Completed 4, Enrolling by invitation 1, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 2 |
| Early Phase 1 | 1 | Recruiting 1 |
Follow acipimox: new trials by email Literature Review of acipimox trials Research Report on acipimox
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Glucose and Glycogen Dynamics in Prediabetes Acipimox 250 mg Oral Capsule - Pre Diabetes | Unknown | Maastricht University Medical Center | 45 | 2024-02-20 | 2024-04-09 | |
| Ketones, SGLT2, HFrEF Empagliflozin 25 MG Oral Tablet, Placebo, Acipimox 250 Mg Oral Capsule - Type2diabetes, Heart Failure With Reduced Ejection Fraction | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 71 | 2024-01-25 | 2026-02-05 |
| Can the Health Benefits of a Walking-based Exercise Programme be Enhanced by Co-ingestion of a Lipid-lowering Drug? Exercise Program, DXA, MRI - Pre-diabetes | Not applicable | Completed | Liverpool John Moores University | 15 | 2020-01-06 | 2024-01-03 |
| Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance Acipimox, Placebo - Impaired Mitochondrial Function, Muscle Performance | Not applicable | Terminated | University of Exeter | 2 | 2018-03-07 | 2019-09-27 |
| Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men Acipimox, placebo - Impaired Mitochondrial Function, Muscle Performance | Not applicable | Completed | Royal Devon and Exeter NHS Foundation Trust | 16 | 2016-11-08 | 2020-03-10 |
| The Effect of Acipimox on GLP (Glucagon-like Peptide)-1 Secretion Acipimox - Diabetes Mellitus Type 2 | Not applicable | Completed | University of Aarhus | 8 | 2016-06-01 | 2018-05-08 |
| Lipolytic Effects of GH in Hypopituitary Patients in Vivo Acipimox, Placebo, GH substitution - Hypopituitarism, Insulin Resistance | Not applicable | Completed | University of Aarhus | 9 | 2016-02-10 | 2020-03-26 |
| The Impact of Free Fatty Acid (FFA-) Suppression on Myocardial Lipids and Function in Patients With Type 2 Diabetes acipimox, Placebo Oral Capsule - Type 2 Diabetes | Phase 2 / Phase 3 | Completed | Medical University of Vienna | 8 | 2013-10-01 | 2017-04-04 |
| The Effect of Pharmacological Antilipolysis on the Metabolic Effects of Ghrelin Acipimox, Ghrelin, Placebo - Metabolism, Insulin Resistance | Not applicable | Completed | University of Aarhus | 8 | 2012-06-01 | 2017-10-30 |
| Effects of Acipimox on Mitochondrial Function in Obesity Acipimox, Placebo - Abdominal Obesity, Insulin Resistance | Phase 2 | Completed | Massachusetts General Hospital | 39 | 2012-05-01 | 2016-03-01 |
| Evaluating the Effects of a Study Medication on Exercise Function in Type 2 Diabetes Acipimox, Placebo - Type 2 Diabetes | Not applicable | Completed | University of Colorado, Denver | 13 | 2011-06-01 | 2021-12-03 |
| Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes Acipimox, Placebo - Type 1 Diabetes | Phase 3 | Completed | University of Colorado, Denver | 28 | 2011-06-01 | 2022-01-21 |
| Effect of Pharmacological Anti-lipolysis on FFA and VLDL-TG Metabolism Before and During Exercise Acipimox - Diabetes, Obesity | Not applicable | Completed | University of Aarhus | 9 | 2011-04-01 | 2012-09-18 |
| The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity 72 hour fast, control, 12 hour fast, Growth hormone - Healthy | Not applicable | Completed | University of Aarhus | 19 | 2011-01-01 | 2014-05-26 |
| Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function Acipimox, Cellulosum Mycrocryst - Diabetes Mellitus, Type 2, Cardiomyopathy, Dilated | Not applicable | Completed | Maastricht University Medical Center | 31 | 2010-03-01 | 2013-05-14 |
| Effect of 4 Weeks Treatment With Acipimox in Patients With Chronic Heart Failure acipimox, placebo - Heart Failure | Not applicable | Completed | University of Aarhus | 28 | 2007-10-01 | 2009-10-07 |
| Metabolic Modulation as Treatment in Acute Heart Failure acipimox - Acute Heart Failure | Phase 2 | Terminated | University of Aarhus | 32 | 2007-03-01 | 2007-10-25 |
| The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome acipimox, Placebo - Metabolic Syndrome | Phase 2 / Phase 3 | Completed | Brigham and Women's Hospital | 40 | 2006-04-01 | 2023-02-21 |
| In Vivo Specificity of KUC 7483 CL Co-administered With Bisoprolol, Propranolol, and Acipimox in Healthy Male Subjects KUC 7483 CL, Bisoprolol, Propranolol - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 12 | 2005-10-01 | 2014-10-06 |
| Free Fatty Acids and Vascular Function in Subjects With Diabetes acipimox, placebo - Type 2 Diabetes Mellitus | Phase 1 / Phase 2 | Completed | Brigham and Women's Hospital | 40 | 2005-09-01 | 2018-09-25 |
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Insulin Resistance (8) · Diabetes Mellitus, Type 2 (6) · Diabetes Mellitus (4) · Glucose Intolerance (2) · Hypertriglyceridemia (2) · Hypopituitarism (2) · Motor Activity (2) · Brain Diseases (1) · Bulimia Nervosa (1) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Cardiovascular Diseases (1) · Diabetes Mellitus, Type 1 (1) · Endocrine System Diseases (1) · Feeding and Eating Disorders (1)
University of Aarhus (7) · Brigham and Women's Hospital (2) · Maastricht University Medical Center (2) · University of Colorado, Denver (2) · Boehringer Ingelheim (1) · Charles University, Czech Republic (1) · Liverpool John Moores University (1) · Massachusetts General Hospital (1) · Medical University of Vienna (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Royal Devon and Exeter NHS Foundation Trust (1) · The University of Texas Health Science Center at San Antonio (1) · University of Exeter (1)
Denmark (7) · United States (7) · United Kingdom (3) · Netherlands (2) · Austria (1)
Colleen Deane, PhD (1) · Colleen M. Hadigan, MD (1) · Irene Schauer, M.D., Ph.D. (1) · Irene Schauer, MD, PhD (1) · Joshua A. Beckman, M.D. (1) · Kvido Smitka, M.D., Ph.D. (1) · Mads Halbirk (1) · Mads Halbirk, dr. (1) · Mark Creager, M.D. (1) · Michael Krebs, Prof.MD (1) · Patrick Schrauwen, PhD (1) · Ralph DeFronzo, MD (1) · Soren Nielsen, Dr. med. (1)
PMID 16940448, PMID 24310562, PMID 26691888, PMID 28736944, PMID 30576246, PMID 31571412, PMID 31608930, PMID 32945898, PMID 33258025, PMID 39888728
R01DK107680 (1), R21HL073675 (1)