4 completed, 4 unknown, 2 not yet recruiting. 4 Not applicable, 3 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 2, Not yet recruiting 1, Unknown 1 |
| Phase 1 | 3 | Unknown 2, Completed 1 |
| Phase 2 | 3 | Unknown 2, Not yet recruiting 1 |
Follow Xerostomia Due to Radiotherapy: new trials by email Literature Review of Xerostomia Due to Radiotherapy trials Research Report on Xerostomia Due to Radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy ORAL CARE PRODUCT KIT - Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation | Not applicable | Not yet recruiting | UNCANCER LLC | 50 | 2026-11-01 | 2026-10-21 |
| Repeated Mesenchymal Stem Cell Therapy for Radiation-Induced Hyposalivation and Xerostomia in Head and Neck Cancer Survivors ALLOGENEIC AND EXPANDED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS, Placebo - Xerostomia Due to Hyposecretion of Salivary Gland, Xerostomia Due to Radiotherapy | Phase 2 | Not yet recruiting | Christian von Buchwald | 100 | 2025-12-01 | 2025-12-18 |
| Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy: a Multi-centric Cross-sectional Study Radiotherapy Side Effect, Xerostomia Due to Radiotherapy | Completed | Ain Shams University | 260 | 2023-03-20 | 2025-02-28 | |
| Mesenchymal Stem Cells for Radiation-induced Xerostomia Autologous adipose-derived mesenchymal stem/stromal cells, Placebo - Radiation Toxicity, Xerostomia Due to Radiotherapy | Phase 1 / Phase 2 | Unknown | Copenhagen University Hospital, Rigshospitalet | 30 | 2020-08-01 | 2020-10-22 |
| MRI - Guided Adaptive RadioTHerapy for Reducing XerostomiA in Head and Neck Cancer (MARTHA-trial) Pre-defined MR-linac based IGRT and plan adaptation protocol, salivary flow measurements - Head and Neck Cancer, Xerostomia Due to Radiotherapy | Not applicable | Completed | Panagiotis Balermpas | 49 | 2019-10-15 | 2026-08-03 |
| A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia AAV2hAQP1: 1 x 10^11 vg/gland (single gland), AAV2hAQP1: 3 x 10^10 vg/gland (both glands), AAV2hAQP1: 3 x 10^11 vg/gland (single gland) - Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy | Phase 1 | Completed | MeiraGTx UK II Ltd | 24 | 2019-06-30 | 2023-04-24 |
| Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth Allogeneic adipose derived stem/stromal cells - Xerostomia Due to Radiotherapy, Hyposalivation | Phase 1 | Unknown | Copenhagen University Hospital, Rigshospitalet | 10 | 2019-03-18 | 2021-01-29 |
| Clinical Trial to Evaluate the Effect and Safety of MSV in Xerostomy mesenchymal cells - Xerostomia Due to Radiotherapy | Phase 2 | Unknown | Institut de Terapia Regenerativa Tissular | 10 | 2018-12-15 | 2018-11-16 |
| Finger-prick Autologous Blood (FAB) for Use in Dry Mouth Finger-prick Autologous Blood (FAB) - Xerostomia, Xerostomia Due to Radiotherapy | Not applicable | Unknown | Bedford Hospital NHS Trust | 20 | 2018-09-01 | 2018-07-27 |
| Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx Parotid-Sparing Head & Neck Radiation Guided by MRI Sialography - Head and Neck Cancer, Oropharynx Cancer | Not applicable | Completed | UNC Lineberger Comprehensive Cancer Center | 40 | 2018-03-08 | 2023-05-31 |
Head and Neck Neoplasms (5) · Xerostomia (5) · Radiation Injuries (3) · Oropharyngeal Neoplasms (2) · Long Term Adverse Effects (1) · Neoplasms (1) · Salivary Gland Diseases (1) · Sjogren's Syndrome (1) · Stomatitis (1) · Ulcer (1)
Stomatognathic Diseases (7) · Mouth Diseases (6) · Neoplasms (6) · Neoplasms by Site (6) · Salivary Gland Diseases (4) · Wounds and Injuries (3) · Otorhinolaryngologic Diseases (2) · Otorhinolaryngologic Neoplasms (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Pharyngeal Diseases (2) · Pharyngeal Neoplasms (2) · Arthritis (1) · Arthritis, Rheumatoid (1) · Autoimmune Diseases (1)
Copenhagen University Hospital, Rigshospitalet (2) · Ain Shams University (1) · Bedford Hospital NHS Trust (1) · Christian von Buchwald (1) · Institut de Terapia Regenerativa Tissular (1) · MeiraGTx UK II Ltd (1) · Panagiotis Balermpas (1) · UNC Lineberger Comprehensive Cancer Center (1) · UNCANCER LLC (1)
United States (3) · Denmark (2) · Canada (1) · Egypt (1) · Spain (1) · Switzerland (1)
Charlotte Lynggaard, MD (2) · Christian von Buchwald, MD, Professor (1) · David V. Fried, PhD (1) · Panagiotis Balermpas, M.D. (1)
2014 (1), 2018 (1), 2025 (1)