17 completed, 2 unknown, 1 enrolling by invitation, 1 not yet recruiting. 7 Phase 1, 2 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 7 |
| Not applicable | 2 | Not yet recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
Follow Zika Virus: new trials by email Literature Review of Zika Virus trials Research Report on Zika Virus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases Peripheral venous blood sample - Leishmaniasis, Leptospirosis | Not applicable | Not yet recruiting | University Hospital, Montpellier | 183 | 2025-03-03 | 2025-03-05 |
| Evaluation of the Protective Efficacy of TV003 or Previous Zika Infection Against Infection With ZIKV-SJRP Challenge Compared to DENV and ZIKV-naïve Controls Against Infection With ZIKV-SJRP Challenge TetraVax-DV-TV003 (TV003), Plasmalyte, Challenge virus ZIKV-SJRP/2016-184 - Zika Virus | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 27 | 2024-09-24 | 2026-03-09 |
| Evaluation of Two Zika Viruses for Use in Controlled Human Infection Models (CHIM) ZIKV-SJRP/2016-184 Strain, Experimental: ZIKV-Nicaragua/2016 Strain, Placebo - Zika Virus | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 56 | 2022-02-16 | 2025-04-11 |
| A Study of Zika Vaccine mRNA-1893 in Adult Participants Living in Endemic and Non-Endemic Flavivirus Areas mRNA-1893, Placebo - Zika Virus | Phase 2 | Completed | ModernaTX, Inc. | 808 | 2021-06-07 | 2025-09-25 |
| Neurodevelopmental Outcomes in ZIKV-Exposed Children Neurodevelopmental assessments - Zika Virus, Congenital Zika Syndrome | Enrolling by invitation | Children's National Research Institute | 204 | 2020-11-23 | 2025-07-03 | |
| Evaluation of Medical Conditions Associated With Zika Virus Infection in Managua, Nicaragua Zika Virus | Completed | RTI International | 410 | 2019-10-01 | 2024-12-04 | |
| Safety, Tolerability, and Immunogenicity of Zika Vaccine mRNA-1893 in Healthy Flavivirus Seropositive and Seronegative Adults mRNA-1893, Placebo - Zika Virus | Phase 1 | Completed | ModernaTX, Inc. | 120 | 2019-07-30 | 2024-08-21 |
| Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults Single dose of rZIKV/D4Δ30-713 (10^3 PFU) via subcutaneous injection (0.5ml), Single dose of placebo via subcutaneous injection (0.5ml)., Single dose of rZIKV/D4Δ30-713 (10^4 PFU) via subcutaneous injection (0.5ml) - Zika Virus | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 56 | 2018-07-06 | 2025-08-05 |
| ZIKAlliance Natural History Study Zika Virus, Zika Virus Infection | Withdrawn | University of Heidelberg Medical Center | 2018-04-01 | 2022-05-18 | ||
| Randomized, Placebo-controlled, Observer-blinded Phase 1 Safety and Immunogenicity Study of Inactivated Zika Virus Vaccine Candidate in Healthy Adults VLA1601, Placebo - Zika Virus, Zika Virus Infection | Phase 1 | Completed | Valneva Austria GmbH | 67 | 2018-02-24 | 2019-07-05 |
| ZIKAlliance Children Cohort (ZIKAllianceCH) Zika Virus | Completed | University of Heidelberg Medical Center | 1554 | 2018-01-15 | 2022-05-18 | |
| Prospective Cohort Study of HIV and Zika in Infants and Pregnancy HIV, Zika Virus | Completed | Westat | 395 | 2017-08-23 | 2022-01-14 | |
| Study on the Persistence of Zika Virus (ZIKV) in Body Fluids of Patients With ZIKV Infection in Brazil RT-PCR - Zika Virus | Completed | Oswaldo Cruz Foundation | 260 | 2017-07-21 | 2021-03-03 | |
| Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome posture adapter - Zika Virus | Not applicable | Unknown | Universidade Federal de Pernambuco | 20 | 2017-07-20 | 2017-07-24 |
| ZIKAlliance Pregnant Women Cohort Zika Virus, Pregnancy Related | Completed | University of Heidelberg Medical Center | 3852 | 2017-05-24 | 2022-05-24 | |
| Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability (V186-001) MV-ZIKA, Placebo - Zika Virus | Phase 1 | Completed | Themis Bioscience GmbH | 48 | 2017-05-03 | 2022-08-18 |
| VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents VRC-ZKADNA090-00-VP, VRC-PBSPLA043-00-VP - Zika Virus, Zika Virus Infection | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2428 | 2017-03-29 | 2024-01-31 |
| Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects mRNA-1325, Placebo - Zika Virus | Phase 1 | Completed | ModernaTX, Inc. | 90 | 2016-12-21 | 2024-08-21 |
| Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection Semen analysis and semen PCR for Zika virus - Zika Virus | Completed | Trinidad and Tobago IVF and Fertility Centre | 25 | 2016-07-01 | 2018-05-07 | |
| Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD) Zika Virus, Dengue Virus | Completed | National Institutes of Health Clinical Center (CC) | 34 | 2016-06-08 | 2019-03-18 |
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Zika Virus Infection (22) · Chikungunya Fever (5) · Dengue (3) · Arthralgia (1) · Brucellosis (1) · Encephalitis, Tick-Borne (1) · Fever (1) · Flaviviridae Infections (1) · Flavivirus Infections (1) · Hantavirus Pulmonary Syndrome (1) · Hepatitis E (1) · Leishmaniasis (1) · Leptospirosis (1) · Lyme Disease (1) · Psittacosis (1)
Arbovirus Infections (22) · Infections (22) · Mosquito-Borne Diseases (22) · Vector Borne Diseases (22) · Flaviviridae Infections (21) · Flavivirus Infections (21) · RNA Virus Infections (21) · Virus Diseases (21) · Alphavirus Infections (5) · Togaviridae Infections (5) · Hemorrhagic Fevers, Viral (3) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Body Temperature Changes (1) · Borrelia Infections (1)
COVID-19 Nucleic Acid Testing (1) · GLS-5700 vaccine (1) · Plasmalyte A (1) · Semen Analysis (1)
National Institute of Allergy and Infectious Diseases (NIAID) (4) · ModernaTX, Inc. (3) · University of Heidelberg Medical Center (3) · Children's National Research Institute (1) · Institute of Tropical Medicine, Belgium (1) · National Institutes of Health Clinical Center (CC) (1) · Oswaldo Cruz Foundation (1) · RTI International (1) · Themis Bioscience GmbH (1) · Trinidad and Tobago IVF and Fertility Centre (1) · Universidade Federal de Pernambuco (1) · University Hospital Center of Martinique (1) · University Hospital, Montpellier (1) · Valneva Austria GmbH (1) · Westat (1)
United States (11) · Brazil (7) · Colombia (4) · Puerto Rico (4) · Guadeloupe (3) · Mexico (3) · Bolivia (2) · Cuba (2) · France (2) · Venezuela (2) · Austria (1) · Belgium (1) · Costa Rica (1) · Ecuador (1) · French Guiana (1)
Anna Durbin, MD (2) · Andre Cabie, MD (1) · Anna Durbin, M.D. (1) · Catherine Minto-Bain, MB ChB MRCOG (1) · Emmanuel Bottieau, MD PhD (1) · Guilherme A Calvet, MD,PhD (1) · Jill F. Lebov, PhD (1) · Julie Ledgerwood, DO (1) · Katrin Dubischar (1) · Kristen Pierce, MD (1) · Marcus VG Lacerda, MD,PhD (1) · Marisa M. Mussi-Pinhata, MD (1)
PMID 31878895, PMID 36682364, PMID 30476967, PMID 31002058, PMID 31904798, PMID 32163420, PMID 32274991, PMID 33400705, PMID 33503145, PMID 33872214, PMID 34962177, PMID 36446920, PMID 37068115, PMID 38244996, PMID 38392908, PMID 38438554, PMID 38970708, PMID 39057769, PMID 40108430
2016 (1), R01HD102445 (1), R21AI139777 (1), R21HD095420 (1)