41 completed, 11 terminated, 1 active not recruiting, 1 withdrawn. 27 Phase 1, 19 Phase 2, 7 Not applicable, 2 Early Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 27 | Completed 19, Terminated 8 |
| Phase 2 | 19 | Completed 15, Terminated 4 |
| Not applicable | 7 | Completed 5, Terminated 1, Withdrawn 1 |
| Early Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
Follow Stage III Small Lymphocytic Lymphoma: new trials by email Literature Review of Stage III Small Lymphocytic Lymphoma trials Research Report on Stage III Small Lymphocytic Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas lenalidomide, etoposide, prednisone - Adult Grade III Lymphomatoid Granulomatosis, B-cell Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Completed | University of Chicago | 55 | 2014-07-29 | 2026-03-11 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL MOR00208, lenalidomide, Correlative Studies - Contiguous Stage II Small Lymphocytic Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 41 | 2014-01-17 | 2025-12-15 |
| Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas brentuximab vedotin, rituximab, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Terminated | Northwestern University | 20 | 2013-03-05 | 2021-09-01 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Bortezomib and Filgrastim to Promote Stem Cell Mobilization in Patients With Non-Hodgkin Lymphoma or Multiple Myeloma bortezomib, filgrastim, autologous hematopoietic stem cell transplantation - Adult Grade III Lymphomatoid Granulomatosis, B-cell Chronic Lymphocytic Leukemia | Not applicable | Completed | Barbara Ann Karmanos Cancer Institute | 23 | 2011-07-01 | 2021-05-10 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Wake Forest University Health Sciences | 16 | 2011-01-01 | 2018-09-07 |
| Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer palifermin, flow cytometry, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Martin, Paul | 6 | 2010-09-01 | 2014-04-02 |
| Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload deferasirox - Iron Overload, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2010-07-01 | 2019-06-18 |
| Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies plerixafor, filgrastim, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Terminated | Fred Hutchinson Cancer Center | 1 | 2010-06-01 | 2017-06-28 |
| RO4929097 and Capecitabine in Treating Patients With Refractory Solid Tumors gamma-secretase/Notch signalling pathway inhibitor RO4929097, capecitabine, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2010-06-01 | 2014-11-07 |
| AR-42 in Treating Patients With Advanced or Relapsed Multiple Myeloma, Chronic Lymphocytic Leukemia, or Lymphoma Pharmacodynamic Studies, Fatigue Inventory, Pharmacogenomic studies - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Amir Mortazavi | 44 | 2010-05-04 | 2018-06-04 |
| Cyclophosphamide, Alvocidib, and Rituximab in Treating Patients With High Risk B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Alvocidib Hydrochloride, Cyclophosphamide, Diagnostic Laboratory Biomarker Analysis - Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 9 | 2010-04-01 | 2015-11-11 |
| Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Cyclophosphamide, Laboratory Biomarker Analysis, Ofatumumab - Chronic Lymphocytic Leukemia, Stage 0 Chronic Lymphocytic Leukemia | Phase 2 | Completed | Mayo Clinic | 82 | 2010-03-01 | 2018-09-18 |
| Lenalidomide And Rituximab as Maintenance Therapy in Treating Patients With B-Cell Non-Hodgkin Lymphoma lenalidomide, rituximab, polymerase chain reaction - Adult Non-Hodgkin Lymphoma, Adult Grade III Lymphomatoid Granulomatosis | Phase 1 | Terminated | Case Comprehensive Cancer Center | 5 | 2010-01-01 | 2015-11-26 |
| Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer rituximab, mycophenolate mofetil, tacrolimus - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Terminated | University of Nebraska | 20 | 2009-12-10 | 2023-09-06 |
| Gossypol, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery R-(-)-gossypol acetic acid, paclitaxel, carboplatin - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 36 | 2009-07-01 | 2013-01-10 |
| FAU in Treating Patients With Advanced Solid Tumors or Lymphoma 2'-F-ara-deoxyuridine, positron emission tomography, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 2009-07-01 | 2014-01-07 |
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Leukemia, Lymphocytic, Chronic, B-Cell (54) · Lymphoma, B-Cell, Marginal Zone (44) · Lymphoma, Follicular (44) · Lymphoma, Mantle-Cell (42) · Lymphoma, Large B-Cell, Diffuse (41) · Burkitt Lymphoma (39) · Lymphoma, Non-Hodgkin (39) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (39) · Lymphoma, Large-Cell, Immunoblastic (37) · Hodgkin Disease (33) · Lymphoma, T-Cell, Cutaneous (31) · Mycosis Fungoides (30) · Sezary Syndrome (30) · Waldenstrom Macroglobulinemia (30) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (24)
Chronic Disease (54) · Disease Attributes (54) · Hematologic Diseases (54) · Hemic and Lymphatic Diseases (54) · Immune System Diseases (54) · Immunoproliferative Disorders (54) · Leukemia, B-Cell (54) · Leukemia, Lymphoid (54) · Lymphatic Diseases (54) · Lymphoproliferative Disorders (54) · Neoplasms (54) · Neoplasms by Histologic Type (54) · Pathologic Processes (54) · Pathological Conditions, Signs and Symptoms (54) · Leukemia (53)
Rituximab (13) · fludarabine phosphate (11) · Cyclophosphamide (9) · Peripheral Blood Stem Cell Transplantation (8) · Whole-Body Irradiation (8) · Mycophenolic Acid (7) · Tacrolimus (5) · Flow Cytometry (4) · Therapeutics (4) · Bortezomib (3) · Cyclosporine (3) · Filgrastim (3) · Granulocyte Colony-Stimulating Factor (3) · Lenalidomide (3) · Polymerase Chain Reaction (3)
National Cancer Institute (NCI) (23) · Fred Hutchinson Cancer Center (12) · Case Comprehensive Cancer Center (3) · City of Hope Medical Center (3) · Roswell Park Cancer Institute (3) · Amir Mortazavi (1) · Barbara Ann Karmanos Cancer Institute (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Martin, Paul (1) · Mayo Clinic (1) · Northwestern University (1) · Ohio State University Comprehensive Cancer Center (1) · University of Chicago (1) · University of Nebraska (1) · Wake Forest University Health Sciences (1)
United States (52) · Italy (3) · Canada (2) · Denmark (2) · Germany (1)
John Byrd (3) · Paul Martin (3) · Brenda Sandmaier (2) · Mazyar Shadman (2) · Ryotaro Nakamura (2) · Adam Petrich, MD (1) · Ajay Gopal (1) · Amir Mortazavi, MD (1) · Ann Woolfrey (1) · Antonius Miller (1) · Brian Hill, MD (1) · Chandra Belani (1) · Charles Erlichman (1) · David Maloney (1) · Divaya Bhutani, M.D. (1)
PMID 32499241, PMID 18698002, PMID 19900571, PMID 24431228, PMID 25085357, PMID 26853648, PMID 26943915, PMID 27118540, PMID 27570087, PMID 28270022, PMID 28817727, PMID 30562587, PMID 31388792, PMID 32628342, PMID 33420905, PMID 33492438, PMID 36282798, PMID 40720747
P30CA015704 (7), U01CA076576 (6), P01CA018029 (4), U01CA062491 (3), P30CA015083 (2), P30CA016058 (2), P30CA022453 (2), U01CA062487 (2), U01CA069912 (2), U01CA099168 (2), U01CA132123 (2), N01CM62208 (1), P01CA078902 (1), P30CA014520 (1), P30CA014599 (1)