9 completed, 5 unknown, 1 not yet recruiting, 1 suspended. 17 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 9, Unknown 5, Not yet recruiting 1, Suspended 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
Follow Stomatitis, Aphthous: new trials by email Literature Review of Stomatitis, Aphthous trials Research Report on Stomatitis, Aphthous
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis 35% Topical Bromelain in Orabase, 50% Topical Bromelain in Orabase, 0.1% Topical Triamcinolone Acetonide in Orabase - Recurrent Aphthous Stomatitis | Phase 2 | Not yet recruiting | Cairo University | 63 | 2025-06-15 | 2025-05-28 |
| Mucoadhesive Film With/without Acmella Oleracea & Triamcinolone Acetonide for Aphthous Ulcers mucoadhesive film with Acmella oleracea extract, Triamcinolone Acetonide 0.1% Oromucosal Paste, mucoadhesive film without Acmella oleracea extract - Aphthous Stomatitis | Phase 2 | Unknown | Khon Kaen University | 72 | 2024-10-15 | 2024-10-02 |
| α-Mangostin Hydrogel Film With Chitosan Alginate Base for Recurrent Aphthous Stomatitis (RAS) α-Mangostin Hydrogel Film With Chitosan Alginate Base, Placebo - Recurrent Aphthous Stomatitis | Phase 2 | Unknown | Universitas Padjadjaran | 48 | 2023-12-04 | 2023-11-15 |
| Basil Extract (Ocimum Basilicum) in the Management of Recurrent Aphthous Stomatitis use of basil extract gel in treatment of aphthus ulcer, muco adhesive placebo gel, no treatment - Oral Ulcer | Phase 2 | Unknown | Tanta University | 30 | 2021-01-01 | 2021-07-14 |
| Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Huanglian-Jiedu Decoction - Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis | Phase 1 / Phase 2 | Unknown | China Academy of Chinese Medical Sciences | 240 | 2018-04-04 | 2018-04-10 |
| Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis Bacilor, Placebo - Aphthous Stomatitis | Phase 2 | Completed | Centre Hospitalier Universitaire de Nice | 20 | 2018-01-04 | 2026-03-24 |
| Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Lactobacillus acidophilus and Bifidobacterium lactis, Placebo - Periodic Fever, Aphthous Stomatitis | Phase 2 | Withdrawn | Connecticut Children's Medical Center | 2016-10-01 | 2018-01-24 | |
| Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients omega-3, placebo - Recurrent Mouth Ulcers | Phase 2 | Unknown | October 6 University | 50 | 2012-04-01 | 2013-04-15 |
| Anakinra for Behcet s Disease Anakinra - Autoimmune Connective Tissue Disorder, Immune System Diseases | Phase 1 / Phase 2 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 6 | 2011-09-01 | 2017-05-12 |
| Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases NAVS Naphthalan, 0.05% Betamethasone dipropionate - Oral Lichen Planus, Recurrent Aphthous Stomatitis | Phase 2 | Completed | Ivan Alajbeg | 57 | 2010-12-01 | 2016-09-30 |
| Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Ibuprofen, Diphenhydramine and Aluminium MgS, Diphenhydramine and Aluminium MgS - Aphthous Stomatitis | Phase 2 | Completed | Qazvin University Of Medical Sciences | 37 | 2010-11-01 | 2012-06-20 |
| Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Yunnan Baiyao toothpaste, Placebo toothpaste - Recurrent Aphthous Stomatitis | Phase 2 | Completed | Peking University | 227 | 2010-03-01 | 2012-07-30 |
| Efficacy of 5% Chitosan Nanoparticle Paste in the Treatment of Recurrent Aphthous Stomatitis Triamcinolone Acetonide 0.1% Oral Paste, 5 wt.% Chitosan Nanoparticle Paste - Recurrent Aphthous Stomatitis, Oral Ulcers | Phase 2 | Completed | Kerman University of Medical Sciences | 30 | 2009-04-21 | 2026-07-14 |
| Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study zinc sulphate 220mg/day in one dosage, placebo: one dosage - Aphthous Stomatitis | Phase 2 | Completed | Qazvin University Of Medical Sciences | 14 | 2008-04-01 | 2010-09-28 |
| Thalidomide to Treat Oral Lesions in HIV-Infected Patients Thalidomide - Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome | Phase 2 | Completed | National Institute of Dental and Craniofacial Research (NIDCR) | 110 | 1996-06-01 | 2008-03-04 |
| Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection Thalidomide - HIV Infections, Stomatitis, Aphthous | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 164 | 2021-11-04 | |
| Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous) Pro-Pe adhesive tablet - Ulcer, Aphthous | Phase 2 | Suspended | Hadassah Medical Organization | 50 | 2007-05-08 |
Oral Ulcer (4) · Acquired Immunodeficiency Syndrome (2) · HIV Infections (2) · AIDS-Related Complex (1) · Behcet Syndrome (1) · Burning Mouth Syndrome (1) · Hereditary Autoinflammatory Diseases (1) · Herpes Labialis (1) · Immune System Diseases (1) · Lichen Planus, Oral (1) · Pharyngitis (1) · Uveitis (1)
Mouth Diseases (17) · Stomatitis (17) · Stomatognathic Diseases (17) · Infections (4) · Skin Diseases (4) · Skin and Connective Tissue Diseases (4) · Virus Diseases (3) · Blood-Borne Infections (2) · Communicable Diseases (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2) · Genital Diseases (2) · Immune System Diseases (2) · Immunologic Deficiency Syndromes (2) · Lentivirus Infections (2)
Triamcinolone Acetonide (3) · Thalidomide (2) · Anti-Inflammatory Agents (1) · Bromelains (1) · Diphenhydramine (1) · Docosahexaenoic Acids (1) · Fish Oils (1) · Gramicidin, Neomycin Sulfate, Nystatin, Triamcinolone Acetonide Drug Combination (1) · Ibuprofen (1) · Interleukin 1 Receptor Antagonist Protein (1) · Lacteol (1) · Ointments (1) · Orabase (1) · Zinc Sulfate (1) · betamethasone-17,21-dipropionate (1)
Qazvin University Of Medical Sciences (2) · Cairo University (1) · Centre Hospitalier Universitaire de Nice (1) · China Academy of Chinese Medical Sciences (1) · Connecticut Children's Medical Center (1) · Hadassah Medical Organization (1) · Ivan Alajbeg (1) · Kerman University of Medical Sciences (1) · Khon Kaen University (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1) · October 6 University (1) · Peking University (1) · Tanta University (1)
United States (3) · Egypt (2) · Iran (2) · China (1) · Croatia (1) · France (1) · Indonesia (1) · Israel (1) · Puerto Rico (1)
Amr M Elkhouli, ass prof (1) · Faeze Mirmiran, D.D.S (1) · Indah Suasani Wahyuni, drg. (1) · Ivan Alajbeg, PhD (1) · Jacobson JM (1) · Kataun Borhanmojabi, DDS,MSC (1) · Katayun Borhanmojabi, D.D.S,M.S (1) · Kemporn Kitsahawong, Ph.D (1) · Nicholas Bennett, MBBChir PhD (1) · Pantea Nazeman, student (1) · Passeron Thierry, PhD (1) · Peter C Grayson, M.D. (1) · Rakefet Czerninski, DMD (1) · Reza Mortazavi, PHD (1)
PMID 28335798, PMID 31954066, PMID 33831097, PMID 38434698
D43DE032294 (1)