209 completed, 58 terminated, 57 recruiting, 37 unknown. 213 Phase 1, 161 Phase 2, 32 Phase 3, 26 Not applicable, 9 Early Phase 1.
Follow Precursor T-Cell Lymphoblastic Leukemia-Lymphoma: new trials by email Literature Review of Precursor T-Cell Lymphoblastic Leukemia-Lymphoma trials Research Report on Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Universal 4SCAR7U Targeting CD7-positive Malignancies Universal CD7-specific CAR gene-engineered T cells - T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-08-26 |
| Multi-CAR T Cell Therapy Targeting CD7-positive Malignancies CD7-specific CAR gene-engineered T cells - T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2026-12-31 | 2026-08-26 |
| Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies aldesleukin, cyclophosphamide, fludarabine phosphate - Malignancy, Hematologic, Neoplasms, Hematologic | Phase 1 | Recruiting | National Cancer Institute (NCI) | 86 | 2026-10-27 | 2026-10-22 |
| Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Not yet recruiting | SWOG Cancer Research Network | 90 | 2026-10-14 | 2026-10-13 |
| HEM-iSMART E: Capivasertib + Venetoclax + Dexamethasone in Pediatric Patients With Relapsed or Refractory Hematological Malignancies Capivasertib, Venetoclax, Dexamethasone - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Phase 1 / Phase 2 | Not yet recruiting | Princess Maxima Center for Pediatric Oncology | 42 | 2026-10-01 | 2025-09-16 |
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Chidamide Maintenance to Prevent Relapse After Allogeneic Hematopoietic Stem Cell Transplantation in Acute T-Lymphoblastic Leukemia/Lymphoma Chidamide, Control Group - T-Cell Acute Lymphoblastic Leukemia, T-Cell Lymphoblastic Lymphoma | Phase 3 | Not yet recruiting | First Affiliated Hospital of Zhejiang University | 132 | 2026-08-15 | 2026-08-19 |
| A Clinical Study of HY035 Cell Injection in the Treatment of CD7-positive Relapsed or Refractory Hematologic Malignancies HY035 cell injection - Acute T Cell Lymphoblastic Leukemia, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory | Phase 1 | Enrolling by invitation | Institute of Hematology & Blood Diseases Hospital, China | 13 | 2026-08-15 | 2026-08-25 |
| A Multicenter, Open-label, Non-randomized, Single-arm Phase 1/2 Study of Autologous Nano CD5-CAR T Cells for the Treatment of Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma Autologous nano CD5-CAR T Cells - T-Cell Acute Lymphoblastic Leukemia, T-Lymphoblastic Lymphoma | Phase 1 / Phase 2 | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 18 | 2026-06-30 | 2026-07-01 |
| Venetoclax, Dexamethasone, Bortezomib, and Daratumumab For The Treatment Of Adolescent And Young Adults With Relapsed Or Refractory T-Cell Acute Lymphoblastic Leukemia And T-cell Acute Lymphoblastic Lymphoma Venetoclax, Dexamethasone, Bortezomib - T-cell Acute Lymphoblastic Leukemia, Lymphoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 18 | 2026-06-05 | 2026-08-12 |
| Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients Acute Lymphoblastic Leukemia | Recruiting | Washington University School of Medicine | 60 | 2026-06-03 | 2026-10-09 | |
| NGS-MRD Assessment of Combination Immunotherapies Targeting T-ALL Antigen-specific T cells CAR-T/CTL and DCvac - T-Cell Acute Lymphoblastic Leukemia | Phase 1 | Terminated | Shenzhen Geno-Immune Medical Institute | 10 | 2026-06-01 | 2026-08-24 |
| Novel Unedited Allo Cell Therapy For High Risk T-Cell Malignancies Using CD7-Specific Car T Cells CD7.CAR/28zeta T Cells - T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma | Phase 1 | Recruiting | Baylor College of Medicine | 27 | 2026-05-12 | 2026-05-18 |
| Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Bone Marrow Collection - B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, T Acute Lymphoblastic Leukemia | Phase 2 | Suspended | University of Washington | 30 | 2026-05-08 | 2026-09-29 |
| Autologous Versus Allogeneic Hematopoietic Stem Cell Transplantation for T-Lymphoblastic Leukemia/Lymphoma in First Complete Remission different stem cell transplantation type - T Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 84 | 2026-05-05 | 2026-05-13 | |
| Azacitidine and Abatacept in Relapsed or Refractory T-Cell Lymphoma azacitidine, abatacept - Lymphoma, T Cell, Peripheral, T-cell Lymphoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 20 | 2026-03-26 | 2026-10-20 |
| Efficacy and Safety of CD7 CAR-T in Newly Diagnosed High-Risk T-LBL/ALL CD7 CAR-T cell intravenous infusion - T Lymphoblastic Lymphoma, T Acute Lymphoblastic Leukemia | Early Phase 1 | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 10 | 2026-03-15 | 2026-03-17 |
| Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies Autologous CD19/CD22 dual-target CAR-T module, Autologous CD19/CD20 dual-target CAR-T module, Autologous BCMA/CD19 dual-target CAR-T module - Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia, Relapsed/Refractory B-cell Non-Hodgkin Lymphoma or CLL/SLL | Phase 1 / Phase 2 | Recruiting | Beijing Biotech | 96 | 2026-03-02 | 2026-04-13 |
| Ruxolitinib Maintenance Post-Hematopoietic Stem Cell Transplant T-Cell Lymphoma Ruxolitinib, Positron emission tomography-computed tomography, Bone Marrow Biopsy - T-cell Lymphoma, Graft Versus Host Disease | Phase 2 | Recruiting | Jonathan Brammer | 44 | 2026-02-12 | 2026-04-15 |
| Safety and Efficacy of GYA01 (CART84) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Acute Lymphoblastic T Leukemia Patients (T-ALL). CART84 - Acute Myeloblastic Leukaemia, Leukemia, T-Cell | Phase 1 / Phase 2 | Recruiting | Gyala Therapeutics | 33 | 2026-02-04 | 2026-03-13 |
Showing 20 of 419. Sign in to see all of them.
Precursor Cell Lymphoblastic Leukemia-Lymphoma (259) · Burkitt Lymphoma (224) · Lymphoma, Large B-Cell, Diffuse (219) · Lymphoma, Follicular (217) · Lymphoma, Large-Cell, Anaplastic (215) · Lymphoma, Mantle-Cell (215) · Leukemia, Lymphocytic, Chronic, B-Cell (214) · Lymphoma, B-Cell, Marginal Zone (207) · Lymphoma, Non-Hodgkin (207) · Immunoblastic Lymphadenopathy (202) · Lymphoma, T-Cell, Cutaneous (201) · Hodgkin Disease (200) · Lymphoma, Large-Cell, Immunoblastic (195) · Mycosis Fungoides (185)
Hematologic Diseases (419) · Hemic and Lymphatic Diseases (419) · Immune System Diseases (419) · Immunoproliferative Disorders (419) · Neoplasms by Histologic Type (419) · Lymphatic Diseases (418) · Leukemia, Lymphoid (417) · Neoplasms (398) · Lymphoproliferative Disorders (392) · Leukemia (302) · Pathologic Processes (247) · Pathological Conditions, Signs and Symptoms (247) · Lymphoma, B-Cell (246) · Disease Attributes (244) · Lymphoma, T-Cell (235)
Cyclophosphamide (64) · fludarabine phosphate (40) · Peripheral Blood Stem Cell Transplantation (34) · Methotrexate (31) · Vincristine (31) · Cytarabine (29) · Etoposide (29) · Dexamethasone (28) · Doxorubicin (26) · Whole-Body Irradiation (25) · Mycophenolic Acid (23) · Prednisone (22) · Filgrastim (21) · Tacrolimus (21) · Busulfan (19)
National Cancer Institute (NCI) (58) · Fred Hutchinson Cancer Center (19) · Memorial Sloan Kettering Cancer Center (13) · City of Hope Medical Center (11) · M.D. Anderson Cancer Center (11) · Mayo Clinic (10) · National Institutes of Health Clinical Center (CC) (9) · Case Comprehensive Cancer Center (8) · Eastern Cooperative Oncology Group (7) · Jonsson Comprehensive Cancer Center (7) · European Organisation for Research and Treatment of Cancer - EORTC (6) · Northwestern University (6) · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (6) · Barbara Ann Karmanos Cancer Institute (5) · Children's Oncology Group (5)
United States (285) · China (50) · Italy (27) · France (23) · Germany (23) · Canada (15) · United Kingdom (14) · Belgium (11) · Switzerland (11) · Australia (10) · Netherlands (10) · Spain (10) · Israel (9) · Japan (8) · Austria (6)
David Maloney (4) · Shivaani Kummar, MD (4) · Ajay Gopal (3) · Brenda Sandmaier (3) · Cherry Thomas, MD (3) · John A. Glaspy, MD, MPH (3) · Michel Zwaan, Prof. Dr. (3) · Rayne Rouce, MD (3) · Roger Strair, MD, PhD (3) · Abhinav Deol, M.D. (2) · Andrej Lissat, MD PhD (2) · Ann Woolfrey (2) · Asad Bashey, MD, PhD (2) · David G. Savage, MD (2)
PMID 32499241, PMID 36603187, PMID 36858787, PMID 10552943, PMID 10764422, PMID 11410496, PMID 12525530, PMID 14630685, PMID 15013589, PMID 15459300, PMID 16135477, PMID 16148284, PMID 16195338, PMID 16710026, PMID 17020988, PMID 17119113, PMID 17344466, PMID 17397698, PMID 18226581, PMID 18327587, PMID 18698002, PMID 19141862, PMID 19170225, PMID 19204798, PMID 19451403, PMID 19536896, PMID 19789320, PMID 19841031, PMID 19900571, PMID 20142598, PMID 20166206, PMID 20229590, PMID 21135857, PMID 21247755, PMID 21498721, PMID 21715313, PMID 21715318, PMID 21719599, PMID 21725056, PMID 22259028, PMID 22337718, PMID 22442346, PMID 22480131, PMID 23233571, PMID 23256542, PMID 23335369, PMID 23358983, PMID 24241210, PMID 24276047, PMID 24474568
P30CA015704 (14), P30CA015083 (9), P30CA033572 (9), P30CA072720 (6), U10CA180888 (6), P30CA006973 (5), P30CA043703 (5), U10CA180886 (5), P01CA018029 (4), P30CA016672 (4), P30CA022453 (4), P30CA036727 (4), U01CA062487 (4), U01CA062491 (4), U01CA076576 (4)