9 terminated. 9 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Terminated 9 |
| Phase 1 | 1 | Terminated 1 |
Follow Thymoma: new trials by email Literature Review of Thymoma trials Research Report on Thymoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of KN046 in Patients With Thymic Carcinoma Who Failed Immune Checkpoint Inhibitors KN046 - Thymic Carcinoma | Phase 2 | Terminated | Weill Medical College of Cornell University | 4 | 2021-12-13 | 2024-04-16 |
| KN046 (a Humanized PD-L1/CTLA4 Bispecific Single Domain Fc Fusion Protein Antibody) in Subjects With Thymic Carcinoma KN046 - Thymic Carcinoma | Phase 2 | Terminated | Jiangsu Alphamab Biopharmaceuticals Co., Ltd | 95 | 2020-12-02 | 2024-03-12 |
| Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy Open Label Selinexor - Thymoma, Advanced Thymic Epithelial Tumor | Phase 2 | Terminated | Georgetown University | 8 | 2018-04-03 | 2023-02-16 |
| Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy Doxepin Hydrochloride, Placebo, Quality-of-Life Assessment - Esophageal Carcinoma, Hypopharyngeal Carcinoma | Phase 2 | Terminated | Mayo Clinic | 5 | 2014-04-14 | 2019-10-01 |
| Study Of Oral PHA-848125AC In Patients With Malignant Thymoma Previously Treated With Multiple Lines Of Chemotherapy Milciclib Maleate - Malignant Thymoma | Phase 2 | Terminated | Tiziana Life Sciences LTD | 30 | 2011-02-02 | 2019-02-06 |
| A Phase 1/2 Study of PXD101 (Belinostat) in Combination With Cisplatin, Doxorubicin and Cyclophosphamide in the First Line Treatment of Advanced or Recurrent Thymic, Malignancies PXD101with cisplatin+doxorubicin+cyclophosphamide - Thymoma, Thymic Carcinoma | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 26 | 2010-03-04 | 2017-08-10 |
| Phase II Study Of Oral PHA-848125AC In Patients With Thymic Carcinoma Milciclib Maleate - Thymic Carcinoma | Phase 2 | Terminated | Tiziana Life Sciences LTD | 72 | 2010-02-22 | 2019-02-06 |
| Paclitaxel and Cisplatin for Thymic Neoplasm paclitaxel and cisplatin - Thymoma, Thymic Carcinoma | Phase 2 | Terminated | Korean Cancer Study Group | 39 | 2008-09-01 | 2013-04-12 |
| Saracatinib in Treating Patients With Relapsed or Refractory Thymoma or Thymic Cancer saracatinib - Invasive Thymoma and Thymic Carcinoma, Recurrent Thymoma and Thymic Carcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 21 | 2008-06-01 | 2015-06-10 |
Carcinoma, Non-Small-Cell Lung (1) · Esophageal Neoplasms (1) · Hypopharyngeal Neoplasms (1) · Laryngeal Neoplasms (1) · Lymphoma (1) · Mesothelioma (1) · Sarcoma (1) · Small Cell Lung Carcinoma (1) · Thymic epithelial tumor (1) · Thymus Neoplasms (1) · Thyroid Neoplasms (1)
Hemic and Lymphatic Diseases (9) · Lymphatic Diseases (9) · Neoplasms (9) · Neoplasms by Histologic Type (9) · Neoplasms by Site (9) · Neoplasms, Complex and Mixed (9) · Thoracic Neoplasms (9) · Thymus Neoplasms (8) · Adenoma (1) · Bronchial Neoplasms (1) · Carcinoma, Bronchogenic (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Endocrine Gland Neoplasms (1) · Endocrine System Diseases (1)
N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide (2) · Doxepin (1) · TP protocol (1) · saracatinib (1) · selinexor (1)
National Cancer Institute (NCI) (2) · Tiziana Life Sciences LTD (2) · Georgetown University (1) · Jiangsu Alphamab Biopharmaceuticals Co., Ltd (1) · Korean Cancer Study Group (1) · Mayo Clinic (1) · Weill Medical College of Cornell University (1)
United States (7) · Italy (2) · China (1) · France (1) · South Korea (1)
Arun Rajan, MD. (2) · Arun Rajan, M.D. (1) · Barbara Ma, MD (1) · Benjamin Besse, MD (1) · Chul Kim, MD (1) · Dae Seog Heo, MD, PhD (1) · Giuseppe Giaccone, MD (1) · Glen Weiss, MD (1) · Marina C Garassino, MD (1) · Marina C. Garassino, MD. (1) · Patrick Loehrer (1) · Silvia Novello, MD (1) · Terence Sio (1) · Xiaolong Fu, MD (1)
PMID 21502553, PMID 25189481, PMID 26009269, PMID 34393061
2009 (1), P30CA015083 (1)