Hereditary Autoinflammatory Diseases: Clinical Trials

103 completed, 43 unknown, 40 recruiting, 21 not yet recruiting. 49 Phase 2, 42 Not applicable, 26 Phase 3, 14 Phase 1, 6 Phase 4.

By phase and status

Phase	Trials	Status
Phase 2	49	Completed 26, Terminated 7, Recruiting 5, Unknown 5, Withdrawn 4, Active not recruiting 1, Not yet recruiting 1
Not applicable	42	Unknown 15, Completed 11, Recruiting 11, Not yet recruiting 2, Enrolling by invitation 1, Terminated 1, Withdrawn 1
Phase 3	26	Completed 17, Recruiting 5, Not yet recruiting 2, Terminated 2
Phase 1	14	Completed 7, Recruiting 2, Terminated 2, Enrolling by invitation 1, Unknown 1, Withdrawn 1
Phase 4	6	Completed 2, Unknown 2, Active not recruiting 1, Withdrawn 1
Early Phase 1	1	Completed 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Goflikicept for Resolution and Prevention of Attacks in Pediatric and Adolescent Patients With Colchicine-Resistant or Colchicine-Intolerant Familial Mediterranean Fever RPH-104 - Familial Mediterranean Fever, FMF	Phase 3	Not yet recruiting	R-Pharm	18	2026-12-01	2026-10-19
Gryrotonic Training in Behcet-diseased Elders With Breast Cancer exercise - Breast Cancer, Behcet Disease	Not applicable	Recruiting	Cairo University	40	2026-11-30	2026-11-10
Clinical, Laboratory, and Therapeutic Analysis of Behçet's Disease in Assiut Behçet's Disease		Not yet recruiting	Assiut University	30	2026-09-30	2025-09-05
Genotype and Phenotype in Pediatric Familial Mediterranean Fever Familial Mediterranean Fever		Not yet recruiting	Assiut University	84	2026-09-26	2026-10-05
Serum EBI-3 Protein Levels in Behçet's Disease Behçet Disease		Not yet recruiting	Assiut University	90	2026-09-26	2026-09-28
Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research Pericarditis, Tako-TSUBO Cardiomyopathy		Not yet recruiting	Assistance Publique - Hôpitaux de Paris	300	2026-09-01	2026-08-10
Corticotropin for Behçet's Disease: A Multicenter Randomized Controlled TrialAcronym. Repository Corticotropin Injection (ACTH), Study-matched inactive placebo injection, also called control injection - Behçet's Syndrome, Behçet's Syndrome (BS)	Phase 2	Not yet recruiting	Peking University People's Hospital	60	2026-09-01	2026-09-22
Asprosin in Behect Patients Behcet Disease		Not yet recruiting	Assiut University	44	2026-09-01	2026-09-03
Metabolic Syndrome Resposne to Dietary Limitations in Familial Mediterranean Fever in Adolescents low calorie diet - Familial Mediterranean Fever (FMF ), Metabolic Syndrome	Not applicable	Recruiting	Cairo University	40	2026-08-10	2026-09-22
Validity and Reliability of the International Physical Fitness Questionnaire and the Self-Perceived Health-Related Physical Fitness Questionnaire in Children and Adolescents With JIA and FMF Juvenile Idiopathic Arthritis, Familial Mediterranean Fever		Not yet recruiting	Istanbul University - Cerrahpasa	100	2026-07-01	2026-06-01
Diet Restiction in Subjects With Behcet Disease and Complaint of Tinnitus diet restriction - Behcet Disease, Obesity	Not applicable	Recruiting	Cairo University	40	2026-06-04	2026-07-14
Efficacy of Physical Activity Program in Metabolic-syndrome Females With Behcet Disease treadmill walking - Metabolic Syndrome, Behcet Disease	Not applicable	Recruiting	Cairo University	40	2026-06-02	2026-07-14
Ivarmacitinib for Refractory Behcet's Syndrome Ivarmacitinib - Behcet's Syndrome	Phase 2	Withdrawn	Liu Tian		2026-06-01	2026-07-10
Behcet Disease Patients With Pulmonary Endoarterectomy: Outcomes of Program of Inspiratory Msucle Trianing inspiratory muscle trianing - Behcet Disease	Not applicable	Recruiting	Cairo University	40	2026-05-06	2026-06-23
Efficacy and Safety of Thalidomide for Pediatric PFAPA Syndrome Thalidomide (50mg), Colchicine - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome	Not applicable	Not yet recruiting	Wenjie Zheng	106	2026-04-01	2026-03-17
A Study on the Use of Canakinumab Among Familial Mediterranean Fever and Still's Disease Patients Familial Mediterranean Fever, Still Disease		Recruiting	Novartis Pharmaceuticals	160	2026-03-15	2026-06-09
A Study to Evaluate Efficacy and Safety of Anakinra in Chinese Patients With Colchicine-resistent FMF Anakinra - Familial Mediterranean Fever (FMF )	Phase 4	Withdrawn	Swedish Orphan Biovitrum		2026-03-01	2026-06-29
Circadian Rhythm Deregulation in Patients With CAPS Genetic analysis of NLRP3, Circadian rhythm measurement, Saliva sampling - Cryopyrin Associated Periodic Syndrome, Familial Cold Urticaria	Not applicable	Recruiting	Hospices Civils de Lyon	30	2026-02-25	2026-02-27
Study to Evaluate the Safety, Tolerability, Efficacy and Pharmacokinetics of JTE-162 in Subjects With Cryopyrin-Associated Periodic Syndrome (CAPS) JTE-162 - Cryopyrin-associated Periodic Syndromes (CAPS)	Phase 1	Completed	Akros Pharma Inc.	5	2026-02-02	2026-10-09
AGE and CALLY Index in Familial Mediterranean Fever Skin Autofluorescence Measurement - Familial Mediterranean Fever		Not yet recruiting	Bursa City Hospital	150	2026-02-01	2026-02-27

Showing 20 of 237. Sign in to see all of them.

Narrower conditions

Behcet Syndrome (132)  ·  Familial Mediterranean Fever (60)  ·  Cryopyrin-Associated Periodic Syndromes (35)  ·  Uveitis (17)  ·  Arthritis, Juvenile (14)  ·  Takayasu Arteritis (12)  ·  Arthritis, Rheumatoid (10)  ·  Giant Cell Arteritis (9)  ·  Granulomatosis with Polyangiitis (8)  ·  Retinal Vasculitis (8)  ·  Sarcoidosis (8)  ·  Lupus Erythematosus, Systemic (7)  ·  Microscopic Polyangiitis (7)  ·  Polyarteritis Nodosa (7)

Broader conditions

Congenital, Hereditary, and Neonatal Diseases and Abnormalities (237)  ·  Genetic Diseases, Inborn (234)  ·  Skin and Connective Tissue Diseases (184)  ·  Skin Diseases (179)  ·  Skin Diseases, Genetic (176)  ·  Skin Diseases, Vascular (166)  ·  Mouth Diseases (135)  ·  Stomatognathic Diseases (135)  ·  Eye Diseases (134)  ·  Vascular Diseases (132)  ·  Cardiovascular Diseases (131)  ·  Uveal Diseases (131)  ·  Uveitis, Anterior (131)  ·  Panuveitis (129)

Interventions

canakinumab (14)  ·  Interleukin 1 Receptor Antagonist Protein (8)  ·  Blood Specimen Collection (4)  ·  Colchicine (4)  ·  apremilast (4)  ·  rilonacept (4)  ·  tocilizumab (4)  ·  Cyclophosphamide (3)  ·  Quality of Life (3)  ·  4-amino-4'-hydroxylaminodiphenylsulfone (2)  ·  Adrenal Cortex Hormones (2)  ·  Butyrates (2)  ·  Cyclic Nucleotide Phosphodiesterases, Type 4 (2)  ·  Cyclosporine (2)  ·  Diet, Vegetarian (2)

Sponsors

Assiut University (19)  ·  Novartis Pharmaceuticals (17)  ·  Assistance Publique - Hôpitaux de Paris (12)  ·  Cairo University (11)  ·  Istanbul University - Cerrahpasa (8)  ·  Tehran University of Medical Sciences (6)  ·  Istanbul University (5)  ·  Peking Union Medical College Hospital (5)  ·  Sheba Medical Center (5)  ·  University of South Florida (5)  ·  Amgen (4)  ·  Marmara University (4)  ·  National Eye Institute (NEI) (4)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (4)  ·  National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (4)

Countries

Turkey (Türkiye) (50)  ·  United States (48)  ·  France (34)  ·  Egypt (23)  ·  China (19)  ·  Germany (17)  ·  Italy (17)  ·  Spain (14)  ·  Israel (13)  ·  United Kingdom (10)  ·  Iran (8)  ·  Canada (7)  ·  Greece (7)  ·  South Korea (7)  ·  Switzerland (7)

Top investigators

Ali MA Ismail, lecturer (6)  ·  Fereydoun Davatchi, MD (4)  ·  Peter A. Merkel, MD, MPH (4)  ·  Amanda M. Terry, MA (3)  ·  Avi Livneh, MD (3)  ·  Bahar Sadeghi, MD (3)  ·  Mikhail Samsonov (3)  ·  Farhad Shahram, MD (2)  ·  Farhad Shahram, Professor (2)  ·  Hormoz Shams, MD (2)  ·  Megan Clowse, MD, MPH (2)  ·  Peter A Merkel, MD, MPH (2)  ·  Peter C. Grayson, MD (2)

Results publications

PMID 24533607, PMID 31161734, PMID 37316690, PMID 11459787, PMID 13769243, PMID 15161982, PMID 16899778, PMID 16998234, PMID 17554116, PMID 17960403, PMID 18668535, PMID 18668591, PMID 19026127, PMID 19494217, PMID 19597921, PMID 1970380, PMID 19717547, PMID 20704622, PMID 20926833, PMID 21356079, PMID 21482866, PMID 21859692, PMID 22152723, PMID 22168993, PMID 22234484, PMID 22294344, PMID 22583335, PMID 22825366, PMID 23031624, PMID 23070486, PMID 23290985, PMID 23380020, PMID 23773637, PMID 24169272, PMID 24275240, PMID 24467729, PMID 24488418, PMID 24833067, PMID 24906637, PMID 25147819, PMID 25223501, PMID 25369738, PMID 25638011, PMID 25875256, PMID 26026392, PMID 26337145, PMID 26823530, PMID 26879979, PMID 27055417, PMID 27143789

NIH funding

2009 (2), 2014 (2), 2023 (2), R21EY036563 (1), ZIAAR041138-08 (1)