14 unknown, 9 recruiting, 8 completed, 5 terminated. 22 Phase 2, 18 Phase 3, 4 Not applicable, 1 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Umbrella-designed Prospective Multicenter Randomized Open-label Superiority Trial Evaluating Multi-biomarker-guided Precision Therapy for First-line Treatment of Advanced Esophageal Squamous Cell Carcinoma Paclitaxel + Cisplatin (TP regimen) plus PD-1 inhibitor, Retlirafusp alfa / Indole-3-carbinol + Black garlic fermentation extract / Lactobacillus rhamnosus / Placebo + Paclitaxel + Cisplatin (TP regimen) plus PD-1 inhibitor - Valid MeSH Conditions | Phase 2 | Not yet recruiting | Sun Yat-sen University | 347 | 2026-07-07 | 2026-07-16 |
| SYS6010 Combined With Enlonstobart Versus Immunotherapy+ Platinum-based Chemotherapy for Patients With PD-L1-Positive Locally Advanced or Metastatic NSCLC（SYNSTAR 04） SYS6010 injection, Enlonstobart injection, Tislelizumab injection - Non-Small Cell Lung Cancer | Phase 3 | Not yet recruiting | CSPC Megalith Biopharmaceutical Co.,Ltd. | 500 | 2026-06-02 | 2026-06-11 |
| CCRT Followed by PD-1 Inhibitor Maintenance Therapy in Locally Advanced ESCC PD-1 inhibitor, Unlimited radiotherapy, TP regimen - Esophageal Carcinoma, Radiotherapy | Phase 3 | Recruiting | Fudan University | 452 | 2025-02-01 | 2026-04-17 |
| Efficacy of Organoid-Based Chemotherapy Drug Precision Screening to Guide Treatment for Thyroid Cancer Cyclophosphamide+Pemetrexed+5-Fluorouracil, Cyclophosphamide+Doxorubicin+5-Fluorouracil, Vindesine + Cisplatin - Locally Advanced Thyroid Gland Carcinoma, Thyroid Cancer | Phase 2 | Not yet recruiting | West China Hospital | 20 | 2024-12-01 | 2024-12-03 |
| A Multi-cohort Study of Efbemalenograstim Alfa Injection for Preventing ANC Reduction in Solid Tumor Patients Post Immune-chemotherapy. Efbemalenograstim alfa Injection, carboplatin/cisplatin-etoposide, Carboplatin plus Paclitaxel - Solid Tumor Cancer, Chemotherapy Induced Neutropenia | Not applicable | Not yet recruiting | Shandong Cancer Hospital and Institute | 200 | 2024-10-10 | 2024-10-18 |
| BTLA Inhibitor (JS004) Combined with Toripalimab and Chemotherapy in the Perioperative Treatment of Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma BTLA inhibitor (JS004), Toripalimab, Paclitaxel, Cisplatin - Esophageal Squamous Cell Carcinoma | Phase 2 | Unknown | Henan Provincial People's Hospital | 20 | 2024-09-30 | 2024-09-19 |
| Biomarker Based Neoadjuvant Strategies for Locally Advanced Resectable ESCC Serplulimab, Paclitaxel+Cisplatin (Neoadjuvant Chemotherapy), Paclitaxel+Cisplatin(Concurrent Chemoradiotherapy) - Esophageal Squamous Cell Carcinoma | Phase 2 | Recruiting | Fujian Medical University Union Hospital | 90 | 2024-07-11 | 2026-10-29 |
| Cadonilimab With Chemoradiation for Recurrent and Oligometastatic Endometrial Carcinoma Paclitaxel and Cisplatin, Cadonilimab, Radiotherapy - Endometrial Neoplasms, Neoplasm Recurrence, Local | Phase 2 | Recruiting | Shandong Cancer Hospital and Institute | 30 | 2024-06-13 | 2026-04-24 |
| Combination of Cadonilimab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-006) Cadonilimab, Paclitaxel and cisplatin, intensity-modulated radiotherapy - Esophagus Cancer | Phase 2 | Active not recruiting | Sun Yat-sen University | 46 | 2024-03-02 | 2026-04-23 |
| Sintilimab and Chemotherapy Sequential Radiotherapy in Advanced Esophageal Cancer TP regimen (cis-platinum ; Tocetaxel ) combined with PD-1 inhibitors（Sintilimab） - Metastatic Esophageal Squamous Cell Carcinoma | Phase 2 / Phase 3 | Recruiting | Qingdao Central Hospital | 90 | 2023-09-20 | 2024-07-24 |
| Single-Arm Exploratory Study of PD-L1 Antibody Plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma Adebrelimab, TP regimen, Surgery or radiotherapy - Squamous Cell Carcinoma of Head and Neck | Phase 2 | Recruiting | Xiuping Ding | 69 | 2023-04-01 | 2025-07-09 |
| Combination of Tislelizumab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-002) Paclitaxel, Cisplatin, tislelizumab, Radiotherapy - Esophageal Squamous Cell Carcinoma, Locally Advanced Esophageal Squamous Cell Carcinoma | Phase 2 | Active not recruiting | Sun Yat-sen University | 114 | 2022-09-15 | 2024-11-18 |
| Neoadjuvant Immunotherapy to ESCC Sintilimab Injection plus Paclitaxel and Cisplatin, Paclitaxel and Cisplatin - Esophagus SCC | Phase 2 | Withdrawn | Qilu Hospital of Shandong University | 2020-12-01 | 2022-04-26 | |
| Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer Neoadjuvant radiotherapy (arm A), Carboplatin, paclitaxel, Esophagectomy - Esophageal Squamous Cell Carcinoma | Phase 3 | Recruiting | Karolinska University Hospital | 1020 | 2020-11-27 | 2025-03-06 |
| AT Versus TP as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer AT regimen, TP regimen - HER2-negative Breast Cancer | Phase 2 | Unknown | Sichuan Provincial People's Hospital | 100 | 2020-08-01 | 2020-08-05 |
| The Efficacy of Adjuvant Chemotherapy in Locally Advanced Cervical Cancer CCRT, Paclitaxel, Cisplatin - Cervical Cancer | Not applicable | Recruiting | Chongqing University Cancer Hospital | 120 | 2020-05-26 | 2023-04-11 |
| Neoadjuvant Chemotherapy Versus Neoadjuvant Chemoradiotherapy for Resectable Locally Advanced Esophageal Cancer (HCHTOG1903) Paclitaxel, Cisplatin, neoadjuvant chemoradiation therapy - Esophageal Squamous Cell Carcinoma | Phase 3 | Recruiting | Henan Cancer Hospital | 456 | 2019-10-22 | 2022-08-09 |
| Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer Toripalimab, Paclitaxel/Cisplatin, Intensity-modulated radiotherapy - Unresectable Esophageal Cancer | Phase 2 | Completed | Mian XI | 42 | 2019-06-25 | 2022-08-23 |
| Combination of Toripalimab and Neoadjuvant Chemoradiotherapy in Esophageal Cancer Toripalimab, Paclitaxel/cisplatin, Intensity-modulated radiotherapy - Esophageal Squamous Cell Carcinoma by AJCC V8 Stage, Resectable Esophageal Cancer | Phase 2 | Unknown | Jianhua Fu | 44 | 2019-06-25 | 2019-12-26 |
| KN046 in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma KN046, palliative radiotherapy - Esophageal Squamous Cell Carcinoma | Phase 2 | Unknown | Shanghai Chest Hospital | 100 | 2019-05-22 | 2019-05-29 |
Showing 20 of 43. Sign in to see all of them.
Esophageal Squamous Cell Carcinoma (13) · Esophageal Neoplasms (9) · Carcinoma, Non-Small-Cell Lung (5) · Uterine Cervical Neoplasms (4) · Lymphatic Metastasis (2) · Neoplasm Metastasis (2) · Squamous Cell Carcinoma of Head and Neck (2) · Breast Neoplasms (1) · Carcinoma, Ductal, Breast (1) · Carcinoma, Squamous Cell (1) · Endometrial Neoplasms (1) · Fallopian Tube Neoplasms (1) · Head and Neck Neoplasms (1) · Lung Neoplasms (1) · Melanoma (1)
Sun Yat-sen University (4) · Chinese Academy of Medical Sciences (3) · Fudan University (3) · Chongqing University Cancer Hospital (2) · Henan Cancer Hospital (2) · Shandong Cancer Hospital and Institute (2) · Shanghai Chest Hospital (2) · CSPC Megalith Biopharmaceutical Co.,Ltd. (1) · Cadila Pharnmaceuticals (1) · Fujian Medical University Union Hospital (1) · Henan Provincial People's Hospital (1) · Indira Gandhi Medical College, Shimla (1) · Institut fuer Frauengesundheit (1) · Jianhua Fu (1) · Jinling Hospital, China (1)
China (30) · Germany (3) · India (2) · Taiwan (2) · Canada (1) · Ireland (1) · Norway (1) · South Korea (1) · Sweden (1) · United Kingdom (1) · United States (1)
A. Rajkumar, MD (1) · A.K. Patel, MD (1) · Aloke G Dastidar, MD (1) · Anup Majumdar, MD (1) · Apurva Patel, MD (1) · Ashutosh N Aggarwal, MD (1) · Chanchal Goswami, MD (1) · Chao Zhou, MD. (1) · Dae Seog Heo, MD, PhD (1) · Daliang Qi, Master (1) · Dongling Zou, M.D. (1) · Falk Thiel, Dr. med. (1) · Florian Lordick, MD, PhD (1) · Haihua Yang, MD. (1) · J Y Chang, M.D. (1)
PMID 36990609, PMID 14673047, PMID 17928611, PMID 20421764, PMID 20626450, PMID 20700125, PMID 25164541, PMID 26530541, PMID 26904570, PMID 28317872, PMID 30344165, PMID 30642373, PMID 32044419, PMID 32293362, PMID 32789480, PMID 34454674, PMID 34519801, PMID 35108470, PMID 35188552, PMID 35912196, PMID 37560259, PMID 37797632, PMID 37852261, PMID 38490057, PMID 39235488, PMID 39281099, PMID 41962116
2005 (1)