10 recruiting. 10 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Recruiting 10 |
| Phase 2 | 5 | Recruiting 5 |
Follow Refractory Malignant Solid Neoplasm: new trials by email Literature Review of Refractory Malignant Solid Neoplasm trials Research Report on Refractory Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Metastatic Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm | Phase 1 | Recruiting | Mayo Clinic | 42 | 2025-11-07 | 2026-09-24 |
| Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors Biopsy, Biospecimen Collection, Computed Tomography - Metastatic Malignant Solid Neoplasm, Metastatic Melanoma | Phase 1 | Recruiting | Anusha Kalbasi | 18 | 2025-10-07 | 2026-03-17 |
| Studying TAK-243 in Patients With Advanced Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Lymphoma, Advanced Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 95 | 2025-03-24 | 2026-10-13 |
| Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors Axatilimab, Biopsy, Biospecimen Collection - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 / Phase 2 | Recruiting | OHSU Knight Cancer Institute | 38 | 2024-05-21 | 2026-07-08 |
| Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors BET Bromodomain Inhibitor ZEN-3694, Computed Tomography, Core Biopsy - Advanced Malignant Solid Neoplasm, Locally Advanced Pancreatic Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 49 | 2022-11-16 | 2026-07-15 |
| AOH1996 for the Treatment of Refractory Solid Tumors PCNA Inhibitor AOH1996 - Refractory Malignant Solid Neoplasm, Osteosarcoma | Phase 1 | Recruiting | City of Hope Medical Center | 92 | 2022-09-08 | 2026-10-20 |
| Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer BET Bromodomain Inhibitor ZEN-3694, Binimetinib, Biopsy Procedure - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 42 | 2022-08-02 | 2026-10-14 |
| CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma Biospecimen Collection, Bone Marrow Aspirate, Bone Marrow Biopsy - Diffuse Midline Glioma, H3 K27-Altered, Metastatic Malignant Neoplasm in the Central Nervous System | Phase 1 / Phase 2 | Recruiting | Children's Oncology Group | 63 | 2022-01-28 | 2026-09-11 |
| Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors Biospecimen Collection, Dual X-ray Absorptiometry, Tegavivint - Colorectal Carcinoma, Endometrial Carcinoma | Phase 1 / Phase 2 | Recruiting | Children's Oncology Group | 147 | 2021-11-08 | 2026-08-25 |
| Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma Onivyde, Talazoparib, Temozolomide - Recurrent Solid Tumor, Recurrent Ewing Sarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 90 | 2021-06-09 | 2026-05-19 |
Neoplasm Metastasis (5) · Osteosarcoma (3) · Hepatoblastoma (2) · Melanoma (2) · Neuroblastoma (2) · Ovarian Neoplasms (2) · Pancreatic Neoplasms (2) · Sarcoma, Ewing (2) · Wilms Tumor (2) · Adenocarcinoma of Lung (1) · Adenoma, Islet Cell (1) · Adrenocortical Carcinoma (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1)
Neoplasms (9) · Neoplasms by Site (7) · Neoplasms by Histologic Type (5) · Neoplastic Processes (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Endocrine Gland Neoplasms (4) · Endocrine System Diseases (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Neuroectodermal Tumors (4) · Female Urogenital Diseases (3)
Specimen Handling (7) · Biopsy (5) · Magnetic Resonance Spectroscopy (5) · Absorptiometry, Photon (1) · Biopsy, Large-Core Needle (1) · Biopsy, Needle (1) · Bone Density (1) · CBLC137 (1) · Cyclophosphamide (1) · Fluid Therapy (1) · Fluorodeoxyglucose F18 (1) · Interleukin-13 (1) · Paclitaxel (1) · Phantoms, Imaging (1) · TAK-243 (1)
National Cancer Institute (NCI) (3) · Children's Oncology Group (2) · Anusha Kalbasi (1) · City of Hope Medical Center (1) · Mayo Clinic (1) · OHSU Knight Cancer Institute (1) · St. Jude Children's Research Hospital (1)
United States (10) · Australia (1) · Canada (1)
Allison Betof Warner, MD, PhD (1) · Antoni Ribas, MD, PhD (1) · David S Ziegler (1) · Patricia M LoRusso (1) · Sara Federico, MD (1) · Sarah B Whittle (1) · Sarah Shin, MD (1) · Sarina A Piha-Paul (1) · Shivaani Kummar (1) · Vincent Chung, MD (1) · Winston Tan, MD (1) · Yan Xing, MD, PhD (1)
UM1CA228823 (2), P30CA033572 (1), R44CA272064 (1), UM1CA186688 (1), UM1CA186689 (1)