1 active not recruiting, 1 not yet recruiting. 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Active not recruiting 1, Not yet recruiting 1 |
Follow TP53 Gene Mutation: new trials by email Literature Review of TP53 Gene Mutation trials Research Report on TP53 Gene Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Axatilimab Combined With Decitabine/Venetoclax for the Treatment of TP53-mutated AML Decitabine, Venetoclax, Axatilimab - Acute Myeloid Leukemia, TP53 Gene Mutation | Phase 1 | Not yet recruiting | Northside Hospital, Inc. | 32 | 2027-01-31 | 2026-10-16 |
| Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy Laboratory Biomarker Analysis, Modified Vaccinia Virus Ankara Vaccine Expressing p53, Pembrolizumab - Adult Solid Neoplasm, Bladder Carcinoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 11 | 2015-12-28 | 2026-10-19 |
Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Renal Cell (1) · Colonic Neoplasms (1) · Leukemia, Myeloid, Acute (1) · Melanoma (1) · Pancreatic Neoplasms (1) · Rectal Neoplasms (1) · Sarcoma (1) · Squamous Cell Carcinoma of Head and Neck (1) · Triple Negative Breast Neoplasms (1) · Urinary Bladder Neoplasms (1)
Neoplasms (2) · Neoplasms by Histologic Type (2) · Adenocarcinoma (1) · Breast Diseases (1) · Breast Neoplasms (1) · Bronchial Neoplasms (1) · Carcinoma (1) · Carcinoma, Bronchogenic (1) · Carcinoma, Squamous Cell (1) · Colonic Diseases (1) · Colorectal Neoplasms (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Endocrine Gland Neoplasms (1) · Endocrine System Diseases (1)
Decitabine (1) · MVAp53 vaccine (1) · axatilimab (1) · pembrolizumab (1) · venetoclax (1)
City of Hope Medical Center (1) · Northside Hospital, Inc. (1)
United States (2)
Vincent Chung (1)
PMID 20602996, PMID 20876310, PMID 21654748, PMID 23733335, PMID 24639350, PMID 25047706, PMID 25157821, PMID 25484881, PMID 26358057, PMID 28126925, PMID 28212753, PMID 29632729, PMID 30425048, PMID 31940491, PMID 32002295, PMID 32499238, PMID 32605996, PMID 32730593, PMID 33057635, PMID 33415170, PMID 34249942, PMID 34255353, PMID 34298810, PMID 34771453, PMID 35030341, PMID 35965420, PMID 36226545, PMID 36459673, PMID 36549780, PMID 37370821, PMID 39133921, PMID 39292927, PMID 39457618, PMID 7506935