3 completed, 3 not yet recruiting, 3 recruiting, 3 unknown. 6 Phase 2, 3 Not applicable, 3 Phase 1.
Follow Vulvar Squamous Cell Carcinoma: new trials by email Literature Review of Vulvar Squamous Cell Carcinoma trials Research Report on Vulvar Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sac-TMT in Vaginal and Vulvar Cancers Sacituzumab Tirumotecan (sac-TMT) - Vaginal Squamous Cell Carcinoma, Vulvar Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Latin American Cooperative Oncology Group | 48 | 2027-01-01 | 2026-09-04 |
| Evaluation of a Point-of-Care, AI-Powered Spectroscopy Device for Triage of Suspicious Vulvar Lesions: A Pilot Study Non-Interventional Study - Vulvar Intraepithelial Neoplasia, HPV-Independent, Vulvar Squamous Cell Carcinoma | Recruiting | Mayo Clinic | 20 | 2026-10-06 | 2026-10-21 | |
| Safety and Efficacy of Nivolumab and Imiquimod Combination in Vulvar Squamous Cell Carcinoma Patients Imiquimod 5% cream, Nivolumab - Vulvar Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Centre Leon Berard | 50 | 2026-09-01 | 2026-09-30 |
| A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas EVOLVE104 - Bladder Cancer, Squamous Cell Carcinoma of the Lung | Phase 1 | Recruiting | EvolveImmune United, Inc | 160 | 2025-11-13 | 2026-09-15 |
| In Vitro Study of [18F]F-FAPI-74 Feasibility in Vulvar Cancer Vulvar Squamous Cell Carcinoma | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 90 | 2025-04-01 | 2025-04-04 | |
| STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision Surgery, Active Surveillance - Vulvar Squamous Cell Carcinoma | Not applicable | Recruiting | Canadian Cancer Trials Group | 249 | 2024-12-10 | 2026-08-11 |
| A Safety and Efficacy Study of Intra-tumoural Diffusing Alpha Radiation Emitters for the Treatment of Vulva Cancer DaRT Diffusing Alpha-emitters Radiation Therapy - Vulva Cancer, Recurrent, Vulvar Squamous Cell Carcinoma | Not applicable | Unknown | CCTU- Cancer Theme | 10 | 2023-02-28 | 2023-05-25 |
| Cisplatin+Pembrolizumab+RT in Vulvar Cancer Cisplatin, Pembrolizumab, Radiation Therapy - Vulvar Cancer, Vulvar Squamous Cell Carcinoma | Phase 2 | Active not recruiting | Massachusetts General Hospital | 24 | 2020-07-29 | 2026-05-05 |
| Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers Durvalumab, Laboratory Biomarker Analysis, Stereotactic Radiosurgery - Advanced Cervical Adenocarcinoma, Advanced Vaginal Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 20 | 2018-07-18 | 2023-09-13 |
| Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Biopsy Procedure, Biospecimen Collection, Computed Tomography - Anaplastic Large Cell Lymphoma, ALK-Negative, Anaplastic Large Cell Lymphoma, ALK-Positive | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 68 | 2017-09-27 | 2026-08-13 |
| Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer Biospecimen Collection, Laboratory Biomarker Analysis - Cervical Adenocarcinoma, Cervical Adenocarcinoma In Situ | Not applicable | Terminated | M.D. Anderson Cancer Center | 409 | 2014-10-27 | 2025-07-14 |
| Radiation Therapy, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Locally Advanced Squamous Cell Cancer of the Vulva Cisplatin, Gemcitabine Hydrochloride, Intensity-Modulated Radiation Therapy - Stage III Vulvar Cancer AJCC v7, Stage IIIA Vulvar Cancer AJCC v7 | Phase 2 | Unknown | Gynecologic Oncology Group | 57 | 2012-07-02 | 2021-12-29 |
| Observation in Patients With Early-Stage Vulvar Cancer Undergoing Sentinel Lymph Node Dissection Clinical Observation - Stage I Vulvar Cancer, Stage II Vulvar Cancer | Unknown | Gynecologic Oncology Group | 148 | 2012-01-03 | 2021-09-30 | |
| Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Cancer of the Vulva 3-Dimensional Conformal Radiation Therapy, Cisplatin, Conventional Surgery - Stage III Vulvar Cancer, Stage IVB Vulvar Cancer | Phase 2 | Completed | Gynecologic Oncology Group | 61 | 2005-01-01 | 2017-11-20 |
| Collecting Tumor Samples From Patients With Gynecological Tumors Laboratory Biomarker Analysis - Borderline Ovarian Clear Cell Tumor, Borderline Ovarian Serous Tumor | Completed | Gynecologic Oncology Group | 275 | 1992-06-01 | 2016-10-28 |
Vulvar Neoplasms (8) · Uterine Cervical Neoplasms (3) · Vaginal Neoplasms (3) · Adenocarcinoma, Papillary (1) · Anus Neoplasms (1) · Brenner Tumor (1) · Carcinoma, Basal Cell (1) · Carcinoma, Basosquamous (1) · Carcinoma, Merkel Cell (1) · Carcinoma, Signet Ring Cell (1) · Eccrine Porocarcinoma (1) · Esophageal Squamous Cell Carcinoma (1) · Fallopian Tube Neoplasms (1) · Gestational Trophoblastic Disease (1) · Lymphoma, Large-Cell, Anaplastic (1)
Neoplasms (10) · Neoplasms by Site (10) · Female Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (9) · Urogenital Diseases (9) · Urogenital Neoplasms (9) · Genital Diseases (8) · Genital Diseases, Female (8) · Genital Neoplasms, Female (8) · Vulvar Diseases (8) · Neoplasms by Histologic Type (3) · Neoplasms, Glandular and Epithelial (3) · Uterine Cervical Diseases (3) · Uterine Diseases (3) · Uterine Neoplasms (3)
Cisplatin (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Nivolumab (2) · Platinum (2) · Watchful Waiting (2) · Biopsy (1) · Disulfides (1) · Gemcitabine (1) · Imiquimod (1) · Immunoglobulin G (1) · Radiosurgery (1) · Radiotherapy (1) · Radiotherapy, Conformal (1) · Radiotherapy, Intensity-Modulated (1) · Specimen Handling (1)
Gynecologic Oncology Group (4) · M.D. Anderson Cancer Center (2) · CCTU- Cancer Theme (1) · Canadian Cancer Trials Group (1) · Centre Leon Berard (1) · EvolveImmune United, Inc (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Latin American Cooperative Oncology Group (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1)
United States (10) · Canada (2) · Brazil (1) · France (1) · Italy (1) · New Zealand (1) · United Kingdom (1)
Amy Jamieson (1) · Angela Collarino, MD, PhD (1) · Brian Slomovitz (1) · David Moore (1) · Fernando Cotait Maluf (1) · Jessica McAlpine (1) · Kathleen Schmeler (1) · Kelly H. Bruce, MD, MS (1) · Li Tee Tan (1) · Lilie L Lin (1) · Michael Cibull (1) · Neil S Horowitz (1) · Oladapo Yeku, MD, PHD (1)
U10CA027469 (3), U10CA180868 (3), UM1CA186709 (1), UM1CA186716 (1)