7 completed, 3 terminated, 2 recruiting, 2 unknown. 17 Phase 3, 8 Phase 2.
Follow 0.9% Normal Saline: new trials by email Literature Review of 0.9% Normal Saline trials Research Report on 0.9% Normal Saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity. Semaglutide, Placebo - Type 1 Diabetes, Overweight , Obesity | Phase 2 / Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 40 | 2026-10-13 | 2026-10-23 |
| Use of Preoperative Sodium Bicarbonate Among Women With Obstructed Labor 8.4% sodium bicarbonate solution, 0.9% Normal Saline - Obstructed Labor | Phase 3 | Completed | Busitema University | 472 | 2025-05-06 | 2026-04-20 |
| A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma Xembify, Placebo - Hypogammaglobulinemia, Bacterial Infections | Phase 3 | Recruiting | Grifols Therapeutics LLC | 386 | 2022-12-26 | 2026-09-30 |
| Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery Intravenous Ascorbate, Normal Saline 10 mL Injection - Oxidative Stress, Ischemia-reperfusion Injury | Phase 3 | Unknown | University of Malaya | 34 | 2022-09-25 | 2022-11-25 |
| Angiotensin II in Liver Transplantation Angiotensin II, Saline - Liver Transplant; Complications, Vasoplegia | Phase 2 / Phase 3 | Active not recruiting | University of California, San Francisco | 50 | 2022-06-28 | 2026-03-20 |
| Role of Granisetron in Preventing Hypotension After Spinal Anesthesia With Levobupivacaine in Rheumatic Patients Undergoing Elective Cesarean Section Granisetron Hydrochloride, 0.9% normal saline - Granisetron | Phase 2 / Phase 3 | Unknown | Assiut University | 102 | 2022-04-01 | 2022-04-06 |
| Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Gemcitabine and Carboplatin for Metastatic Triple-Negative Breast Cancer (TNBC) Trilaciclib, Placebo, Gemcitabine - TNBC - Triple-Negative Breast Cancer, Breast Cancer | Phase 3 | Completed | G1 Therapeutics, Inc. | 194 | 2021-05-14 | 2024-08-01 |
| Dociparstat in Combination With Standard Chemotherapy for the Treatment of Acute Myeloid Leukemia Dociparstat, Control - Acute Myeloid Leukemia | Phase 3 | Terminated | Jazz Pharmaceuticals | 9 | 2021-04-30 | 2024-04-15 |
| Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure Dociparstat sodium, Placebo - Coronavirus Disease 2019 (COVID-19), Acute Lung Injury | Phase 2 / Phase 3 | Terminated | Jazz Pharmaceuticals | 27 | 2020-07-08 | 2022-08-30 |
| Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma Tranexamic Acid, 0.9% Normal Saline - Effect of Drugs, Adverse Effects of Medical Drugs | Phase 2 / Phase 3 | Completed | Jinnah Postgraduate Medical Centre | 30 | 2018-09-01 | 2019-12-17 |
| Anti-Interleukin-5 (IL5) Monoclonal Antibody (MAb) in Prednisone-dependent Eosinophilic Asthma Reslizumab, Placebo - Severe Persistent Asthma, Eosinophilic Bronchitis | Phase 2 / Phase 3 | Completed | McMaster University | 10 | 2015-10-01 | 2018-04-04 |
| Pre-Hospital Use of Plasma for Traumatic Hemorrhage Plasma, Normal saline - Shock, Hemorrhagic | Phase 2 / Phase 3 | Withdrawn | Virginia Commonwealth University | 2014-11-01 | 2016-02-23 | |
| "Palivizumab Therapy for RSV-bronchiolitis" Palivizumab, Placebo - Respiratory Syncytial Virus-bronchiolitis | Phase 3 | Completed | Hamad Medical Corporation | 420 | 2014-09-01 | 2018-02-27 |
| Study of the Steroid Sparing Effect of Xolair (Omalizumab) in Patients With Persistent Eosinophilic Bronchitis Omalizumab (Xolair), Placebo - Steroid and/or Prednisone Dependent Asthma, Eosinophilic Bronchitis | Phase 2 / Phase 3 | Completed | McMaster University | 11 | 2014-03-01 | 2018-04-04 |
| Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis 3% Saline, 0.9% Normal Saline - Acute Viral Bronchiolitis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 778 | 2012-10-01 | 2014-07-28 |
| Hypertonic Resuscitation Following Traumatic Injury 7.5% hypertonic saline/6% Dextran-70 (HSD), 7.5% hypertonic saline (HS), 0.9% normal saline - Shock, Traumatic | Phase 3 | Terminated | University of Washington | 895 | 2006-05-01 | 2011-03-01 |
Asthma (2) · Bronchiolitis (2) · Shock (2) · Wounds and Injuries (2) · Acute Kidney Injury (1) · Acute Lung Injury (1) · Agammaglobulinemia (1) · Bacterial Infections (1) · Breast Neoplasms (1) · Bronchial Diseases (1) · Bronchiolitis, Viral (1) · Bronchitis (1) · COVID-19 (1) · Diabetes Mellitus, Type 1 (1) · Dystocia (1)
Assiut University (2) · Jazz Pharmaceuticals (2) · McMaster University (2) · Assistance Publique - Hôpitaux de Paris (1) · Busitema University (1) · G1 Therapeutics, Inc. (1) · Grifols Therapeutics LLC (1) · Hamad Medical Corporation (1) · Jinnah Postgraduate Medical Centre (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · University of California, San Francisco (1) · University of Malaya (1) · University of Washington (1) · Virginia Commonwealth University (1)
United States (7) · Canada (4) · Bulgaria (2) · France (2) · Poland (2) · Australia (1) · Bosnia and Herzegovina (1) · China (1) · Croatia (1) · Egypt (1) · Georgia (1) · Hungary (1) · Malaysia (1) · Moldova (1) · Pakistan (1)
Parameswaran Nair, MD, PhD (2) · Andrew Weeks, MD (1) · Bruce D Spiess, MD, FAHA (1) · Catherine Lemiere, MD (1) · Dan Kibuule, PhD (1) · David Mukunya, PhD (1) · Delbert Dorscheid, MD (1) · Dr. Khalid Alansari (1) · Julius Wandabwa, PhD (1) · Kenneth Mugabe, MD (1) · Louis-Philippe Boulet, MD (1) · Melissa-Rosina Pasqua, MD, PhD (1) · Michael P Bokoch, M.D., Ph.D. (1) · Myron L Weisfeldt, MD (1)
PMID 21178763, PMID 25072443, PMID 25184917, PMID 26220293, PMID 28183347, PMID 28586918, PMID 28726212, PMID 28915080, PMID 30760509, PMID 30988677, PMID 35244208, PMID 36135712, PMID 37984940
U01HL077863 (1)