91 completed, 28 terminated, 7 withdrawn, 5 unknown. 73 Phase 2, 53 Phase 1, 18 Not applicable, 5 Phase 3, 1 Early Phase 1.
Follow Recurrent Breast Cancer: new trials by email Literature Review of Recurrent Breast Cancer trials Research Report on Recurrent Breast Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bortezomib Plus Cisplatin in Recurrent or Metastatic Breast Cancer Bortezomib (B), Cisplatin (CDDP) - Metastatic Breast Cancer, Recurrent Breast Cancer | Phase 1 | Recruiting | Sun Yat-sen University | 20 | 2025-01-01 | 2025-04-02 |
| A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer Alisertib, Endocrine therapy - Hormone Receptor Positive HER-2 Negative Breast Cancer, Metastatic Breast Cancer | Phase 2 | Recruiting | Puma Biotechnology, Inc. | 225 | 2024-11-19 | 2026-10-01 |
| A Study of Diffusing Alpha Radiation Therapy for Patients With Breast Carcinoma in Frail or Elderly Patients. Diffusing Alpha Radiation Emitters Therapy (DaRT) - Breast Cancer, Recurrent Breast Cancer | Not applicable | Recruiting | Alpha Tau Medical LTD. | 10 | 2024-02-19 | 2025-02-07 |
| Reoperative Sentinel Lymph Node Biopsy in Patients With Recurrent Ipsilateral Breast Cancer Reoperative Sentinel Lymph Node Biopsy - Recurrent Breast Cancer | Unknown | Hospital Clinic of Barcelona | 97 | 2024-01-01 | 2024-03-25 | |
| A Biomarker Screening Protocol for Participants With Solid Tumors Triple Negative Breast Cancer, Non-small Cell Lung Cancer | Terminated | Lyell Immunopharma, Inc. | 10 | 2023-05-19 | 2025-07-01 | |
| A Study of TQB2930 for Injection Monotherapy or Combination Therapy in Patients With Recurrent/Metastatic Breast Cancer TQB2930 for injection, Paclitaxel for injection (albumin-bound), TQB3616 capsule - Metastatic Breast Cancer, Recurrent Breast Cancer | Phase 1 / Phase 2 | Recruiting | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 154 | 2023-04-13 | 2024-03-12 |
| A Study to Investigate LYL797 in Adults With Solid Tumors LYL797 - Triple Negative Breast Cancer, TNBC - Triple-Negative Breast Cancer | Phase 1 | Terminated | Lyell Immunopharma, Inc. | 57 | 2022-03-29 | 2025-07-01 |
| ONO-4578-06:Phase I Study of ONO-4578 and Letrozole Plus CDK4 /6 Inhibitors in Breast Cancer ONO-4578, letrozole, Palbociclib - Hormone Receptor-positive Breast Cancer, HER2-negative Breast Cancer | Phase 1 | Completed | Ono Pharmaceutical Co., Ltd. | 46 | 2021-11-09 | 2026-06-05 |
| PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer Palbociclib, Avelumab - Triple Negative Breast Cancer, Locally Advanced Breast Cancer | Phase 1 | Active not recruiting | Royal Marsden NHS Foundation Trust | 45 | 2020-08-11 | 2026-08-21 |
| B002 in Patients With HER2-positive Breast Cancer Humanized Anti-HER2 Monoclonal Antibody Compound for Injection .R&D code: B002. - Recurrent Breast Cancer, Metastatic Breast Cancer | Phase 1 | Completed | Shanghai Pharmaceuticals Holding Co., Ltd | 23 | 2019-05-28 | 2023-03-24 |
| ModraDoc006/r in Patients With Breast Cancer ModraDoc006/r - Metastatic Breast Cancer, Recurrent Breast Cancer | Phase 2 | Completed | Modra Pharmaceuticals | 12 | 2019-01-30 | 2021-10-19 |
| T-DM1 and Palbociclib for Metastatic HER2 Breast Cancer Palbociclib, T-DM1 - HER2-positive Breast Cancer, Breast Cancer | Phase 2 | Completed | University of Arizona | 55 | 2018-12-06 | 2024-08-13 |
| Local Treatment in ER-positive/HER2-negative Oligo-metastatic Breast Cancer Surgical resection, Stereotactic body radiotherapy, Radiofrequency ablation - Breast Cancer, Recurrent Breast Cancer | Phase 2 | Unknown | Gangnam Severance Hospital | 110 | 2018-08-01 | 2019-02-15 |
| Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene A166 - HER2-positive Breast Cancer, HER2 Gene Mutation | Phase 1 / Phase 2 | Completed | Klus Pharma Inc. | 49 | 2018-07-16 | 2023-08-03 |
| Abbreviated Breast MRI for Second Breast Cancer Detection in Women With BRCA Mutation Testing Breast Cancer, BRCA1 Mutation | Unknown | Seoul National University Hospital | 1564 | 2018-05-01 | 2020-11-30 | |
| Combination of Trastuzumab and NK Immunotherapy for Recurrent Breast Cancer Trastuzumab, NK immunotherapy - Recurrent Breast Cancer | Phase 1 / Phase 2 | Completed | Fuda Cancer Hospital, Guangzhou | 30 | 2016-07-01 | 2019-09-12 |
| 2nd Line Treatment With Pemetrexed and Sorafenib for Recurrent or Metastatic Triple Negative Breast Cancer Experimental Arm A: Pemetrexed, Experimental Arm A: Sorafenib, Experimental Arm B: Pemetrexed - Breast Cancer, Metastatic Breast Cancer | Phase 2 | Terminated | Virginia Commonwealth University | 13 | 2016-01-28 | 2020-07-14 |
| Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer minocycline hydrochloride, placebo, laboratory biomarker analysis - Anxiety Disorder, Depression | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 56 | 2015-06-23 | 2025-01-08 |
| Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer Taselisib, Trastuzumab emtansine, Pertuzumab - Metastatic Breast Cancer, Recurrent Breast Cancer | Phase 1 | Completed | Nancy Lin, MD | 68 | 2015-04-20 | 2026-09-24 |
| Copper Cu 64-DOTA-Trastuzumab PET in Predicting Response to Treatment With Ado-Trastuzumab Emtansine in Patients With Metastatic HER2 Positive Breast Cancer fludeoxyglucose F 18, positron emission tomography, computed tomography - Bone Metastases, HER2-positive Breast Cancer | Not applicable | Active not recruiting | City of Hope Medical Center | 10 | 2015-01-07 | 2026-02-13 |
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Breast Neoplasms (139) · Breast Neoplasms, Male (52) · Carcinoma, Ovarian Epithelial (15) · Triple Negative Breast Neoplasms (12) · Colonic Neoplasms (10) · Carcinoma, Non-Small-Cell Lung (9) · Rectal Neoplasms (9) · Stomach Neoplasms (9) · Endometrial Neoplasms (7) · Pancreatic Neoplasms (7) · Salivary Gland Neoplasms (7) · Carcinoma, Renal Cell (6) · Fallopian Tube Neoplasms (6) · Prostatic Neoplasms (6) · Uterine Cervical Neoplasms (6)
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Trastuzumab (20) · Taxes (13) · Paclitaxel (10) · Anastrozole (8) · Magnetic Resonance Spectroscopy (8) · Capecitabine (7) · 130-nm albumin-bound paclitaxel (6) · Albumin-Bound Paclitaxel (6) · Carboplatin (6) · Cyclophosphamide (6) · Fulvestrant (6) · Lapatinib (6) · Letrozole (6) · N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl-6-(5-((methylsulfonyl)ethyl)aminomethyl)-2-furyl)-4-quinazolinamine (6) · Vorinostat (6)
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PMID 19153124, PMID 20357034, PMID 22418699, PMID 24170452, PMID 24210070, PMID 25260365, PMID 26059540, PMID 27116183, PMID 27190628, PMID 28045625, PMID 28114604, PMID 28764748, PMID 29233615, PMID 29440043, PMID 30542377, PMID 30846327, PMID 31849532, PMID 32375690, PMID 32641862, PMID 32692450, PMID 33585999, PMID 35429391, PMID 35876391, PMID 36648259, PMID 38236590, PMID 40187749
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