28 completed, 13 unknown, 4 active not recruiting, 2 recruiting. 12 Not applicable, 10 Phase 2, 8 Phase 4, 5 Phase 1, 4 Phase 3.
Follow Thalassemia Major: new trials by email Literature Review of Thalassemia Major trials Research Report on Thalassemia Major
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Incentive Respiratory Training on Pulmonary Functions and Functional Capacity in Children With B-thalassemia Major Incentive spirometer exercises, Diaphragmatic breathing, Pursed lip breathing: - Incentive Spirometer, Pulmonary Function | Not applicable | Recruiting | Rawan Mohammed Khairy Mostafa Elsawy | 50 | 2025-04-07 | 2025-08-08 |
| Growth Evaluation, Health Promotion, and Clinical Management in Children and Adolescents With Thalassemia MENBS clinical interventions - Thalassemia Intermedia, Thalassemia Major | Not applicable | Active not recruiting | Institute of Hematology & Blood Diseases Hospital, China | 385 | 2024-12-01 | 2026-09-18 |
| Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia Thalidomide - Fetal Hemoglobin, Thalassemia Major | Phase 2 | Recruiting | National Institute of Blood and Marrow Transplant (NIBMT), Pakistan | 54 | 2024-04-22 | 2025-05-30 |
| NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major n-acetylcystine - Thalassemia Major | Phase 1 | Unknown | Assiut University | 100 | 2024-03-23 | 2023-08-23 |
| Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem Cells γ-globin reactivated autologous hematopoietic stem cells - Thalassemia Major | Not applicable | Suspended | Bioray Laboratories | 5 | 2023-12-25 | 2024-02-28 |
| Longitudinal Study on the QoL of Pediatric Patients After HSCT and Its Influencing Factors Conventional nursing - Thalassemia Major, Acute Leukemia | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 250 | 2023-10-30 | 2023-10-23 | |
| Safety and Efficacy Evaluation of Autologous CRISPR-Cas12b Edited Hematopoietic Stem Cells VGB-Ex01 - Thalassemia, Beta, Thalassemia Major | Not applicable | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 2 | 2023-08-31 | 2023-10-17 |
| Study to Evaluate the Long- Term Safety and Efficacy of Luspatercept in Subjects Who Received at Least One Dose of Luspatercept in the Compassionate Use Phase Luspatercept (ACE-536) - Thalassemia Major | Active not recruiting | Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia | 140 | 2023-05-30 | 2025-04-06 | |
| To Evaluate Long- Term Safety and Efficacy of Luspatercept Luspatercept (ACE-536) - Thalassemia Major | Active not recruiting | Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia | 350 | 2023-04-30 | 2025-03-13 | |
| Study on the Effect of Different Risk Factors on the Growth Parameters of Thalassemic Patients in Assiut (AUCH) serum ferritin and AST - Thalassemia Major | Unknown | Assiut University | 50 | 2022-07-02 | 2022-03-31 | |
| The Safety and Efficiency of Luspatercept in Chinese Adults With Transfusion Dependent β-thalassemia: a Real-world Study Luspatercept Injectable Product - Thalassemia Major, Transfusion-dependent Anemia | Phase 4 | Unknown | Sun Yat-sen University | 20 | 2022-07-01 | 2022-07-18 |
| EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT) EDIT-301 - Transfusion Dependent Beta Thalassemia, Hemoglobinopathies | Phase 1 / Phase 2 | Active not recruiting | Editas Medicine, Inc. | 9 | 2022-04-29 | 2025-04-02 |
| Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological Diseases SARS-CoV-2 S1/S2 IgG - Thalassemia Major, Covid19 | Completed | University of Milano Bicocca | 63 | 2020-07-14 | 2020-11-09 | |
| Thalassemic Iron Overload Cardiomyopathy is Ameliorated by Taurine Supplementation Taurine, Placebo - Thalassemia Major | Not applicable | Unknown | University Health Network, Toronto | 60 | 2020-06-01 | 2023-10-03 |
| Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies CliniMACS - Sickle Cell Disease, Thalassemia Major | Not applicable | Completed | Timothy Olson | 8 | 2020-05-14 | 2026-04-28 |
| Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia Omega 3, Nigella Sativa Oil, Hydroxyurea - Iron Overload, Oxidative Stress | Phase 2 / Phase 3 | Completed | Beni-Suef University | 350 | 2019-11-01 | 2021-01-27 |
| Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation DST-0509, Jadenu, Exjade - Thalassemia Major | Phase 2 | Completed | DisperSol Technologies, LLC | 25 | 2019-08-20 | 2022-02-01 |
| Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study Busulfan, Cyclophosphamide, Fludarabine - Thalassemia Major | Phase 4 | Completed | First Affiliated Hospital of Guangxi Medical University | 823 | 2019-07-05 | 2024-08-09 |
| The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major N-acetyl cysteine - Thalassemia Major | Phase 1 | Completed | Beni-Suef University | 100 | 2019-06-03 | 2020-02-07 |
| Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia Major Thalassemia Major | Unknown | National Taiwan University Hospital | 100 | 2019-04-01 | 2021-02-18 |
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beta-Thalassemia (50) · Thalassemia (12) · Anemia, Sickle Cell (6) · Iron Overload (5) · Genetic Diseases, Inborn (4) · Anemia, Aplastic (3) · Anemia, Diamond-Blackfan (3) · Hematologic Diseases (3) · Hemoglobinopathies (3) · Osteoporosis (3) · Rare Diseases (3) · Bone Diseases, Metabolic (2) · Fanconi Anemia (2) · Hemochromatosis (2) · Red-Cell Aplasia, Pure (2)
Anemia (50) · Anemia, Hemolytic (50) · Anemia, Hemolytic, Congenital (50) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (50) · Hemic and Lymphatic Diseases (50) · Hematologic Diseases (47) · Hemoglobinopathies (47) · Genetic Diseases, Inborn (46) · Thalassemia (38) · Metabolic Diseases (11) · Nutritional and Metabolic Diseases (11) · Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (6) · Disease Attributes (5) · Iron Metabolism Disorders (5)
Busulfan (4) · Deferoxamine (4) · Cyclophosphamide (3) · Deferiprone (3) · Tacrolimus (3) · fludarabine (3) · luspatercept (3) · Deferasirox (2) · Influenza Vaccines (2) · Isoflurophate (2) · Methotrexate (2) · Mycophenolic Acid (2) · thymoglobulin (2) · 6-amino-1-hydroxyhexane-1,1-diphosphonate (1) · Abatacept (1)
Assiut University (3) · Beni-Suef University (2) · Ente Ospedaliero Ospedali Galliera (2) · First Affiliated Hospital of Guangxi Medical University (2) · Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia (2) · Institute of Hematology & Blood Diseases Hospital, China (2) · National Center for Research Resources (NCRR) (2) · University Health Network, Toronto (2) · University of Milano Bicocca (2) · Ain Shams University (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · ApoPharma (1) · Azienda Ospedaliera V. Cervello (1) · Azienda Ospedaliero-Universitaria di Modena (1) · Bioray Laboratories (1)
United States (14) · Italy (12) · China (8) · Egypt (5) · Canada (3) · Greece (3) · Thailand (2) · Turkey (Türkiye) (2) · Brazil (1) · Iran (1) · Lebanon (1) · Pakistan (1) · Saudi Arabia (1) · Singapore (1) · Taiwan (1)
Yongrong Lai, MD (2) · Ahmed F Mahmoud Hussein, MS.c (1) · Alan Richard Cohen (1) · Andrea Biondi, MD, PhD (1) · Antonio Piga, M.D. (1) · Antonio Piga, MD (1) · Barbara B Biesecker (1) · Catherine J. Wu, MD (1) · Catherine Wu, MD (1) · Deborah Chirnomas, MD (1) · Ernesto Palummeri, MD (1) · Ersi Voskaridou, Doctor (1) · Gary M. Brittenham, M.D. (1)
PMID 37975597, PMID 14550808, PMID 19236376, PMID 19724055, PMID 22571408, PMID 24081970, PMID 25222041, PMID 26653680, PMID 27862048, PMID 30381400, PMID 31907538, PMID 32311145, PMID 32314798, PMID 32330288, PMID 32394480, PMID 32395210, PMID 39891377, PMID 41730859, PMID 41931048, PMID 41984996
2014 (1)