303 completed, 83 recruiting, 69 active not recruiting, 60 terminated. 600 Phase 3, 77 Phase 2.
Follow Prostatic Neoplasms: new trials by email Literature Review of Prostatic Neoplasms trials Research Report on Prostatic Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Use of High Dose Testosterone Followed by Darolutamide Compared to the Usual Care for Patients With Metastatic Prostate Cancer Abiraterone Acetate, Biospecimen Collection, Bone Scan - Metastatic Castration-Resistant Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 / Phase 3 | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 432 | 2027-01-06 | 2026-10-01 |
| Best Salvage Treatment for High-risk Relapsing Prostate Cancer (PEACE-9 - ESCALATE-RT) Radiotherapy for MDT ± WPRT, Androgen Deprivation Therapy (ADT), Enzalutamide - Prostatic Neoplasms, Biochemical Recurrence | Phase 3 | Not yet recruiting | Ente Ospedaliero Cantonale, Bellinzona | 140 | 2026-11-01 | 2026-08-24 |
| A Study of JNJ-101556143 With Best Supportive Care in Participants With Metastatic Prostate Cancer JNJ-101556143, Placebo, Best Supportive Care - Prostatic Neoplasms | Phase 3 | Recruiting | Janssen Research & Development, LLC | 400 | 2026-10-29 | 2026-11-03 |
| ADT De-escalation in Selected High-Risk Prostate Cancer Patients (ADaPPt Trial) a GROUQ Led PCS Study (PCS XIV) ZOLADEX 10.8 mg - High Risk Prostate Cancer | Phase 3 | Not yet recruiting | Dr. Tamim Niazi | 600 | 2026-10-01 | 2026-08-20 |
| Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer ultiparametric Magnetic Resonance Imaging, Perflutren lipid microsphere, Transrectal Ultrasound - Prostate Carcinoma | Phase 3 | Not yet recruiting | Thomas Jefferson University | 300 | 2026-10-01 | 2026-08-25 |
| Dose Optimization and Diagnostic Performance in Prostate Cancer (SPARROW [Staging Prostate Cancer With Advanced RM2 Radiotracer Oncologic Workup]) [68Ga]-LNTH-2401 - Prostate Cancer | Phase 2 / Phase 3 | Recruiting | Lantheus Medical Imaging | 408 | 2026-09-30 | 2026-09-21 |
| Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05) Saruparib, Placebo, Enzalutamide - Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) | Phase 3 | Recruiting | AstraZeneca | 1330 | 2026-09-15 | 2026-10-15 |
| A Study of Risvutatug Rezetecan in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) [EMBOLD Prostate-302] Risvutatug rezetecan (Ris-Rez), Enzalutamide, Abiraterone - Neoplasms, Prostate | Phase 3 | Recruiting | GlaxoSmithKline | 684 | 2026-09-01 | 2026-10-02 |
| RIsk aDapted Stereotactic Radiotherapy vs. standarD of Care Radiotherapy in Patients With Prostate Cancer in the Adjuvant or saLvage sEtting With or Without Lymph Node Irradiation (RIDDLELN) - A Phase III Trial Stereotactic body radiotherapy (SBRT) to the prostate bed, Standard-of-care radiotherapy (SOC) to the prostate bed - Prostate Cancer (Post Prostatectomy), Prostate Cancer | Phase 3 | Not yet recruiting | Robert Förster | 206 | 2026-09-01 | 2026-09-21 |
| Carboplatin-Enhanced Therapy in BRCA-Mutated or Neuroendocrine-Differentiated Aggressive Metastatic Castration-Sensitive Prostate Cancer Experimental - BRCA-Mutated, Neuroendocrine-Differentiated Aggressive Metastatic Castration-Sensitive Prostate Cancer | Phase 3 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 330 | 2026-09-01 | 2026-05-15 |
| Study to Evaluate the Efficacy and Safety of 177Lu-NYM032 Injection in Participants With Progressive, PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC) 177Lu-NYM032 injection, Best supportive/best standard of care - Prostate Cancer | Phase 3 | Not yet recruiting | Norroy Bioscience Co., LTD | 600 | 2026-08-31 | 2026-08-31 |
| This Study Evaluates the Diagnostic Performance and Safety of 68Ga-NYM032 PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer. 68-Ga-NYM032 - Prostate Cancer | Phase 3 | Recruiting | Norroy Bioscience Co., LTD | 232 | 2026-08-31 | 2026-09-15 |
| Evaluating Hormone Therapy to Achieve Optimal Doses in Metastatic Prostate Cancer Abiraterone, Apalutamide, Enzalutamide or Darolutamide (ARPI therapy) (per standard of care) therapy - Prostate Cancer, mHSPC | Phase 3 | Recruiting | University College, London | 1500 | 2026-08-28 | 2026-11-04 |
| Investigating the Safety and Diagnostic Performance of 68Ga-NYM032 Injection PET/CT in Men With Newly Diagnosed Prostate Cancer. 68-Ga-NYM032 - Prostate Cancer (Diagnosis) | Phase 3 | Recruiting | Norroy Bioscience Co., LTD | 365 | 2026-08-06 | 2026-08-17 |
| A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1) Rinzimetostat, Darolutamide, Enzalutamide - Metastatic Castration Resistant Prostate Cancer | Phase 3 | Recruiting | ORIC Pharmaceuticals | 600 | 2026-08-03 | 2026-11-03 |
| Long-Term Extension Study for Participants Previously Enrolled in an Exelixis-Sponsored Study Cabozantinib, Zanzalintinib, Atezolizumab - Cancer, Renal Cell Carcinoma (RCC) | Phase 3 | Enrolling by invitation | Exelixis | 5000 | 2026-07-30 | 2026-10-28 |
| QLC5508 in Participants With Metastatic Prostate Cancer QLC5508, Docetaxel - Prostate Cancer | Phase 3 | Not yet recruiting | Qilu Pharmaceutical Co., Ltd. | 700 | 2026-06-20 | 2026-06-08 |
| Phase III Randomized International Open Label Clinical Trial of Treatment Intensification With Docetaxel Plus Apalutamide in Patients With Metastatic Hormone-sensitive Prostate Cancer Who Did Not Achieve a Deep PSA Response After Initial Treatment With Apalutamide: REINFORCE Trial. Apalutamide (Erleada™) 60 mg or 240 mg tablets, Docetaxel - Metastatic Hormone-sensitive Prostate Cancer | Phase 3 | Recruiting | Alianza multidisciplinar para la investigación de los tumores genitourinarios -GUARD | 320 | 2026-06-05 | 2026-06-17 |
| Comparative Analysis of Immunological Responses to Vitamin D Replacement Therapy in Black and West African Men Diagnosed With Prostate Cancer: Elucidating Differential Effects on Immune Function Between Patients With Localized Disease and Those With Metastatic Progression vitamin D 25(OH)D - Prostate Cancer (Adenocarcinoma), Vitamin D on Tumor Response and Inflammatory Markers | Phase 3 | Not yet recruiting | University of Ilorin Teaching Hospital | 200 | 2026-06-01 | 2026-05-20 |
| AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01) Actinium (225Ac) zadavotide guraxetan (AZD2265 [FPI-2265]), Cabazitaxel, Abiraterone - Metastatic Castration-resistant Prostate Cancer | Phase 3 | Recruiting | AstraZeneca | 670 | 2026-05-04 | 2026-10-19 |
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Neoplasms (41) · Neoplasm Metastasis (28) · Breast Neoplasms (22) · Pain (13) · Lung Neoplasms (12) · Prostatic Neoplasms, Castration-Resistant (10) · Osteoporosis (9) · Colorectal Neoplasms (8) · Ovarian Neoplasms (8) · Adenocarcinoma (7) · Carcinoma, Non-Small-Cell Lung (7) · Colonic Neoplasms (7) · Disease (7) · Erectile Dysfunction (7)
Genital Diseases (599) · Urogenital Diseases (599) · Genital Diseases, Male (597) · Male Urogenital Diseases (596) · Neoplasms by Site (596) · Prostatic Diseases (596) · Genital Neoplasms, Male (595) · Urogenital Neoplasms (594) · Neoplasms (559) · Pathological Conditions, Signs and Symptoms (69) · Pathologic Processes (46) · Neoplastic Processes (29) · Female Urogenital Diseases (28) · Female Urogenital Diseases and Pregnancy Complications (28) · Signs and Symptoms (28)
Prednisone (64) · Docetaxel (62) · Radiotherapy (55) · Goserelin (52) · Leuprolide (52) · bicalutamide (48) · enzalutamide (41) · Androgen Antagonists (34) · acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide (33) · Flutamide (26) · Triptorelin Pamoate (26) · Abiraterone Acetate (24) · abiraterone (22) · apalutamide (21) · Gonadotropin-Releasing Hormone (18)
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