12 completed, 2 unknown. 3 Phase 2, 3 Phase 3, 2 Not applicable, 2 Phase 1, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 3 |
| Phase 3 | 3 | Completed 3 |
| Not applicable | 2 | Completed 2 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 4 | 2 | Completed 2 |
Follow Rotavirus Infection: new trials by email Literature Review of Rotavirus Infection trials Research Report on Rotavirus Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Preliminary Immunogenicity Study of Inactivated Vaccine for Prevention of Rotavirus Infection Low dosage IRV on a 0- and 28-day schedule, Medium dosage IRV on a 0- and 28-day schedule, High dosage IRV on a 0- and 28-day schedule - Rotavirus Infection | Phase 1 | Unknown | Chinese Academy of Medical Sciences | 32 | 2020-12-03 | 2020-12-10 |
| Reactogenicity, Safety and Immunological Efficacy of the Live, Pentavalent Rotavirus Vaccine in Childhood Immunization The pentavalent rotavirus vaccine (live attenuated oral, freeze-dried), Placebo - Rotavirus Infection | Phase 3 | Completed | Limited Liability Company Pharm Aid | 100 | 2019-02-22 | 2021-09-05 |
| This Study Will Evaluate the Immunogenicity, Reactogenicity and Safety of the Routine Infant Vaccines Pediarix®, Hiberix® and Prevenar 13® When Co-administered With GlaxoSmithKline (GSK) Biologicals' Liquid Human Rotavirus Vaccine (HRV) as Compared to GSK's Licensed Lyophilized Vaccine Rotarix, Pediarix, Hiberix - Rotavirus Infection, Rotavirus Vaccines | Phase 3 | Completed | GlaxoSmithKline | 1280 | 2017-09-14 | 2020-12-29 |
| The Effects of Increased Inoculum on Oral Rotavirus Vaccine Take and Immunogenicity Rotarix, dose 1, Rotarix, dose 2, Placebo (for Rotarix dose 2) - Rotavirus Infection, Vaccine Response Impaired | Phase 4 | Completed | University of Vermont | 220 | 2017-06-12 | 2020-08-04 |
| The Epidemiology and Etiology of Acute Gastroenteritis Among Estonian Children After Introduction of Rotavirus Vaccines Rotavirus Infection | Unknown | University of Tartu | 2260 | 2015-02-01 | 2016-12-21 | |
| A Phase 1 Dose Escalation Study to Examine the Safety of the P2-VP8 Rotavirus Vaccine P2-VP8 subunit rotavirus vaccine, placebo - Rotavirus Infection | Phase 1 | Completed | PATH | 48 | 2012-12-01 | 2019-03-12 |
| Safety and Immunogenicity of Sequential Rotavirus Vaccine Schedules Rotarix®, RotaTeq® - Rotavirus Infection | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 1384 | 2011-03-01 | 2014-10-28 |
| Serological Response to Porcine Circovirus Type 1 (PCV-1) and PCV-1 DNA in Stools of Infants Following Administration of Rotarix™ Stool sample, Serum sample - Rotavirus Infection, Evidence of PCV-1 Replication and/or Immune Response to the PCV-1 in HRV Vaccinated Infants | Completed | GlaxoSmithKline | 1 | 2010-04-01 | 2017-05-16 | |
| Safety and Immune Response of a Rotavirus Vaccine in HIV-infected and Uninfected Children Born to HIV-infected Mothers RotaTeq, Placebo - HIV Infection, Rotavirus Infection | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 202 | 2009-12-01 | 2021-11-05 |
| Two-year Surveillance of Rotavirus Genotypes Causing Acute Diarrhea in Children Younger Than 5 Years Requiring Emergency Room (ER) and Hospital Admission in Chile Acute Diarrheal Disease, Rotavirus Infection | Completed | University of Chile | 967 | 2009-05-01 | 2014-05-01 | |
| Use of Nitazoxanide and Probiotics in Acute Diarrhea Secondary to Rotavirus Nitazoxanide, Probiotic mix preparation, Oral hydration solutions - Diarrhea, Rotavirus Infection | Not applicable | Completed | Centro Pediatrico Albina de Patino | 75 | 2007-08-01 | 2008-05-26 |
| Probiotics in the Management of Acute Rotavirus Diarrhea in Bolivian Children GB (Florestor), GRALB, GC (placebo) - Diarrhea, Rotavirus Infection | Not applicable | Completed | Centro Pediatrico Albina de Patino | 76 | 2007-07-01 | 2009-09-22 |
| Efficacy Study of Nitazoxanide Suspension in the Treatment of Rotavirus Disease in Children Nitazoxanide - Rotavirus Infection, Viral Gastroenteritis Due to Rotavirus | Phase 2 | Completed | Romark Laboratories L.C. | 100 | 2005-12-01 | 2011-04-05 |
| Study of Nitazoxanide Suspension in the Treatment of Diarrhea Caused by Enteric Viruses in Children Alinia (nitazoxanide) - Rotavirus Infection, Adenoviridae Infection | Phase 2 / Phase 3 | Completed | Romark Laboratories L.C. | 50 | 2005-02-01 | 2012-05-31 |
Rotavirus Infections (14) · Diarrhea (3) · Gastroenteritis (2) · Adenoviridae Infections (1) · Caliciviridae Infections (1) · HIV Infections (1) · Tooth, Impacted (1)
Infections (14) · RNA Virus Infections (14) · Reoviridae Infections (14) · Virus Diseases (14) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Signs and Symptoms, Digestive (3) · Digestive System Diseases (2) · Gastrointestinal Diseases (2) · Blood-Borne Infections (1) · Communicable Diseases (1) · DNA Virus Infections (1) · Genital Diseases (1) · Immune System Diseases (1) · Immunologic Deficiency Syndromes (1)
RIX4414 vaccine (3) · nitazoxanide (3) · RotaTeq (2) · 13-valent pneumococcal vaccine (1) · Appointments and Schedules (1) · CRM197 (non-toxic variant of diphtheria toxin) (1) · Freeze Drying (1) · Hepatitis B Vaccines (1) · Hiberix (1) · PEDIARIX (1) · Poliovirus Vaccine, Inactivated (1) · Probiotics (1) · Tetanus Toxoid (1)
Centro Pediatrico Albina de Patino (2) · GlaxoSmithKline (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Romark Laboratories L.C. (2) · Chinese Academy of Medical Sciences (1) · Limited Liability Company Pharm Aid (1) · PATH (1) · University of Chile (1) · University of Tartu (1) · University of Vermont (1)
United States (3) · Bolivia (2) · Bangladesh (1) · Botswana (1) · Chile (1) · China (1) · Egypt (1) · Estonia (1) · Russia (1) · Tanzania (1) · Zambia (1) · Zimbabwe (1)
Mona Abu-Zekry, MD (2) · Benjamin Lee, M.D. (1) · Carlos N Teran, M.D (1) · Clayton Harro, MD (1) · Giuseppe E Grandy, Md (1) · Hongjun Li, Ph.D (1) · Irina V. Feldblium, PhD (1) · Irja Lutsar, PhD (1) · Miguel L O'Ryan, MD (1) · Myron J. Levin, MD (1) · Olga A. Rychkova, Dr. Sci (1) · Richard M Soria, MD (1)
PMID 16829296, PMID 20735858, PMID 21658240, PMID 22221511, PMID 22225699, PMID 22243622, PMID 22272750, PMID 22305197, PMID 26065919, PMID 26823540, PMID 27657348, PMID 27662551, PMID 31607603, PMID 33847298, PMID 38796326, PMID 42733081
2016 (1)