4 completed, 3 recruiting, 3 terminated, 1 suspended. 5 Phase 1, 2 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 2, Recruiting 2, Terminated 1 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 2 | 2 | Recruiting 1, Terminated 1 |
Follow Stage IVA Cervical Cancer AJCC v8: new trials by email Literature Review of Stage IVA Cervical Cancer AJCC v8 trials Research Report on Stage IVA Cervical Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 138 | 2022-03-31 | 2026-08-20 |
| Sexual Health Counseling Intervention During Radiation Therapy in Improving Quality of Life for Women With Gynecologic Cancer Counseling, Quality-of-Life Assessment, Questionnaire Administration - Malignant Female Reproductive System Neoplasm, Stage I Cervical Cancer AJCC v8 | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 4 | 2021-05-20 | 2024-05-09 |
| Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes Patient Monitoring, Questionnaire Administration - Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8, Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8 | Completed | City of Hope Medical Center | 22 | 2020-08-11 | 2026-10-14 | |
| Paclitaxel Therapeutic Drug Monitoring in Cancer Patients Blood draws, QLQ-CIPN20 Survey, PR-CTCAE Survey - Solid Tumor, Adult, Metastatic Nonsmall Cell Lung Cancer | Suspended | Wake Forest University Health Sciences | 55 | 2019-11-11 | 2026-08-13 | |
| Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers Quality-of-Life Assessment, Radiation Therapy, Talazoparib - Malignant Female Reproductive System Neoplasm, Recurrent Cervical Carcinoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 24 | 2019-09-26 | 2026-03-11 |
| Atezolizumab Before and/or With Chemoradiotherapy in Immune System Activation in Patients With Node Positive Stage IB2, II, IIIB, or IVA Cervical Cancer Atezolizumab, Brachytherapy, Cisplatin - Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 40 | 2019-01-07 | 2025-11-12 |
| DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457, Durvalumab - Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive | Phase 2 | Terminated | M.D. Anderson Cancer Center | 41 | 2018-11-14 | 2024-07-09 |
| MRI-Guided Brachytherapy in Treating Participants With HPV-Associated Stage IB2-IVA Cervical or Stage II-IVA Vaginal Cancer Internal Radiation Therapy, Magnetic Resonance Imaging - Human Papillomavirus-Related Carcinoma, Human Papillomavirus-Related Cervical Carcinoma | Phase 1 | Terminated | M.D. Anderson Cancer Center | 26 | 2018-08-03 | 2026-09-15 |
| Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers Durvalumab, Laboratory Biomarker Analysis, Stereotactic Radiosurgery - Advanced Cervical Adenocarcinoma, Advanced Vaginal Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 20 | 2018-07-18 | 2023-09-13 |
| Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer Biospecimen Collection, Laboratory Biomarker Analysis - Cervical Adenocarcinoma, Cervical Adenocarcinoma In Situ | Not applicable | Terminated | M.D. Anderson Cancer Center | 409 | 2014-10-27 | 2025-07-14 |
| Establishing a Tumor Registry for Patients With Neuroendocrine Carcinoma of the Cervix Follow-Up, Medical Chart Review - Cervical Large Cell Neuroendocrine Carcinoma, Cervical Neuroendocrine Carcinoma | Recruiting | M.D. Anderson Cancer Center | 750 | 2013-05-16 | 2026-09-14 |
Uterine Cervical Neoplasms (11) · Vaginal Neoplasms (6) · Vulvar Neoplasms (5) · Ovarian Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Renal Cell (2) · Endometrial Neoplasms (2) · Lung Neoplasms (2) · Neoplasm Metastasis (2) · Neoplasms (2) · Anal Canal Carcinoma (1) · Anus Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Lobular (1)
Female Urogenital Diseases (11) · Female Urogenital Diseases and Pregnancy Complications (11) · Genital Diseases (11) · Genital Diseases, Female (11) · Genital Neoplasms, Female (11) · Neoplasms by Site (11) · Urogenital Diseases (11) · Uterine Cervical Diseases (11) · Uterine Diseases (11) · Urogenital Neoplasms (10) · Uterine Neoplasms (10) · Neoplasms (9) · Vaginal Diseases (6) · Vulvar Diseases (5) · Adnexal Diseases (3)
Immunoglobulin G (3) · Brachytherapy (2) · Disulfides (2) · Magnetic Resonance Spectroscopy (2) · Radiation (2) · Radiotherapy (2) · durvalumab (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · Biopsy (1) · Blood Specimen Collection (1) · Chromatin Immunoprecipitation Sequencing (1) · Cisplatin (1) · Colony-Stimulating Factors (1) · Counseling (1) · Cyclophosphamide (1)
M.D. Anderson Cancer Center (6) · City of Hope Medical Center (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1) · Ohio State University Comprehensive Cancer Center (1) · Wake Forest University Health Sciences (1)
United States (11)
Lilie L Lin (2) · Allison M Quick, MD (1) · Ann H Klopp (1) · Jyoti S Mayadev (1) · Kathleen Schmeler (1) · Laleh Melstrom (1) · Larissa A. Meyer (1) · Michael M Frumovitz (1) · Roy Strowd, MD (1) · Yanyan Lou, MD, PhD (1)
P30CA012197 (1), P30CA016672 (1), P30CA033572 (1), U10CA180868 (1)