14 completed, 4 terminated, 3 unknown, 2 recruiting. 7 Phase 2, 6 Phase 3, 3 Not applicable, 2 Early Phase 1, 2 Phase 1.
Follow Paraparesis, Tropical Spastic: new trials by email Literature Review of Paraparesis, Tropical Spastic trials Research Report on Paraparesis, Tropical Spastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dolutegravir Versus Dolutegravir in Combination With Tenofovir for the Treatment of HTLV-1 Infection Combination of Dolutegravir + Tenofovir DF for treatment of HTLV-1 infection, Dolutegravir (DTG) - HTLV-1 Infection, HTLV I Associated Myelopathies | Phase 2 | Recruiting | Carlos Brites | 146 | 2026-05-07 | 2026-06-02 |
| A Clinical Pharmacological Study of MT-3921 in Subjects With HTLV-1 Associated Myelopathy (HAM) MT-3921, Placebo - HTLV-1-Associated Myelopathy (HAM) | Phase 1 | Completed | Tanabe Pharma Corporation | 15 | 2022-05-02 | 2024-01-29 |
| Rehabilitation in Patients With Human Lymphotropic Virus Type I Inspiratory muscle trainning, Exercise - Human T-Lymphotropic Virus Type 1 Associated Myelopathy | Not applicable | Unknown | Universidade Metodista de Piracicaba | 40 | 2021-04-27 | 2021-05-06 |
| Rituximab for HTLV-1-associated Myelopathy Rituximab - HTLV-1-associated Myelopathy | Phase 2 | Unknown | First Affiliated Hospital of Fujian Medical University | 100 | 2019-08-15 | 2022-04-19 |
| MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study MP Diagnostics HTLV Blot 2.4 - HTLV-I Infections, HTLV-II Infections | Phase 4 | Completed | MP Biomedicals, LLC | 150 | 2018-01-15 | 2018-09-13 |
| Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection "Raltegravir" and "Zidovudine" - HTLV-I Infections, Tropical Spastic Paraparesis | Early Phase 1 | Completed | Universidad Peruana Cayetano Heredia | 10 | 2017-07-01 | 2019-05-22 |
| A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) KW-0761 0.3 mg/kg IV, Placebo (saline) - HTLV-1 Associated Myelopathy | Phase 3 | Terminated | Kyowa Kirin Co., Ltd. | 66 | 2017-05-22 | 2022-04-14 |
| Dual Algorithm Post Market Clinical Study MP Diagnostics HTLV Blot 2.4 - HTLV-I Infections, HTLV-II Infections | Completed | MP Biomedicals, LLC | 100 | 2017-03-01 | 2017-06-12 | |
| Raltegravir for HAM/TSP Raltegravir - HTLV-I Infection | Early Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 19 | 2013-09-05 | 2023-03-30 |
| Urological Physical Therapy in HTLV-1 With Urinary Symptoms Urological physical therapy - Tropical Spastic Paraparesis, HTLV-1 | Not applicable | Completed | Hospital Universitário Professor Edgard Santos | 20 | 2012-03-01 | 2018-10-05 |
| Evaluation of the MP Diagnostics HTLV Blot 2.4 CDPHL Algorithm - HTLV-I Infections, HTLV-II Infections | Unknown | MP Biomedicals, LLC | 600 | 2011-11-01 | 2011-11-08 | |
| Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Tamibarotene - HTLV-I-Associated Myelopathy | Phase 2 / Phase 3 | Terminated | St. Marianna University School of Medicine | 15 | 2011-01-01 | 2026-10-08 |
| Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Pentoxifylline, Placebo - HTLV-1, Tropical Spastic Paraparesis | Phase 3 | Completed | Hospital Universitário Professor Edgard Santos | 48 | 2009-09-01 | 2015-03-18 |
| The HAM Infliximab Study Infliximab - HTLV-I-associated Myelopathy | Phase 2 | Terminated | Imperial College London | 3 | 2008-10-01 | 2013-04-15 |
| Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Valproic acid, costicosteroids, valproid acid plus corticosteroids - Paraparesis Spastic Tropical | Phase 3 | Completed | University of Sao Paulo | 60 | 2008-02-01 | 2015-12-03 |
| Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) ciclosporin - HTLV I Associated Myelopathy | Phase 2 / Phase 3 | Completed | Imperial College London | 7 | 2006-08-01 | 2021-09-09 |
| Safety and Efficiency Study of Valproic Acid In HAM/TSP Valproic Acid - HTLV-I-Associated Myelopathy | Not applicable | Terminated | University Hospital Pierre Zobda-Quitman | 19 | 2006-03-01 | 2007-08-22 |
| Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Hu MiK-Beta-1 - HTLV-1 | Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 9 | 2004-02-03 | 2019-06-27 |
| MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Tropical Spastic Paraparesis | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2002-04-01 | 2008-03-04 | |
| Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Zidovudine/lamivudine, Placebos - HTLV-I-associated Myelopathy | Phase 2 / Phase 3 | Completed | Imperial College London | 16 | 1999-11-08 | 2021-08-25 |
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HTLV-I Infections (9) · Leukemia-Lymphoma, Adult T-Cell (4) · HTLV-II Infections (3) · Epstein-Barr Virus Infections (1) · Herpesviridae Infections (1) · Immune System Diseases (1) · Multiple Sclerosis (1) · Neuritis (1) · Spinal Cord Diseases (1) · Urinary Bladder, Neurogenic (1) · Vasculitis (1) · Virus Diseases (1)
Central Nervous System Diseases (23) · Central Nervous System Infections (23) · Deltaretrovirus Infections (23) · Infections (23) · Myelitis (23) · Nervous System Diseases (23) · Neuroinflammatory Diseases (23) · RNA Virus Infections (23) · Retroviridae Infections (23) · Spinal Cord Diseases (22) · Virus Diseases (22) · HTLV-I Infections (14) · Immune System Diseases (9) · Immunologic Deficiency Syndromes (9) · Hematologic Diseases (4)
Raltegravir Potassium (2) · Valproic Acid (2) · Adrenal Cortex Hormones (1) · Behavior Therapy (1) · Cyclosporine (1) · Electric Stimulation Therapy (1) · Exercise (1) · Hu-Mik-beta-1 monoclonal antibody (1) · Infliximab (1) · Musculoskeletal Manipulations (1) · Pentoxifylline (1) · Rituximab (1) · Sodium Chloride (1) · Tenofovir (1) · Zidovudine (1)
National Institute of Neurological Disorders and Stroke (NINDS) (6) · Imperial College London (3) · MP Biomedicals, LLC (3) · Hospital Universitário Professor Edgard Santos (2) · Carlos Brites (1) · First Affiliated Hospital of Fujian Medical University (1) · Kyowa Kirin Co., Ltd. (1) · St. Marianna University School of Medicine (1) · Tanabe Pharma Corporation (1) · Universidad Peruana Cayetano Heredia (1) · Universidade Metodista de Piracicaba (1) · University Hospital Pierre Zobda-Quitman (1) · University of Sao Paulo (1)
United States (9) · Brazil (5) · Japan (3) · United Kingdom (3) · China (1) · Peru (1)
Steven Jacobson, Ph.D. (3) · Susan Stramer, Ph.D (2) · Carlos Brites, MD, PhD (1) · Davi Costa, MD (1) · Edgar M Carvalho, MD, PhD (1) · Eduardo Gotuzzo, MD (1) · Graham P Taylor (1) · Graham P Taylor, FRCP (1) · Graham P Taylor, MD (1) · Rosana Andrade, Master (1) · Sara Dionne, PhD (1)
PMID 12522449, PMID 15472843, PMID 16984654, PMID 17376384, PMID 17717136, PMID 19578703, PMID 20573027, PMID 21343468, PMID 21965433, PMID 22227566, PMID 22720101, PMID 32692782, PMID 32986997, PMID 34562313, PMID 38430272, PMID 39186315, PMID 7760890, PMID 9180608