47 completed, 22 unknown, 10 terminated, 5 withdrawn. 30 Phase 2, 21 Not applicable, 19 Phase 4, 17 Phase 3, 14 Phase 1.
Follow 0.9% Normal Saline: new trials by email Literature Review of 0.9% Normal Saline trials Research Report on 0.9% Normal Saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity. Semaglutide, Placebo - Type 1 Diabetes, Overweight , Obesity | Phase 2 / Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 40 | 2026-10-13 | 2026-10-23 |
| The Effect of Perioperative Intravenous Lidocaine Infusion on Post-amputation Pain in Amputee Patients Lidocaine Hydrochloride, Injectable, 0.9% normal saline - Amputation | Not applicable | Not yet recruiting | West China Hospital | 200 | 2026-10-01 | 2026-08-25 |
| Efficacy of Oral HA35 for Rapid Relief of Oral Pain and Pungent Sensation Capsaicin Oral Challenge, Allyl Isothiocyanate (AITC) Oral Challenge, 10% 35 kDa Hyaluronan (HA35) Oral Solution - Oral Pain, Oral Pungent Sensation | Not applicable | Completed | Nakhia Impex LLC | 30 | 2026-06-05 | 2026-09-10 |
| Use of Preoperative Sodium Bicarbonate Among Women With Obstructed Labor 8.4% sodium bicarbonate solution, 0.9% Normal Saline - Obstructed Labor | Phase 3 | Completed | Busitema University | 472 | 2025-05-06 | 2026-04-20 |
| Dexamethasone Versus Metoclopramide for Prophylaxis of Nausea and Vomiting After Cataract Surgery 0.9% normal saline, Metoclopramide 10mg, Dexamethasone - Cataract, Dexamethasone | Not applicable | Completed | Alexandria University | 210 | 2025-05-01 | 2026-10-21 |
| A Study of NCR100 Injection for the Treatment of Knee Osteoarthritis（ KOA） NCR100, 0.9% Normal saline - Knee Osteoarthritis | Phase 1 / Phase 2 | Not yet recruiting | Nuwacell Biotechnologies Co., Ltd. | 162 | 2025-02-20 | 2024-12-18 |
| A Clinical Study of HH-006 in Untreated Chronic Hepatitis B Virus Infected Patients HH-006, 0.9% normal saline - Chronic Hepatitis B Virus Infection | Phase 1 | Completed | Huahui Health | 36 | 2024-12-20 | 2026-04-07 |
| Superior Hypogastric Nerve Plexus Block With Bupivacaine After Robotic Resection of Endometriosis Bupivacaine Hydrochloride, Normal saline - Endometriosis | Phase 4 | Unknown | Baylor College of Medicine | 60 | 2024-08-28 | 2025-08-18 |
| Effect of Fluid Resuscitation on Lactate in Traumatic Injury Patients 3% hypertonic Saline, Ringer's lactated solution, 0.9% Normal saline - Fluid Resuscitation | Phase 1 / Phase 2 | Unknown | Assiut University | 150 | 2024-08-01 | 2024-04-17 |
| Nebulized Salbutamol in Acute Renal Colic Salbutamol, 0.9% Normal Saline, Diclofenac Injection - Renal Colic | Not applicable | Unknown | Oman Medical Speciality Board | 214 | 2024-07-01 | 2024-03-19 |
| Effect of Topical Insulin on Healing Rate of Pemphigus Lesions insulin glargine, human insulin, 0.9% Normal Saline - Pemphigus Vulgaris, Skin Erosion | Phase 2 | Completed | Alexandria University | 20 | 2024-06-22 | 2026-03-10 |
| Continuous Local-anesthetic Wound Infusion for Neck Dissection 0.5% Lidocaine Hydrochloride, 0.9% Normal Saline - Head and Neck Cancer | Not applicable | Unknown | Sixth Affiliated Hospital, Sun Yat-sen University | 80 | 2024-03-01 | 2024-01-11 |
| Effect of TEE-guided Non-fluid Limited Combined With Dobutamine on Hepatic Venous Blood Flow Spectrum Dobutamine hydrochloride, Injectable, 0.9% normal saline - Laparoscopic Hepatectomy | Early Phase 1 | Unknown | Sichuan University | 51 | 2024-02-01 | 2024-01-18 |
| Combined Use of Naldebain® ER Injection and Precedex® After VATS PRECEDEX INJ★ 2ML, Normal saline - Acute Post Operative Pain, Chronic Post Operative Pain | Phase 4 | Unknown | Kaohsiung Medical University Chung-Ho Memorial Hospital | 70 | 2023-12-28 | 2023-12-19 |
| Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections 6% aqueous phenol, MethylPREDNISolone 40 MG, Intraarticular Knee Placebo - Osteoarthritis, Knee, Chronic Knee Pain | Phase 4 | Unknown | University of Manitoba | 40 | 2023-10-20 | 2023-10-10 |
| A Clinical Study to Evaluate the Efficacy and Satisfaction of the Skinceuticals Skin Care Product (CE FERULIC) for Skin Repair Post Fraxel Laser Treatment Skinceuticals skin care product(CE), fraxel laser therapy, 0.9% normal saline - Photo-damaging | Not applicable | Unknown | DeYi Aesthetic Medical Clinic | 50 | 2023-09-01 | 2023-09-06 |
| A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma Xembify, Placebo - Hypogammaglobulinemia, Bacterial Infections | Phase 3 | Recruiting | Grifols Therapeutics LLC | 386 | 2022-12-26 | 2026-09-30 |
| Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery Intravenous Ascorbate, Normal Saline 10 mL Injection - Oxidative Stress, Ischemia-reperfusion Injury | Phase 3 | Unknown | University of Malaya | 34 | 2022-09-25 | 2022-11-25 |
| Investigator Initiated Trial to Evaluate Efficacy and Safety of LAENNEC (Human Placenta Hydrolysate) Administered by Ultrasonography Guided Subacromial Bursa Injection in Patients With Shoulder Impingement Syndrome LAENNEC, 0.9% normal saline - Shoulder Impingement Syndrome | Not applicable | Completed | Green Cross Wellbeing | 50 | 2022-09-13 | 2026-02-24 |
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Pain, Postoperative (12) · COVID-19 (7) · Osteoarthritis, Knee (6) · Wounds and Injuries (4) · Clostridium Infections (3) · Hemorrhage (3) · Pain (3) · Acidosis (2) · Agnosia (2) · Asthma (2) · Bronchiolitis (2) · Diarrhea (2) · Herpes Genitalis (2) · Herpes Simplex (2) · Obesity (2)
ImmuneMed, Inc. (5) · Assiut University (3) · Sanofi Pasteur, a Sanofi Company (3) · West China Hospital (3) · Alexandria University (2) · Chang Gung Memorial Hospital (2) · Genocea Biosciences, Inc. (2) · Grifols Therapeutics LLC (2) · Jazz Pharmaceuticals (2) · Mahidol University (2) · Mayo Clinic (2) · McGill University Health Centre/Research Institute of the McGill University Health Centre (2) · McMaster University (2) · Northwestern University (2) · The Catholic University of Korea (2)
United States (27) · China (11) · Canada (9) · South Korea (8) · Taiwan (5) · Egypt (4) · Russia (3) · Thailand (3) · Australia (2) · Bulgaria (2) · France (2) · Malaysia (2) · Pakistan (2) · Poland (2) · Uganda (2)
Chunling Jiang, PhD (2) · Jun-Wen Wang, MD (2) · Parameswaran Nair, MD, PhD (2) · Yong In, MD, PhD (2) · AhYoung Oh (1) · Andrew Weeks, MD (1) · Bruce D Spiess, MD, FAHA (1) · Carmen I Farid, MB BCh, MD (1) · Catherine Lemiere, MD (1) · Chris Harle, MD (1) · Dan Kibuule, PhD (1) · Daniel K Nishijima, MD, MAS (1)
PMID 17043939, PMID 18448749, PMID 21178763, PMID 21364458, PMID 22003000, PMID 23343829, PMID 23371895, PMID 23506972, PMID 25072443, PMID 25184917, PMID 26123384, PMID 26220293, PMID 26903671, PMID 27013431, PMID 27480410, PMID 28183347, PMID 28586918, PMID 28682955, PMID 28726212, PMID 28915080, PMID 29116880, PMID 30221827, PMID 30376893, PMID 30626406, PMID 30760509, PMID 30988677, PMID 31103365, PMID 31271691, PMID 31299040, PMID 31537446, PMID 32278572, PMID 34488858, PMID 34561086, PMID 35244208, PMID 35977357, PMID 36135712, PMID 36571171, PMID 37202261, PMID 37794659, PMID 37984940, PMID 39754114
2008 (1), U01HL077863 (1)