19 completed, 3 terminated, 1 active not recruiting, 1 unknown. 11 Phase 1, 8 Phase 2, 4 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 9, Terminated 1, Unknown 1 |
| Phase 2 | 8 | Completed 4, Terminated 3, Active not recruiting 1 |
| Not applicable | 4 | Completed 3, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Plasma Cell Neoplasm: new trials by email Literature Review of Plasma Cell Neoplasm trials Research Report on Plasma Cell Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase II Study of Salvage Radiation Treatment After B-cell Maturation Antigen Chimeric Antigen Receptor T-cell Therapy for Relapsed Refractory Multiple Myeloma Radiation Therapy - Multiple Myeloma, Plasma Cell Neoplasm | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 30 | 2022-05-31 | 2026-10-06 |
| COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies Dose escalation: COM902 monotherapy., Evaluation of safety/tolerability: COM902 in combination with COM701 (both at the RDFE), Cohort expansion: COM902 (RDFE) monotherapy. - Advanced Cancer, Ovarian Cancer | Phase 1 | Completed | Compugen Ltd | 94 | 2020-03-31 | 2026-08-12 |
| Influenza Vaccination for Flu Prevention in Patients With Plasma Cell Disorders Pneumococcal 13-valent Conjugate Vaccine, Trivalent Influenza Vaccine - Plasma Cell Neoplasm | Phase 4 | Completed | Emory University | 165 | 2019-10-18 | 2025-02-28 |
| A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies Autologous chimeric antigen receptor T cell transfusing agent targeting CD22 - Diffuse Large B Cell Lymphoma, Follicular Lymphoma | Phase 1 | Unknown | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | 10 | 2018-12-01 | 2019-06-27 |
| Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies Fludarabine, Cyclophosphamide, Total body irradiation - Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 117 | 2015-12-01 | 2022-11-03 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia cefepime hydrochloride - Adult Acute Lymphoblastic Leukemia, Adult Acute Myeloid Leukemia | Phase 1 | Completed | Wake Forest University Health Sciences | 70 | 2011-02-01 | 2018-07-18 |
| A Study Evaluating the Effects of Siltuximab on the Heart in Patients With Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Indolent Multiple Myeloma Siltuximab - Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma | Phase 1 | Completed | Janssen Research & Development, LLC | 30 | 2010-10-01 | 2015-01-19 |
| Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy sunitinib malate, pharmacological study, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2009-08-01 | 2014-03-17 |
| Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Cord Blood Transplant for Hematologic Malignancy human myeloid progenitor cells - Leukemia, Lymphoma | Phase 1 | Completed | Cellerant Therapeutics | 30 | 2009-04-01 | 2014-10-27 |
| Lenalidomide and Low-Dose Dexamethasone in Patients With Previously Treated Multiple Myeloma and Kidney Dysfunction Lenalidomide, Dexamethasone, Anticoagulants - Multiple Myeloma, Plasma Cell Neoplasm | Phase 1 / Phase 2 | Terminated | PrECOG, LLC. | 63 | 2009-01-21 | 2018-10-24 |
| S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases assessment of therapy complications - Breast Cancer, Lung Cancer | Completed | SWOG Cancer Research Network | 3571 | 2008-12-01 | 2019-07-05 | |
| Biomarkers Related to Thrombosis in Patients With Newly Diagnosed Multiple Myeloma Receiving Chemotherapy enzyme-linked immunosorbent assay, laboratory biomarker analysis, medical chart review - Multiple Myeloma, Plasma Cell Neoplasm | Completed | UNC Lineberger Comprehensive Cancer Center | 18 | 2008-12-01 | 2016-08-22 | |
| Vorinostat and Lenalidomide After Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma lenalidomide, vorinostat - Multiple Myeloma, Plasma Cell Neoplasm | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 19 | 2008-09-26 | 2020-05-18 |
| Human Immune Globulin in Treating Patients With Primary Amyloidosis That is Causing Heart Dysfunction Human immune globulin intravenous (IGIV) - Multiple Myeloma, Plasma Cell Neoplasm | Phase 1 / Phase 2 | Completed | University of Tennessee | 10 | 2007-10-01 | 2013-09-19 |
| T-Regulatory Cell Infusion Post Umbilical Cord Blood Transplant in Patients With Advanced Hematologic Cancer umbilical cord blood transplantation, Allopurinol, fludarabine phosphate - Leukemia, Lymphoma | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 41 | 2007-07-23 | 2017-12-02 |
| High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors etoposide, cyclophosphamide, carmustine - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Not applicable | Completed | Roswell Park Cancer Institute | 174 | 2006-06-29 | 2021-04-22 |
| S0232 Dexamethasone With or Without Lenalidomide in Treating Patients With Previously Untreated Stage I, Stage II, or Stage III Multiple Myeloma dexamethasone, lenalidomide, placebo - Multiple Myeloma, Plasma Cell Neoplasm | Phase 3 | Completed | SWOG Cancer Research Network | 198 | 2004-11-01 | 2015-03-25 |
| Epoetin Alfa in Treating Anemia in Patients Undergoing Chemotherapy for Multiple Myeloma epoetin alfa - Anemia, Multiple Myeloma | Not applicable | Completed | The Cleveland Clinic | 31 | 2003-09-01 | 2018-02-22 |
| Ice Chips or Saline Mouth Rinse in Reducing or Preventing Mucositis in Patients Receiving Melphalan and Autologous Stem Cell Transplant for Multiple Myeloma chemoprotection, complementary or alternative medicine procedure, management of therapy complications - Multiple Myeloma, Plasma Cell Neoplasm | Not applicable | Completed | Fred Hutchinson Cancer Center | 41 | 2003-07-01 | 2011-09-01 |
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Neoplasms, Plasma Cell (25) · Multiple Myeloma (22) · Leukemia, Lymphocytic, Chronic, B-Cell (8) · Lymphoma, Follicular (8) · Lymphoma, Large B-Cell, Diffuse (8) · Leukemia, Prolymphocytic (7) · Lymphoma, B-Cell, Marginal Zone (7) · Lymphoma, Mantle-Cell (7) · Burkitt Lymphoma (6) · Hodgkin Disease (6) · Lymphoma, Large-Cell, Immunoblastic (6) · Myelodysplastic Syndromes (6) · Congenital Abnormalities (5) · Leukemia, Myeloid, Acute (5) · Lymphoma, Non-Hodgkin (5)
Neoplasms (25) · Neoplasms by Histologic Type (25) · Hemic and Lymphatic Diseases (24) · Immune System Diseases (24) · Immunoproliferative Disorders (24) · Lymphoproliferative Disorders (24) · Hematologic Diseases (23) · Blood Protein Disorders (22) · Cardiovascular Diseases (22) · Hemorrhagic Disorders (22) · Hemostatic Disorders (22) · Vascular Diseases (22) · Paraproteinemias (21) · Lymphatic Diseases (10) · Pathologic Processes (9)
Cyclophosphamide (5) · fludarabine phosphate (5) · Filgrastim (4) · Granulocyte Colony-Stimulating Factor (4) · Melphalan (4) · Whole-Body Irradiation (4) · Lenalidomide (3) · Mycophenolic Acid (3) · Tacrolimus (3) · Allopurinol (2) · Antilymphocyte Serum (2) · Busulfan (2) · Dexamethasone (2) · Methotrexate (2) · fludarabine (2)
Alliance for Clinical Trials in Oncology (2) · Masonic Cancer Center, University of Minnesota (2) · Roswell Park Cancer Institute (2) · SWOG Cancer Research Network (2) · Boston Medical Center (1) · Cellerant Therapeutics (1) · Compugen Ltd (1) · Emory University (1) · Fred Hutchinson Cancer Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Janssen Research & Development, LLC (1) · M.D. Anderson Cancer Center (1) · National Cancer Institute (NCI) (1) · Ohio State University Comprehensive Cancer Center (1) · PersonGen BioTherapeutics (Suzhou) Co., Ltd. (1)
United States (23) · Belgium (1) · China (1) · Mexico (1) · Russia (1) · Saudi Arabia (1)
Philip McCarthy (2) · Alan Solomon, MD (1) · Amy E DeZern, MD (1) · Asad Bashey, MD, PhD (1) · Catherine Van Poznak, MD (1) · Claudio G. Brunstein, MD, PhD (1) · Craig Hofmeister, MD, MPH (1) · Daniel M. Sullivan, M.D. (1) · Erica Warlick, MD (1) · Jeffrey A. Zonder, MD (1) · John Deeken (1) · John E Wagner, MD (1) · John Williamson (1)
PMID 19179301, PMID 20674758, PMID 20876454, PMID 20952687, PMID 21403127, PMID 22259028, PMID 22430088, PMID 24474568, PMID 26058589, PMID 27928641, PMID 30190454, PMID 32325171
U10CA031946 (2), P01CA015396 (1), P30CA016056 (1), P30CA016086 (1), P30CA043703 (1), P30CA138292 (1), U01CA121947 (1), U10CA032102 (1), U10CA037429 (1)