19 completed, 8 unknown, 2 active not recruiting, 1 enrolling by invitation. 31 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 31 | Completed 19, Unknown 8, Active not recruiting 2, Enrolling by invitation 1, Withdrawn 1 |
Follow Thalassemia: new trials by email Literature Review of Thalassemia trials Research Report on Thalassemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Hydroxyurea and Metformin in Transfusion Dependent Beta-Thalassemia Tablet Metformin (Group A), Tablet Hydroxyurea (Group B) - Transfusion Dependent Beta-thalassemia | Phase 4 | Completed | Bahria University | 96 | 2024-09-16 | 2026-04-28 |
| A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an Agios-Sponsored Mitapivat Study Mitapivat - Pyruvate Kinase Deficiency, Anemia, Hemolytic | Phase 4 | Enrolling by invitation | Agios Pharmaceuticals, Inc. | 55 | 2023-07-06 | 2026-10-28 |
| A Study to Evaluate the Safety and Effectiveness of Luspatercept for the Treatment of Transfusion-dependent (TD) Anemia Associated With Myelodysplastic Syndromes (MDS) & Beta-thalassemia (β-Thal) in India Luspatercept - Anemia | Phase 4 | Active not recruiting | Bristol-Myers Squibb | 85 | 2023-06-05 | 2026-08-31 |
| The Safety and Efficiency of Luspatercept in Chinese Adults With Transfusion Dependent β-thalassemia: a Real-world Study Luspatercept Injectable Product - Thalassemia Major, Transfusion-dependent Anemia | Phase 4 | Unknown | Sun Yat-sen University | 20 | 2022-07-01 | 2022-07-18 |
| Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study Busulfan, Cyclophosphamide, Fludarabine - Thalassemia Major | Phase 4 | Completed | First Affiliated Hospital of Guangxi Medical University | 823 | 2019-07-05 | 2024-08-09 |
| Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children Deferiprone oral solution, Placebo - Beta Thalassemia Major Anemia, Iron Overload | Phase 4 | Completed | Chiesi Canada Corp | 64 | 2018-11-09 | 2024-03-15 |
| Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients Blood component A, Blood component B - Thalassemia Major | Phase 4 | Completed | Università degli Studi di Ferrara | 55 | 2018-05-14 | 2021-11-12 |
| Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency) Colla corii asini, a Simulate Agent of Colla corii asini granule - Thalassemia | Phase 4 | Unknown | The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine | 480 | 2018-03-01 | 2018-12-27 |
| Study on the Mechanism of Colla Corri Asini in the Treatment of Thalassemia Patients With Pregnancy Anemia Colla corii asini - Thalassemia, Pregnancy | Phase 4 | Unknown | The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine | 70 | 2017-12-01 | 2018-01-16 |
| Hyalornic Acid Level in β-Thalassemic Children Treated for Hepatitis C Virus Ledipasvir 90 MG / Sofosbuvir 400 MG [Harvoni] - Beta-Thalassemia, Hepatitis C | Phase 4 | Completed | Tanta University | 50 | 2017-10-01 | 2019-05-23 |
| Sofosbuvir/Ledipasvir for Hepatitis C Genotype 1-6 in Patients With Transfusion-Dependent Thalassemia: An Open Label Trial sofosbuvir/velpatasvir - Thalassemia, Hepatitis C | Phase 4 | Completed | Ala'a Sharara | 7 | 2017-05-01 | 2018-10-11 |
| Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major Busulfan, Cyclophosphamide, Fludarabine - Thalassemia Major | Phase 4 | Unknown | First Affiliated Hospital of Guangxi Medical University | 30 | 2017-04-01 | 2017-05-31 |
| The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Major Metformin - Beta Thalassemia Major Anemia | Phase 4 | Unknown | Cairo University | 60 | 2016-12-01 | 2018-07-18 |
| L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension L-arginine, Sildenafil - Thalassemia | Phase 4 | Unknown | Sherief Abd-Elsalam | 60 | 2016-07-01 | 2018-08-27 |
| Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major Basiliximab,, Tacrolimus, Methotrexate - Beta-Thalassemia Major, Graft-versus-host Disease (GVHD) | Phase 4 | Completed | Zhongming Zhang | 205 | 2015-04-01 | 2025-06-18 |
| CINC424A2X01B Rollover Protocol ruxolitinib, panobinostat - Primary Myelofibrosis, Polycythemia Vera | Phase 4 | Active not recruiting | Novartis Pharmaceuticals | 279 | 2015-03-05 | 2026-10-19 |
| Effect of Deferasirox on Endocrine Complications in Subjects With Transfusion Dependent Thalassemia deferasirox - Thalassemia (Transfusion Delendent) | Phase 4 | Withdrawn | Novartis Pharmaceuticals | 2014-12-01 | 2017-04-20 | |
| Zinc Supplementation on Cellular Immunity in Thalassemia Major Zinc Sulfate, Sucrose Syrup - Thalassemia, Splenectomy; Status | Phase 4 | Completed | Fakultas Kedokteran Universitas Indonesia | 58 | 2013-09-01 | 2017-04-17 |
| Post Hematopoietic Stem Cell Transplantation ICL670 - Iron Overload After Hematopoietic Stem Cell Transplantation (HSCT) in Patients With Beta-thalassemia Major | Phase 4 | Completed | Novartis Pharmaceuticals | 27 | 2013-09-01 | 2016-10-24 |
| Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in Indonesia Zinc, Sucrose, PCV Vaccine - Thalassemia, Pneumococcal Infection | Phase 4 | Completed | Fakultas Kedokteran Universitas Indonesia | 56 | 2013-09-01 | 2017-03-29 |
Showing 20 of 31. Sign in to see all of them.
beta-Thalassemia (17) · Iron Overload (8) · Hepatitis C (3) · Anemia (2) · Anemia, Sickle Cell (2) · Graft vs Host Disease (2) · Hemosiderosis (2) · Myelodysplastic Syndromes (2) · Anemia, Hemolytic (1) · Bone Marrow Diseases (1) · Bronchiolitis Obliterans Syndrome (1) · Hematologic Diseases (1) · Hemochromatosis (1) · Hemoglobinopathies (1)
Anemia, Hemolytic, Congenital (31) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (31) · Genetic Diseases, Inborn (31) · Hemic and Lymphatic Diseases (31) · Anemia, Hemolytic (30) · Hematologic Diseases (30) · Hemoglobinopathies (30) · Anemia (29) · Iron Metabolism Disorders (8) · Metabolic Diseases (8) · Nutritional and Metabolic Diseases (8) · Infections (4) · Blood-Borne Infections (3) · Bone Marrow Diseases (3)
Deferasirox (6) · Deferiprone (4) · Deferoxamine (3) · Methotrexate (3) · Mycophenolic Acid (3) · Tacrolimus (3) · Basiliximab (2) · Busulfan (2) · Cyclophosphamide (2) · Influenza Vaccines (2) · Zinc Sulfate (2) · colla corii asini (2) · fludarabine (2) · luspatercept (2) · thymoglobulin (2)
Novartis Pharmaceuticals (8) · Fakultas Kedokteran Universitas Indonesia (2) · First Affiliated Hospital of Guangxi Medical University (2) · The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine (2) · Agios Pharmaceuticals, Inc. (1) · Ala'a Sharara (1) · ApoPharma (1) · Azienda Ospedaliera V. Cervello (1) · Bahria University (1) · Baqiyatallah Medical Sciences University (1) · Boston Children's Hospital (1) · Bristol-Myers Squibb (1) · Cairo University (1) · Chiesi Canada Corp (1) · Royal Brompton & Harefield NHS Foundation Trust (1)
China (7) · Egypt (5) · Italy (5) · Greece (3) · Indonesia (3) · Lebanon (3) · Turkey (Türkiye) (3) · Australia (2) · Belgium (2) · Canada (2) · France (2) · Hungary (2) · India (2) · Israel (2) · Japan (2)
Yanfang Li, PhD (2) · Yongrong Lai, MD (2) · Antonio Piga, M.D. (1) · Ayesha Khan, MBBS MPhil (1) · Bita Behnava, M.D. (1) · Deborah Chirnomas, MD (1) · Eman El-Khateeb, Msc (1) · Fariborz Mansour-Ghanaei, M.D. (1) · Jianpei Fang, Dr. (1) · Maria Rita Gamberini, MD (1) · Maria Vogiatzi, MD (1) · Markissia Karagiorga, M.D. (1)
PMID 16273116, PMID 16737942, PMID 18298856, PMID 19236376, PMID 19407319, PMID 19724055, PMID 29155313, PMID 31723837, PMID 37975597, PMID 41730859
2014 (1)