9 completed, 4 terminated, 1 active not recruiting, 1 recruiting. 16 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 9, Terminated 4, Active not recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 1 | 4 | Completed 2, Active not recruiting 1, Terminated 1 |
Follow T-Cell Large Granular Lymphocyte Leukemia: new trials by email Literature Review of T-Cell Large Granular Lymphocyte Leukemia trials Research Report on T-Cell Large Granular Lymphocyte Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia Ruxolitinib - T-Cell Large Granular Lymphocyte Leukemia | Phase 2 | Recruiting | Jonathan Brammer | 30 | 2023-05-03 | 2026-10-01 |
| Oral Azacitidine for the Treatment of Relapsed or Refractory T-cell Large Granular Lymphocytic Leukemia Oral Azacitidine - T-Cell Large Granular Lymphocyte Leukemia | Phase 1 / Phase 2 | Active not recruiting | Jonathan Brammer | 11 | 2022-06-29 | 2026-10-21 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas brentuximab vedotin, rituximab, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Terminated | Northwestern University | 20 | 2013-03-05 | 2021-09-01 |
| Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant lenalidomide, rituximab, pharmacological study - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 3 | 2012-05-01 | 2017-07-27 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Akt inhibitor MK2206, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 60 | 2010-12-01 | 2020-11-04 |
| Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies double-unit umbilical cord blood transplantation, cytogenetic analysis, bone marrow aspiration - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Case Comprehensive Cancer Center | 14 | 2007-09-01 | 2019-01-23 |
| Sunitinib in Treating Patients With Idiopathic Myelofibrosis sunitinib malate - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Phase 2 | Terminated | National Cancer Institute (NCI) | 14 | 2006-09-01 | 2014-05-28 |
| Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia tipifarnib, laboratory biomarker analysis - Stage III Chronic Lymphocytic Leukemia, Stage IV Chronic Lymphocytic Leukemia | Phase 2 | Terminated | National Cancer Institute (NCI) | 25 | 2006-06-02 | 2017-04-05 |
| Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Fludarabine Phosphate - Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 66 | 2004-12-01 | 2019-07-11 |
| Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2003-09-01 | 2020-01-18 |
| Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies alemtuzumab, fludarabine phosphate, total-body irradiation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Completed | Fred Hutchinson Cancer Center | 60 | 2001-11-01 | 2020-01-29 |
| Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer total-body irradiation, fludarabine phosphate, cyclosporine - Acute Undifferentiated Leukemia, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 21 | 2000-05-01 | 2020-01-21 |
Leukemia, Large Granular Lymphocytic (16) · Leukemia, Lymphocytic, Chronic, B-Cell (14) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (12) · Leukemia, Hairy Cell (11) · Lymphoma, B-Cell, Marginal Zone (11) · Lymphoma, Extranodal NK-T-Cell (11) · Lymphoma, Follicular (11) · Lymphoma, Non-Hodgkin (11) · Lymphoma, T-Cell, Cutaneous (11) · Mycosis Fungoides (11) · Sezary Syndrome (11) · Waldenstrom Macroglobulinemia (11) · Lymphoma, Large B-Cell, Diffuse (10) · Lymphoma, Large-Cell, Anaplastic (10) · Lymphoma, Large-Cell, Immunoblastic (10)
Hematologic Diseases (16) · Hemic and Lymphatic Diseases (16) · Immune System Diseases (16) · Immunoproliferative Disorders (16) · Leukemia (16) · Leukemia, Lymphoid (16) · Leukemia, T-Cell (16) · Lymphatic Diseases (16) · Lymphoproliferative Disorders (16) · Neoplasms (16) · Neoplasms by Histologic Type (16) · Chronic Disease (14) · Disease Attributes (14) · Leukemia, B-Cell (14) · Pathologic Processes (14)
Mycophenolic Acid (8) · Peripheral Blood Stem Cell Transplantation (7) · Whole-Body Irradiation (7) · fludarabine phosphate (7) · Cyclosporine (5) · Cyclophosphamide (3) · Rituximab (3) · Tacrolimus (3) · Busulfan (2) · Cyclosporins (2) · Transplantation (2) · Alemtuzumab (1) · Antilymphocyte Serum (1) · Azacitidine (1) · Brentuximab Vedotin (1)
Fred Hutchinson Cancer Center (5) · National Cancer Institute (NCI) (3) · Jonathan Brammer (2) · Case Comprehensive Cancer Center (1) · Northwestern University (1) · Roswell Park Cancer Institute (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Chicago (1) · University of Medicine and Dentistry of New Jersey (1)
United States (16) · Italy (4) · Denmark (1) · Germany (1)
Brenda Sandmaier (2) · Jonathan Brammer, MD (2) · Mohamed Sorror (2) · Adam Petrich, MD (1) · Brenda Cooper, MD (1) · David Maloney (1) · George Chen (1) · Hongtao Liu (1) · Roger Strair (1) · Srdan Verstovsek (1) · Thomas Loughran (1) · Usama Gergis, MD (1) · Yasuhiro Oki (1)
PMID 32499241, PMID 19900571, PMID 26213141
P30CA015704 (5), P01CA018029 (3), N01CM62202 (2), N01CM00039 (1), P01CA078902 (1), P30CA016672 (1), P30CA072720 (1), U01CA062502 (1)