11 completed, 3 active not recruiting, 1 not yet recruiting, 1 recruiting. 8 Phase 1, 5 Not applicable, 3 Phase 2, 1 Early Phase 1, 1 Phase 3.
Follow Recurrent Brain Neoplasm: new trials by email Literature Review of Recurrent Brain Neoplasm trials Research Report on Recurrent Brain Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements Non-Interventional Study - Brain Tumor, Recurrent Brain Tumor | Not yet recruiting | Mayo Clinic | 30 | 2027-06-01 | 2026-09-16 | |
| Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma | Phase 3 | Terminated | NRG Oncology | 19 | 2021-08-05 | 2026-05-20 |
| STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain Laboratory Biomarker Analysis, Pharmacological Study, STAT3 Inhibitor WP1066 - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 8 | 2018-07-13 | 2022-03-23 |
| Blood Brain Barrier Differences in Patients with Brain Tumors Undergoing Surgery Biospecimen Collection, Laboratory Biomarker Analysis - Central Nervous System Neoplasm, Localized Brain Neoplasm | Completed | Mayo Clinic | 54 | 2017-09-20 | 2024-09-27 | |
| Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18) Anti-LAG-3 Monoclonal Antibody BMS 986016, Anti-PD-1, Pharmacological Study - Glioblastoma, Gliosarcoma | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 63 | 2016-08-24 | 2023-10-06 |
| Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors Direct Electrocortical Stimulation, Electrocorticography - Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain | Not applicable | Recruiting | M.D. Anderson Cancer Center | 75 | 2016-07-22 | 2026-05-20 |
| Radiation Therapy in Treating Patients With Recurrent Brain Tumors Who Have Undergone Previous Radiation Therapy Bevacizumab, Quality-of-Life Assessment, Radiation Therapy - Recurrent Brain Neoplasm | Not applicable | Active not recruiting | M.D. Anderson Cancer Center | 40 | 2016-07-20 | 2026-07-15 |
| Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes, Laboratory Biomarker Analysis, Temozolomide - Cytomegalovirus Positive, Glioblastoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 65 | 2016-06-01 | 2023-06-18 |
| Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas Pharmacological Study, Selinexor - Malignant Glioma, Recurrent Brain Neoplasm | Phase 1 | Completed | Children's Oncology Group | 59 | 2015-10-30 | 2025-01-14 |
| Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors Cyclophosphamide, Dasatinib, Laboratory Biomarker Analysis - Advanced Malignant Solid Neoplasm, Recurrent Brain Neoplasm | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 14 | 2015-10-05 | 2026-09-25 |
| EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma EGFRBi-Armed Autologous T Cells, Laboratory Biomarker Analysis - Adult Brain Glioblastoma, Adult Gliosarcoma | Phase 1 / Phase 2 | Withdrawn | Barbara Ann Karmanos Cancer Institute | 2015-08-01 | 2016-02-15 | |
| Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma Biospecimen Collection, Conventional Magnetic Resonance Imaging, Diffusion Tensor Imaging - Constitutional Mismatch Repair Deficiency Syndrome, Lynch Syndrome | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 71 | 2015-06-03 | 2026-07-20 |
| Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme Palliative Radiation Therapy, Questionnaire Administration, Radiation Therapy Treatment Planning and Simulation - Glioblastoma, Recurrent Brain Neoplasm | Not applicable | Completed | Jonsson Comprehensive Cancer Center | 10 | 2014-11-12 | 2019-02-28 |
| Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy Cognitive Assessment, Computer-Assisted Cognitive Training, Psychosocial Assessment and Care - Brain Neoplasm, Recurrent Brain Neoplasm | Not applicable | Completed | Children's Oncology Group | 45 | 2014-07-30 | 2026-08-28 |
| 18F-DOPA-PET in Planning Surgery in Patients With Gliomas Biopsy, Computed Tomography, Diffusion Weighted Imaging - Malignant Glioma, Recurrent Brain Neoplasm | Early Phase 1 | Completed | Mayo Clinic | 72 | 2014-01-22 | 2025-01-23 |
| 18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors Computed Tomography, Fluorothymidine F-18, Positron Emission Tomography - Metastatic Malignant Neoplasm in the Brain, Primary Brain Neoplasm | Not applicable | Completed | University of Washington | 9 | 2012-11-01 | 2020-01-13 |
| Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma Laboratory Biomarker Analysis, Montanide ISA-51/Survivin Peptide Vaccine, Sargramostim - Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma | Phase 1 | Completed | Roswell Park Cancer Institute | 9 | 2012-09-05 | 2017-02-27 |
| Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors Bevacizumab, Laboratory Biomarker Analysis, Pharmacological Study - Giant Cell Glioblastoma, Glioblastoma | Phase 2 | Completed | National Cancer Institute (NCI) | 137 | 2012-06-04 | 2022-07-21 |
Brain Neoplasms (18) · Glioblastoma (6) · Glioma (6) · Gliosarcoma (5) · Astrocytoma (2) · Central Nervous System Neoplasms (2) · Melanoma (2) · Oligodendroglioma (2) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Renal Cell (1) · Colorectal Neoplasms, Hereditary Nonpolyposis (1) · Diffuse Intrinsic Pontine Glioma (1) · Ependymoma (1) · Familial ependymoma (1)
Brain Diseases (18) · Central Nervous System Diseases (18) · Neoplasms (18) · Neoplasms by Site (18) · Nervous System Diseases (18) · Nervous System Neoplasms (18) · Central Nervous System Neoplasms (16) · Neoplasms by Histologic Type (11) · Neoplasms, Germ Cell and Embryonal (11) · Neoplasms, Glandular and Epithelial (11) · Neoplasms, Nerve Tissue (11) · Neuroectodermal Tumors (11) · Neoplasms, Neuroepithelial (10) · Astrocytoma (5) · Glioma (4)
Magnetic Resonance Spectroscopy (4) · Specimen Handling (3) · Bevacizumab (2) · Disulfides (2) · Immunoglobulin G (2) · Biopsy (1) · Colony-Stimulating Factors (1) · Cyclophosphamide (1) · Dasatinib (1) · Diffusion Tensor Imaging (1) · Memantine (1) · Mental Status and Dementia Tests (1) · Nivolumab (1) · Psychiatric Rehabilitation (1) · Radiation (1)
M.D. Anderson Cancer Center (5) · Mayo Clinic (3) · Children's Oncology Group (2) · National Cancer Institute (NCI) (2) · Barbara Ann Karmanos Cancer Institute (1) · Jonsson Comprehensive Cancer Center (1) · NRG Oncology (1) · Roswell Park Cancer Institute (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · University of Washington (1)
United States (17) · Canada (4) · Hong Kong (1)
Alfredo Quinones-Hinojosa, MD (1) · Amy B Heimberger (1) · Debra H. Brinkmann, Ph.D. (1) · Eudocia Q Lee (1) · Eugene I Hwang (1) · Jann N. Sarkaria, M.D. (1) · Jason Rockhill (1) · Julia Glade-Bender (1) · Kristina K Hardy (1) · Micheal Lim, MD (1) · Nadia N. Laack, M.D. (1) · Robert Fenstermaker (1) · Sandeep Mittal (1) · Shiao-Pei Weathers (1) · Sujit S Prabhu (1)
PMID 32154928, PMID 37590001, PMID 39998852, PMID 42432293
U10CA180868 (2), P01CA042045 (1), P30CA015704 (1), P30CA016042 (1), P30CA016056 (1), P30CA016672 (1), P30CA022453 (1), P50CA093459 (1), P50CA108961 (1), P50CA127001 (1), R01CA178200 (1), U10CA021661 (1), U10CA095861 (1), U54CA210180 (1), UG1CA189955 (1)