6 completed, 3 terminated, 1 recruiting, 1 unknown. 11 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 6, Terminated 3, Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
Follow Acetylcholine: new trials by email Literature Review of Acetylcholine trials Research Report on Acetylcholine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HeartPhone Cancer Survivors Trial 2019 HeartPhone app, Acetylcholine, Sodium Nitroprusside - Breast Cancer, Leukemia | Phase 1 / Phase 2 | Terminated | Penn State University | 2 | 2019-04-23 | 2026-02-27 |
| Pharmacodynamic Study to Assess the Effects of Repeated Dosing of SAR247799 on Endothelial Function in Patients With Type 2 Diabetes Mellitus SAR247799, Placebo, Sildenafil - Microvascular Coronary Artery Disease | Phase 1 | Completed | Sanofi | 54 | 2018-03-07 | 2022-04-25 |
| Endothelial Injury and Development of Coronary Intimal Thickening After Heart Transplantation Optical Coherence Tomography, Acetylcholine, Brachial Artery Flow Mediated Dilation - Cardiac Allograft Vasculopathy, Antibody Mediated Rejection | Phase 1 | Terminated | Gladwin, Mark, MD | 12 | 2012-09-01 | 2017-09-06 |
| Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis Acetylcholine and Blood - Healthy | Phase 1 | Completed | Mark Gladwin | 53 | 2010-04-01 | 2015-04-14 |
| : Vascular Function in Health and Disease Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123 - Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension | Phase 1 | Recruiting | D. Walter Wray | 420 | 2008-09-01 | 2026-09-25 |
| Model System for Transient Forearm Blood Vessel Dysfunction Limb Ischemia, Acetylcholine - Limb Ischemia, Ischemic Preconditioning | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 6 | 2007-03-26 | 2022-08-09 |
| Sildenafil to Treat HIV-Associated Pulmonary Hypertension MRI, L-NMMA, Acetylcholine - HIV | Phase 1 | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 20 | 2006-05-12 | 2019-12-17 |
| The Role of Nitrite in Preconditioning Mediated Tolerance to Ischemic Stress Sodium Nitrate, Acetylcholine - Ischemic Stress, Transient Non-Lethal Ischemia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 135 | 2005-11-01 | 2017-07-02 |
| The Effect of Lopinavir/Ritonavir on Endothelial Function Acetylcholine, L-NMMA - Healthy | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 30 | 2004-01-01 | 2008-03-04 |
| Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease Oxypurinol, L-NMMA, Acetylcholine - Sickle Cell Disease | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 44 | 2003-11-04 | 2019-12-12 |
| Vasoreactivity in Carriers of Genetic Polymorphisms sodium nitroprusside, bradykinin, acetylcholine - Healthy | Phase 1 | Unknown | Heidelberg University | 100 | 1999-11-01 | 2005-09-12 |
Acquired Immunodeficiency Syndrome (1) · Anemia, Sickle Cell (1) · Breast Neoplasms (1) · Familial Primary Pulmonary Hypertension (1) · HIV Infections (1) · Heart Failure (1) · Hypertension (1) · Hypertension, Pulmonary (1) · Inflammation (1) · Leukemia (1) · Lymphoma (1) · Pulmonary Disease, Chronic Obstructive (1)
National Heart, Lung, and Blood Institute (NHLBI) (3) · National Institutes of Health Clinical Center (CC) (2) · D. Walter Wray (1) · Gladwin, Mark, MD (1) · Heidelberg University (1) · Mark Gladwin (1) · Penn State University (1) · Sanofi (1)
United States (9) · Germany (2)
Catalin Toma, MD (1) · David W Wray, Ph.D. (1) · Henry Masur, M.D. (1) · John F Tisdale, M.D. (1) · Mark T Gladwin, M.D (1) · Walter E Haefeli, MD (1)
2017 (1), R01HL098032 (1)