51 completed, 7 terminated, 2 withdrawn, 1 active not recruiting. 30 Phase 2, 18 Phase 1, 7 Not applicable, 6 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 30 | Completed 25, Terminated 4, Withdrawn 1 |
| Phase 1 | 18 | Completed 16, Terminated 2 |
| Not applicable | 7 | Completed 5, Terminated 1, Withdrawn 1 |
| Phase 3 | 6 | Completed 6 |
Follow Secondary Myelodysplastic Syndromes: new trials by email Literature Review of Secondary Myelodysplastic Syndromes trials Research Report on Secondary Myelodysplastic Syndromes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies radiation therapy, cyclophosphamide, anti-thymocyte globulin - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 1 | Completed | Sumithira Vasu | 33 | 2015-07-27 | 2023-09-21 |
| CPX-351 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome liposomal cytarabine-daunorubicin CPX-351 - Adult Acute Erythroid Leukemia (M6), Adult Acute Megakaryoblastic Leukemia (M7) | Phase 2 | Completed | Rondeep Brar | 11 | 2014-02-03 | 2019-01-22 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Tosedostat in Combination With Cytarabine or Decitabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome tosedostat, cytarabine, decitabine - Acute Myeloid Leukemia With Multilineage Dysplasia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | Fred Hutchinson Cancer Center | 34 | 2012-05-01 | 2017-02-15 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2011-09-01 | 2017-05-19 |
| A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Fludarabine, Busulfan, Total Body Irradiation (TBI) - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 40 | 2011-08-04 | 2026-04-15 |
| Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant supersaturated calcium phosphate rinse, placebo, questionnaire administration - Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 226 | 2011-03-01 | 2019-09-17 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer palifermin, flow cytometry, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Completed | Martin, Paul | 6 | 2010-09-01 | 2014-04-02 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload deferasirox - Iron Overload, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2010-07-01 | 2019-06-18 |
| Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies plerixafor, filgrastim, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Terminated | Fred Hutchinson Cancer Center | 1 | 2010-06-01 | 2017-06-28 |
| Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant azacitidine, laboratory biomarker analysis - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2010-04-01 | 2017-05-24 |
| 5-Fluoro-2'-Deoxycytidine and Tetrahydrouridine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes 5-fluoro-2-deoxycytidine, tetrahydrouridine, laboratory biomarker analysis - Adult Acute Myeloid Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 | Completed | City of Hope Medical Center | 25 | 2009-12-22 | 2026-10-16 |
| Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer rituximab, mycophenolate mofetil, tacrolimus - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Terminated | University of Nebraska | 20 | 2009-12-10 | 2023-09-06 |
| Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia laboratory biomarker analysis - Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7) | Completed | Children's Oncology Group | 20 | 2009-05-01 | 2016-05-17 |
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Congenital Abnormalities (44) · Leukemia, Myeloid, Acute (43) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (39) · Leukemia, Myelomonocytic, Chronic (34) · Blast Crisis (27) · Leukemia, Lymphocytic, Chronic, B-Cell (26) · Leukemia, Myeloid, Accelerated Phase (26) · Burkitt Lymphoma (25) · Lymphoma, B-Cell, Marginal Zone (24) · Lymphoma, Follicular (24) · Myeloproliferative Disorders (24) · Leukemia, Myeloid, Chronic-Phase (23) · Lymphoma, Large B-Cell, Diffuse (23) · Lymphoma, Mantle-Cell (23) · Lymphoma, Non-Hodgkin (23)
Hematologic Diseases (57) · Hemic and Lymphatic Diseases (57) · Leukemia, Myeloid (56) · Neoplasms (56) · Neoplasms by Histologic Type (56) · Leukemia (55) · Bone Marrow Diseases (53) · Chronic Disease (49) · Disease Attributes (49) · Pathologic Processes (49) · Pathological Conditions, Signs and Symptoms (49) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (47) · Immune System Diseases (39) · Immunoproliferative Disorders (39) · Leukemia, Lymphoid (39)
fludarabine phosphate (16) · Whole-Body Irradiation (14) · Cyclophosphamide (13) · Mycophenolic Acid (13) · Peripheral Blood Stem Cell Transplantation (13) · Cyclosporine (10) · Tacrolimus (10) · Transplantation (9) · Busulfan (8) · Methotrexate (8) · merphos (8) · Cytarabine (6) · Flow Cytometry (5) · Therapeutics (5) · Antilymphocyte Serum (4)
National Cancer Institute (NCI) (21) · Fred Hutchinson Cancer Center (17) · Children's Oncology Group (5) · City of Hope Medical Center (4) · Roswell Park Cancer Institute (3) · Case Comprehensive Cancer Center (2) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Martin, Paul (1) · Nohla Therapeutics, Inc. (1) · Rondeep Brar (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Sumithira Vasu (1) · University of Chicago (1) · University of Medicine and Dentistry of New Jersey (1) · University of Nebraska (1)
United States (59) · Canada (4) · Australia (2) · Germany (1) · Italy (1) · Puerto Rico (1)
Bart Scott (3) · Francis Giles (3) · Paul Martin (3) · Colleen Delaney (2) · George Chen (2) · Johnnie Orozco (2) · Mark Kirschbaum (2) · Ryotaro Nakamura (2) · Alvaro Moreno Aspitia (1) · Amanda Cashen (1) · Andrew Rezvani (1) · Ann Woolfrey (1) · B. Smith (1) · Beverly Lange (1) · Boglarka Gyurkocza (1)
PMID 18698002, PMID 19304957, PMID 19786617, PMID 20056794, PMID 20413658, PMID 21149673, PMID 21791475, PMID 26764356, PMID 26853648, PMID 28389462, PMID 28817727, PMID 30562587, PMID 32628342, PMID 33420905, PMID 35445027, PMID 36282798, PMID 36815378, PMID 38295280, PMID 42085603
P30CA015704 (8), U10CA098543 (4), P01CA018029 (3), P01HL036444 (3), U01CA062461 (3), U01CA062505 (3), U01CA070095 (3), N01CM62202 (2), N01CM62203 (2), N01CM62205 (2), P01CA078902 (2), P30CA015083 (2), RC2HL101844 (2), U01CA062502 (2), K23HL084054 (1)