4 terminated, 3 active not recruiting, 2 recruiting, 1 completed. 4 Phase 2, 3 Phase 1, 1 Not applicable, 1 Phase 4.
Follow Pilocytic Astrocytoma: new trials by email Literature Review of Pilocytic Astrocytoma trials Research Report on Pilocytic Astrocytoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach Amygdalo-Hippocampectomy - Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor | Recruiting | University Hospital, Montpellier | 3504 | 2024-08-31 | 2025-04-08 | |
| Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors Anaplastic Astrocytoma, Diffuse Brainstem Glioma | Terminated | Pediatric Brain Tumor Consortium | 57 | 2023-07-12 | 2026-04-23 | |
| Tovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid Tumors Tovorafenib, Tovorafenib Drug: Pimasertib - Melanoma, Solid Tumor | Phase 1 | Terminated | Day One Biopharmaceuticals, Inc. | 44 | 2022-05-02 | 2025-08-14 |
| Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors Tovorafenib - Melanoma, Solid Tumor | Phase 2 | Terminated | Day One Biopharmaceuticals, Inc. | 23 | 2021-07-15 | 2025-10-02 |
| Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms ONC206 - Central Nervous System Neoplasms, Glioblastoma | Phase 1 | Recruiting | Jazz Pharmaceuticals | 102 | 2020-10-26 | 2026-10-23 |
| Pediatric Long-Term Follow-up and Rollover Study dabrafenib, trametinib - Diffuse Astrocytoma, Anaplastic Astrocytoma | Phase 4 | Active not recruiting | Novartis Pharmaceuticals | 163 | 2019-11-04 | 2026-08-27 |
| Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma Hippocampal-avoidance proton therapy - Glioma, Pilocytic Astrocytoma | Not applicable | Active not recruiting | St. Jude Children's Research Hospital | 48 | 2019-08-28 | 2026-09-15 |
| Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors Dabrafenib, trametinib, Carboplatin - Diffuse Astrocytoma, Anaplastic Astrocytoma | Phase 2 | Completed | Novartis Pharmaceuticals | 151 | 2017-12-28 | 2023-12-13 |
| Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors MRI-guided laser ablation, Doxorubicin, Etoposide - Glioma, Pilocytic Astrocytoma | Phase 2 | Terminated | Washington University School of Medicine | 6 | 2015-08-14 | 2024-11-01 |
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Mebendazole, Vincristine, Carboplatin - Pilomyxoid Astrocytoma, Pilocytic Astrocytoma | Phase 1 / Phase 2 | Active not recruiting | Julie Krystal | 10 | 2013-10-22 | 2026-08-06 |
Astrocytoma (10) · Glioblastoma (6) · Glioma (6) · Oligodendroglioma (5) · Ganglioglioma (4) · Carcinoma, Non-Small-Cell Lung (2) · Central Nervous System Neoplasms (2) · Colorectal Neoplasms (2) · Ependymoma (2) · Ganglioneuroma (2) · Gliosarcoma (2) · Medulloblastoma (2) · Melanoma (2) · Neurocytoma (2) · Optic Nerve Glioma (2)
Neoplasms (10) · Neoplasms by Histologic Type (10) · Neoplasms, Germ Cell and Embryonal (10) · Neoplasms, Glandular and Epithelial (10) · Neoplasms, Nerve Tissue (10) · Neoplasms, Neuroepithelial (9) · Neuroectodermal Tumors (9) · Neoplasms by Site (8) · Nervous System Diseases (7) · Nervous System Neoplasms (6) · Brain Diseases (5) · Central Nervous System Diseases (5) · Brain Neoplasms (4) · Glioma (4) · Central Nervous System Neoplasms (3)
Carboplatin (2) · Vincristine (2) · dabrafenib (2) · tovorafenib (2) · trametinib (2) · Bevacizumab (1) · Doxorubicin (1) · Dynamic Contrast Enhanced Magnetic Resonance Imaging (1) · Etoposide (1) · Irinotecan (1) · Mebendazole (1) · ONC206 (1) · Perfusion Magnetic Resonance Imaging (1) · Temozolomide (1) · etoposide phosphate (1)
Day One Biopharmaceuticals, Inc. (2) · Novartis Pharmaceuticals (2) · Jazz Pharmaceuticals (1) · Julie Krystal (1) · Pediatric Brain Tumor Consortium (1) · St. Jude Children's Research Hospital (1) · University Hospital, Montpellier (1) · Washington University School of Medicine (1)
United States (9) · Canada (5) · France (4) · Australia (3) · Belgium (3) · Spain (3) · Argentina (2) · Brazil (2) · Czechia (2) · Denmark (2) · Finland (2) · Germany (2) · Israel (2) · Italy (2) · Japan (2)
Alexandra Miller, MD, PhD (1) · Andrew Cluster, M.D. (1) · Julie Krystal, MD (1) · Thomas Merchant, MD (1)
PMID 34331515, PMID 35417530, PMID 37610803, PMID 37643378, PMID 37733309, PMID 41740060, PMID 42826365
2015 (1), 2023 (1), UM1CA081457 (1)