15 terminated. 15 Phase 2, 5 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Terminated 15 |
| Phase 1 | 5 | Terminated 5 |
| Phase 3 | 2 | Terminated 2 |
Follow Uveitis: new trials by email Literature Review of Uveitis trials Research Report on Uveitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants REGN7041 - Active Noninfectious Uveitis Affecting the Posterior Segment | Phase 1 / Phase 2 | Terminated | Regeneron Pharmaceuticals | 1 | 2025-12-17 | 2026-08-17 |
| POC Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Active Intermediate, Posterior, or Pan NIU ESK-001 - Uveitis Posterior Non-Infectious, Uveitis, Intermediate | Phase 2 | Terminated | Alumis Inc | 36 | 2023-06-14 | 2024-08-28 |
| Phase 2b Pivotal Study of Izokibep in Non-infectious, Intermediate-, Posterior- or Pan-uveitis Izokibep, Placebo - Uveitis | Phase 2 | Terminated | ACELYRIN Inc. | 96 | 2022-08-23 | 2025-02-21 |
| A Study to Evaluate the Efficacy and Safety of Hemay005 in the Treatment of Behçet Disease Hemay005, Placebo - Behçet Disease | Phase 2 | Terminated | Tianjin Hemay Pharmaceutical Co., Ltd | 89 | 2020-11-30 | 2022-06-21 |
| Golimumab for the Treatment of Refractory Behcet's Uveitis Golimumab (GOL) - Behcet Syndrome, Uveitis | Phase 2 | Terminated | Wenjie Zheng | 1 | 2020-02-15 | 2023-04-07 |
| Effects of Conbercept in Refractory Uveitic Macular Edema and VEGF intravitreal injection of Conbercept - Uveitis, Macular Edema | Phase 2 / Phase 3 | Terminated | Peking Union Medical College Hospital | 5 | 2019-10-12 | 2022-10-25 |
| Tocilizumab for the Treatment of Refractory Behcet's Uveitis Tocilizumab (TCZ) - Behcet Syndrome, Uveitis | Phase 2 | Terminated | Wenjie Zheng | 3 | 2018-05-10 | 2021-03-22 |
| Intravitreal Adalimumab Versus Subcutaneous Adalimumab in Non-infectious Uveitis Adalimumab - Uveitis, Non-Infectious Uveitis | Phase 2 | Terminated | American University of Beirut Medical Center | 23 | 2016-02-01 | 2026-11-02 |
| Safety and Preliminary Efficacy Study of V404 PDS in Uveitis V404 - Uveitis, Posterior, Uveitis, Intermediate | Phase 1 / Phase 2 | Terminated | Forsight Vision4 | 7 | 2014-04-01 | 2016-12-09 |
| Tocilizumab for the Treatment of Behcet's Syndrome Tocilizumab - Behcet Syndrome | Phase 2 | Terminated | NYU Langone Health | 1 | 2012-09-01 | 2019-02-15 |
| Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate Methotrexate - Non-infectious Intermediate and Posterior Uveitis | Phase 1 / Phase 2 | Terminated | National Eye Institute (NEI) | 2 | 2011-02-01 | 2019-03-27 |
| Microplasmin Intravitreal Administration in Participants With Uveitic Macular Edema Microplasmin - Uveitis | Phase 1 / Phase 2 | Terminated | National Institutes of Health Clinical Center (CC) | 2 | 2011-01-01 | 2018-07-31 |
| Apremilast in the Treatment of Uveitis Apremilast - Uveitis | Phase 1 / Phase 2 | Terminated | Oregon Health and Science University | 3 | 2009-11-01 | 2014-07-08 |
| A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Dexamethasone - Anterior Uveitis | Phase 2 / Phase 3 | Terminated | Allergan | 5 | 2006-05-01 | 2011-05-30 |
| Study to Treat Uveitis Associated Macular Edema denufosol tetrasodium (INS37217) Intravitreal Injection - Cystoid Macular Edema, Uveitis | Phase 2 | Terminated | Merck Sharp & Dohme LLC | 15 | 2005-09-01 | 2016-11-29 |
Behcet Syndrome (4) · Macular Edema (4) · Uveitis, Intermediate (3) · Uveitis, Posterior (3) · Oral Ulcer (1) · Panuveitis (1) · Uveitis, Anterior (1)
Eye Diseases (15) · Uveal Diseases (15) · Panuveitis (8) · Cardiovascular Diseases (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Genetic Diseases, Inborn (4) · Hereditary Autoinflammatory Diseases (4) · Macular Degeneration (4) · Mouth Diseases (4) · Retinal Degeneration (4) · Retinal Diseases (4) · Skin Diseases (4) · Skin Diseases, Genetic (4) · Skin Diseases, Vascular (4)
Methotrexate (2) · tocilizumab (2) · Adalimumab (1) · Cyclic Nucleotide Phosphodiesterases, Type 4 (1) · Dexamethasone (1) · Hemay005 (1) · Intravitreal Injections (1) · apremilast (1) · denufosol tetrasodium (1) · golimumab (1) · microplasmin (1)
Wenjie Zheng (2) · ACELYRIN Inc. (1) · Allergan (1) · Alumis Inc (1) · American University of Beirut Medical Center (1) · Forsight Vision4 (1) · Merck Sharp & Dohme LLC (1) · NYU Langone Health (1) · National Eye Institute (NEI) (1) · National Institutes of Health Clinical Center (CC) (1) · Oregon Health and Science University (1) · Peking Union Medical College Hospital (1) · Regeneron Pharmaceuticals (1) · Tianjin Hemay Pharmaceutical Co., Ltd (1)
United States (9) · China (4) · Austria (1) · Czechia (1) · France (1) · Germany (1) · Italy (1) · Lebanon (1) · Spain (1)
Wenjie Zheng, M.D. (2) · Amy Schaberg, BSN (1) · Donald Betah (1) · Eric B Suhler, MD, MPH (1) · Hatice N Sen, M.D. (1) · Hatice Nida Sen, MD, MHSc (1) · Rola N Hamam, MD (1) · Yusuf Yazici, MD (1)
PMID 28528519, PMID 29471416, PMID 41748391
2025 (1)