36 completed, 6 unknown, 4 terminated, 3 active not recruiting. 14 Phase 2, 9 Not applicable, 6 Phase 3, 4 Phase 1, 2 Phase 4.
Follow Hemochromatosis: new trials by email Literature Review of Hemochromatosis trials Research Report on Hemochromatosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate BBI-001 in Healthy Volunteers and in Patients With Hereditary Hemochromatosis BBI-001, Placebo - Hereditary Hemochromatosis | Phase 1 / Phase 2 | Recruiting | Bond Biosciences | 34 | 2026-05-04 | 2026-05-13 |
| Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis Vamifeport, Placebo - Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis | Phase 2 | Active not recruiting | CSL Behring | 84 | 2026-01-22 | 2026-10-21 |
| Analysis of the Effect of Iron Supplements on Iron Deficiency Anemia in Pregnancy Niferex - Iron Deficiency Anemia of Pregnancy, Iron Storage Disease | Phase 4 | Unknown | Qianfoshan Hospital | 452 | 2023-03-28 | 2023-04-07 |
| Quality and Biologic Characteristics of Red Blood Concentrates Obtained From Individuals With Elevated Ferritin. Venipuncture - Hereditary Hemochromatosis, Hyperferritinemia | Not applicable | Unknown | Interregionale Blutspende SRK | 100 | 2023-01-18 | 2023-02-23 |
| A Study to Evaluate BBI-001 in Hereditary Haemochromatosis (HH) Patients and Iron Deficient Volunteers BBI-001, Original Fibre Metamucil - Hereditary Hemochromatosis | Phase 1 | Terminated | Bond Biosciences | 24 | 2022-03-28 | 2023-08-02 |
| MRI QSM Imaging for Iron Overload Magnetic Resonance Imaging (MRI)-based Quantitative Susceptibility Mapping (QSM) - Hemochromatosis, Iron Overload | Completed | University of Wisconsin, Madison | 63 | 2022-01-18 | 2024-05-09 | |
| Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis Clinical examination, SF36 questionnaire, AIMS2_SF questionnaire - Haemochromatosis | Not applicable | Active not recruiting | Rennes University Hospital | 239 | 2021-07-02 | 2026-06-12 |
| An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic Steatosis Chronic Liver Disease | Recruiting | University of Copenhagen | 335 | 2020-08-24 | 2022-04-19 | |
| PTG-300 in Subjects With Hereditary Hemochromatosis PTG-300 - Hereditary Hemochromatosis | Phase 2 | Completed | Protagonist Therapeutics, Inc. | 16 | 2020-03-19 | 2025-08-20 |
| Effects of Polyphenols on Iron Absorption in Iron Overload Disorders. polyphenols, Placebo - Dysmetabolic Iron Overload Syndrome, Genetic Hemochromatosis | Not applicable | Completed | University Hospital, Clermont-Ferrand | 41 | 2018-04-09 | 2026-08-03 |
| Study to Evaluate the Efficacy and Safety of Deferasirox Film-coated Tablet Versus Phlebotomy in Patients With Hereditary Hemochromatosis (HH) Deferasirox FCT, Phlebotomy - Hereditary Hemochromatosis | Phase 2 | Terminated | Novartis Pharmaceuticals | 45 | 2018-01-11 | 2024-10-09 |
| A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis LJPC-401, Placebo - Hereditary Hemochromatosis | Phase 2 | Completed | La Jolla Pharmaceutical Company | 70 | 2017-11-29 | 2022-06-09 |
| Repeatability and Reproducibility of Multiparametric MRI LiverMultiScan - Liver Diseases, Primary Biliary Cirrhosis | Completed | Perspectum | 61 | 2017-06-03 | 2025-12-01 | |
| Transferrin Saturation and Asthenia in Hemochromatosis Hemochromatoses, Genetic | Completed | Rennes University Hospital | 260 | 2017-04-10 | 2019-07-31 | |
| Implications for Quality of Life and Quality of Care in Patients With Hereditary Haemochromatosis Interviews, questionaires, RAND-modified delphi method round - Hereditary Haemochromatosis | Withdrawn | Universitaire Ziekenhuizen KU Leuven | 2016-04-01 | 2023-03-31 | ||
| Confounder-Corrected Quantitative MRI Biomarker of Hepatic Iron Content MRI - Iron Overload, Hemochromatosis | Completed | University of Wisconsin, Madison | 207 | 2015-08-12 | 2025-08-12 | |
| China Registry for Genetic / Metabolic Liver Diseases Standard of care - Genetic/Metabolic Liver Diseases | Recruiting | Beijing Friendship Hospital | 20000 | 2015-06-13 | 2017-04-27 | |
| Treatment of Refractory Hemochromatosis Rheumatism by Anakinra: a Preliminary Phase II Study Anakinra - Refractory Hemochromatosis Rheumatism | Phase 2 | Terminated | Rennes University Hospital | 17 | 2015-02-04 | 2019-03-12 |
| Respiratory Variations For Assessing Blood Withdrawal echography - Genetic Hemochromatosis | Completed | University Hospital, Lille | 27 | 2015-02-01 | 2017-02-28 | |
| Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis. iron fumarate - Hemochromatosis, Type 4, Ferroportin Disease | Phase 2 | Completed | Rennes University Hospital | 62 | 2014-02-10 | 2019-03-27 |
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Iron Overload (19) · Thalassemia (8) · Hematologic Diseases (5) · Anemia, Sickle Cell (3) · beta-Thalassemia (3) · Cholangitis, Sclerosing (2) · Fibrosis (2) · Hemosiderosis (2) · Hepatitis, Autoimmune (2) · Hyperferritinemia (2) · Liver Cirrhosis (2) · Liver Cirrhosis, Biliary (2) · Liver Diseases (2) · Myelodysplastic Syndromes (2)
Iron Metabolism Disorders (54) · Metabolic Diseases (54) · Metabolism, Inborn Errors (54) · Metal Metabolism, Inborn Errors (54) · Nutritional and Metabolic Diseases (54) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (53) · Genetic Diseases, Inborn (53) · Iron Overload (35) · Hemic and Lymphatic Diseases (15) · Anemia, Hemolytic (11) · Anemia, Hemolytic, Congenital (11) · Anemia (10) · Hematologic Diseases (10) · Hemoglobinopathies (10) · Digestive System Diseases (7)
Phlebotomy (8) · Deferoxamine (5) · Deferasirox (4) · Deferiprone (3) · Long Interspersed Nucleotide Elements (2) · Biological Specimen Banks (1) · Bloodletting (1) · Erythrocyte Transfusion (1) · High-Energy Shock Waves (1) · Hydroxyurea (1) · Interleukin 1 Receptor Antagonist Protein (1) · Interviews as Topic (1) · Iron Chelating Agents (1) · Magnetic Resonance Imaging (1) · Magnetic Resonance Spectroscopy (1)
Rennes University Hospital (8) · National Heart, Lung, and Blood Institute (NHLBI) (5) · Novartis Pharmaceuticals (3) · Bond Biosciences (2) · Lipomed (2) · Sanquin Research & Blood Bank Divisions (2) · St. Jude Children's Research Hospital (2) · University of Wisconsin, Madison (2) · ApoPharma (1) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Ospedaliero-Universitaria di Modena (1) · Beijing Friendship Hospital (1) · Boston Children's Hospital (1) · CSL Behring (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1)
France (16) · United States (16) · Australia (6) · Italy (6) · Netherlands (5) · Belgium (4) · Canada (4) · Switzerland (4) · United Kingdom (4) · China (3) · Denmark (2) · Egypt (2) · Germany (2) · Norway (2) · Romania (2)
Curtis Scribner, MD (2) · Eva Rombout, MD (2) · Amal M El-Beshlawy, Prof. Dr. (1) · Annick Vanclooster (1) · Antonio Piga, M.D. (1) · Bernard Cribier, MD (1) · Bruno Laviolle, MD, PhD (1) · Christine Mc Laren (1) · Christine McLaren (1) · David Reboussin (1) · Diego Hernando, PhD (1) · Emily Harris (1)
PMID 17959863, PMID 18055982, PMID 18351337, PMID 19863539, PMID 20658587, PMID 21826782, PMID 21848963, PMID 22144108, PMID 22180427, PMID 22318199, PMID 2265118, PMID 23861242, PMID 24385534, PMID 24914136, PMID 24916507, PMID 25284616, PMID 25345697, PMID 26270952, PMID 28624580, PMID 29195602, PMID 33368569, PMID 34522876, PMID 35668470, PMID 36194113, PMID 36520162, PMID 37863080, PMID 37975597, PMID 39238238, PMID 40671462, PMID 9633879
2014 (1), 2016 (1), 2025 (1), R01DK088988 (1), R01DK100651 (1), R01DK117354 (1), R01HL061428 (1), R15HL058203 (1), U01HL078787 (1)