5 completed, 4 recruiting, 2 enrolling by invitation, 2 unknown. 4 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 1, Enrolling by invitation 1, Recruiting 1, Unknown 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Radiologically Isolated Syndrome: new trials by email Literature Review of Radiologically Isolated Syndrome trials Research Report on Radiologically Isolated Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Impact Through AI-assisted MS Care - A Prospective Multi-center Study quantitative brain MRI (icobrain mr), Standard of Care (SOC) - Multiple Sclerosis, Radiologically Isolated Syndrome | Not applicable | Enrolling by invitation | icometrix | 750 | 2025-10-09 | 2025-12-09 |
| Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid. Observational - Radiologically Isolated Syndrome, Multiple Sclerosis | Completed | Centre Hospitalier Universitaire de Nīmes | 320 | 2024-04-15 | 2026-06-01 | |
| Clinical Impact Through AI-assisted MS Care - A Retrospective Multi-center Observational Study. Multiple Sclerosis, NMO Spectrum Disorder | Recruiting | icometrix | 7000 | 2024-03-01 | 2025-12-12 | |
| Environmental Risk Factors in Multiple Sclerosis Development: Epidemiological Study of EBV Infection and Vitamin D Deficiency in RIS Patients Antibiody titration - Radiologically Isolated Syndrome, Epstein-Barr Virus Infections | Completed | Centre Hospitalier Universitaire de Nīmes | 110 | 2023-08-01 | 2025-12-01 | |
| Diagnostic Value of eVOG eVOG - Multiple Sclerosis, Radiologically Isolated Syndrome | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nice | 150 | 2023-04-07 | 2026-06-16 |
| Epstein Barr Virus Infection in Patients With Radiologically Isolated Syndrome NO INTERVENTION - Multiple Sclerosis, Radiologically Isolated Syndrome | Completed | Centre Hospitalier Universitaire de Nice | 156 | 2023-03-15 | 2025-05-08 | |
| RIS International Cohort No intervention - Multiple Sclerosis, Radiologically Isolated Syndrome | Recruiting | Centre Hospitalier Universitaire de Nice | 1000 | 2022-04-15 | 2022-05-24 | |
| Ocrelizumab for Preventing Clinical Multiple Sclerosis in Individuals With Radiologically Isolated Disease. Ocrelizumab, Placebo - Radiologically Isolated Syndrome, Multiple Sclerosis | Phase 4 | Terminated | Yale University | 3 | 2022-02-15 | 2024-10-09 |
| MS-ResearchBiomarkerS Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting | Recruiting | Cedars-Sinai Medical Center | 1000 | 2021-11-11 | 2024-02-06 | |
| Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated Syndrome Tear collection and lumbar punction - Clinically Isolated Syndrome, Radiologically Isolated Syndrome | Not applicable | Unknown | Lille Catholic University | 20 | 2019-09-26 | 2023-09-13 |
| Risk Factors in Early Multiple Sclerosis Brain MRI - Multiple Sclerosis, Magnetic Resonance Imaging | Unknown | University of Colorado, Denver | 300 | 2018-07-26 | 2023-02-06 | |
| Prognostic Value of Three New Biomarkers of Multiple Sclerosis in Patients With Radiologically Isolated Syndrome Analysis of cerebrospinal fluid and serum - Multiple Sclerosis, Radiologically Isolated Syndrome | Completed | Centre Hospitalier Universitaire de Nīmes | 100 | 2018-07-01 | 2025-12-01 | |
| Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography Video-oculography / Social cognition tasks / Neuropsychological evaluations - Multiple Sclerosis (MS), Multiple Sclerosis (MS) Relapsing Remitting | Not applicable | Completed | Association de Recherche Bibliographique pour les Neurosciences | 76 | 2017-05-23 | 2021-01-22 |
| The Italian Multiple Sclerosis and Related Disorders Register Multiple Sclerosis, Neuromyelitis Optica | Enrolling by invitation | Fondazione Italiana Sclerosi Multipla | 96000 | 2014-09-17 | 2026-06-09 |
Multiple Sclerosis (13) · Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (3) · Neuromyelitis Optica (3) · Demyelinating Diseases (2) · Epstein-Barr Virus Infections (2) · Multiple Sclerosis, Chronic Progressive (2) · Multiple Sclerosis, Relapsing-Remitting (2) · Autoimmune Diseases (1) · Autoimmune Diseases of the Nervous System (1) · Disease Progression (1) · Nerve Degeneration (1) · Nervous System Diseases (1)
Demyelinating Autoimmune Diseases, CNS (13) · Immune System Diseases (13) · Autoimmune Diseases (12) · Autoimmune Diseases of the Nervous System (12) · Nervous System Diseases (12) · Demyelinating Diseases (11) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Cranial Nerve Diseases (3) · Disease Attributes (3) · Eye Diseases (3) · Myelitis, Transverse (3) · Optic Nerve Diseases (3) · Optic Neuritis (3) · Chronic Disease (2)
Hematologic Tests (1) · Standard of Care (1) · Watchful Waiting (1) · ocrelizumab (1)
Centre Hospitalier Universitaire de Nice (3) · Centre Hospitalier Universitaire de Nīmes (3) · icometrix (2) · Association de Recherche Bibliographique pour les Neurosciences (1) · Cedars-Sinai Medical Center (1) · Fondazione Italiana Sclerosi Multipla (1) · Lille Catholic University (1) · University of Colorado, Denver (1) · Yale University (1)
France (7) · United States (4) · Czechia (2) · Germany (2) · Italy (2) · Monaco (1)
Eric Thouvenot (2) · Brooke Guerrero, MD (1) · Friedemann Paul, PhD, MD (1) · Hautecoeur Patrick (1) · John R Corboy, MD (1) · Laura Locke, CRNP (1) · Marwa Kaisey, MD (1) · Nancy Sicotte, MD (1) · Omar Al-Louzi, MD (1) · Pascal Sati, PhD (1)
PMID 29564952, PMID 30426289, PMID 36031693, PMID 37311951, PMID 39329242, PMID 41841206