18 completed, 6 terminated, 3 recruiting, 3 unknown. 10 Phase 2, 6 Phase 3, 4 Not applicable, 4 Phase 1, 2 Early Phase 1.
Follow HTLV-I Infections: new trials by email Literature Review of HTLV-I Infections trials Research Report on HTLV-I Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dolutegravir Versus Dolutegravir in Combination With Tenofovir for the Treatment of HTLV-1 Infection Combination of Dolutegravir + Tenofovir DF for treatment of HTLV-1 infection, Dolutegravir (DTG) - HTLV-1 Infection, HTLV I Associated Myelopathies | Phase 2 | Recruiting | Carlos Brites | 146 | 2026-05-07 | 2026-06-02 |
| A Clinical Pharmacological Study of MT-3921 in Subjects With HTLV-1 Associated Myelopathy (HAM) MT-3921, Placebo - HTLV-1-Associated Myelopathy (HAM) | Phase 1 | Completed | Tanabe Pharma Corporation | 15 | 2022-05-02 | 2024-01-29 |
| Clinico-biological Characterization and Survival of Patients With Adult T-cell Leukemia / Lymphoma (ATL) and Patients Chronically Infected With the HTLV-1 Virus (HTLV-OBS) Lymphoproliferation Induced by HTLV-1, HTLV-1 Adult T-cell Lymphoma / Leukemia | Active not recruiting | Assistance Publique - Hôpitaux de Paris | 69 | 2022-03-23 | 2026-03-25 | |
| Testing the Addition of an Anti-cancer Drug, Lenalidomide, to the Usual Combination Chemotherapy Treatment ("EPOCH") for Adult T-Cell Leukemia-Lymphoma (ATLL) Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography - Acute Adult T-Cell Leukemia/Lymphoma, Adult T-Cell Leukemia/Lymphoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 30 | 2021-08-31 | 2026-10-15 |
| Rehabilitation in Patients With Human Lymphotropic Virus Type I Inspiratory muscle trainning, Exercise - Human T-Lymphotropic Virus Type 1 Associated Myelopathy | Not applicable | Unknown | Universidade Metodista de Piracicaba | 40 | 2021-04-27 | 2021-05-06 |
| Rituximab for HTLV-1-associated Myelopathy Rituximab - HTLV-1-associated Myelopathy | Phase 2 | Unknown | First Affiliated Hospital of Fujian Medical University | 100 | 2019-08-15 | 2022-04-19 |
| Electromiography Study in the Respiratory Muscle Training in Human Lymphotropic Virus Type 1 Rehabilitation - HTLV-I Infections | Not applicable | Completed | Universidade Metodista de Piracicaba | 20 | 2019-01-30 | 2020-08-13 |
| MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study MP Diagnostics HTLV Blot 2.4 - HTLV-I Infections, HTLV-II Infections | Phase 4 | Completed | MP Biomedicals, LLC | 150 | 2018-01-15 | 2018-09-13 |
| Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection "Raltegravir" and "Zidovudine" - HTLV-I Infections, Tropical Spastic Paraparesis | Early Phase 1 | Completed | Universidad Peruana Cayetano Heredia | 10 | 2017-07-01 | 2019-05-22 |
| A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) KW-0761 0.3 mg/kg IV, Placebo (saline) - HTLV-1 Associated Myelopathy | Phase 3 | Terminated | Kyowa Kirin Co., Ltd. | 66 | 2017-05-22 | 2022-04-14 |
| Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Laboratory Biomarker Analysis, Nivolumab - Blastic Plasmacytoid Dendritic Cell Neoplasm, Hepatosplenic T-Cell Lymphoma | Phase 2 | Terminated | Mayo Clinic | 12 | 2017-05-17 | 2020-04-21 |
| Dual Algorithm Post Market Clinical Study MP Diagnostics HTLV Blot 2.4 - HTLV-I Infections, HTLV-II Infections | Completed | MP Biomedicals, LLC | 100 | 2017-03-01 | 2017-06-12 | |
| Nivolumab in Treating Patients With HTLV-Associated T-Cell Leukemia/Lymphoma Laboratory Biomarker Analysis, Nivolumab, Pharmacogenomic Study - Acute Adult T-Cell Leukemia/Lymphoma, Adult T-Cell Leukemia/Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 3 | 2017-02-23 | 2025-03-14 |
| Raltegravir for HAM/TSP Raltegravir - HTLV-I Infection | Early Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 19 | 2013-09-05 | 2023-03-30 |
| Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 HTLV-I Infections | Completed | University Hospital Center of Martinique | 155 | 2013-05-13 | 2018-03-21 | |
| Urological Physical Therapy in HTLV-1 With Urinary Symptoms Urological physical therapy - Tropical Spastic Paraparesis, HTLV-1 | Not applicable | Completed | Hospital Universitário Professor Edgard Santos | 20 | 2012-03-01 | 2018-10-05 |
| Evaluation of the MP Diagnostics HTLV Blot 2.4 CDPHL Algorithm - HTLV-I Infections, HTLV-II Infections | Unknown | MP Biomedicals, LLC | 600 | 2011-11-01 | 2011-11-08 | |
| Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Tamibarotene - HTLV-I-Associated Myelopathy | Phase 2 / Phase 3 | Terminated | St. Marianna University School of Medicine | 15 | 2011-01-01 | 2026-10-08 |
| Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Pentoxifylline, Placebo - HTLV-1, Tropical Spastic Paraparesis | Phase 3 | Completed | Hospital Universitário Professor Edgard Santos | 48 | 2009-09-01 | 2015-03-18 |
| The HAM Infliximab Study Infliximab - HTLV-I-associated Myelopathy | Phase 2 | Terminated | Imperial College London | 3 | 2008-10-01 | 2013-04-15 |
Showing 20 of 31. Sign in to see all of them.
Paraparesis, Tropical Spastic (23) · Leukemia-Lymphoma, Adult T-Cell (5) · Lymphoma (4) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (4) · HTLV-II Infections (3) · Blastic Plasmacytoid Dendritic Cell Neoplasm (1) · Diabetes Mellitus, Insulin-Dependent, 10 (1) · Enteropathy-Associated T-Cell Lymphoma (1) · Epstein-Barr Virus Infections (1) · Herpesviridae Infections (1) · Immune System Diseases (1) · Immunoblastic Lymphadenopathy (1) · Leukemia (1) · Leukemia, T-Cell (1)
Deltaretrovirus Infections (31) · Infections (31) · RNA Virus Infections (31) · Retroviridae Infections (31) · Virus Diseases (30) · Central Nervous System Diseases (23) · Central Nervous System Infections (23) · Myelitis (23) · Nervous System Diseases (23) · Neuroinflammatory Diseases (23) · Spinal Cord Diseases (22) · Immune System Diseases (17) · Immunologic Deficiency Syndromes (17) · Hematologic Diseases (10)
Valproic Acid (3) · Nivolumab (2) · Raltegravir Potassium (2) · Zidovudine (2) · Adrenal Cortex Hormones (1) · Behavior Therapy (1) · Biopsy (1) · Cyclophosphamide (1) · Cyclosporine (1) · Daclizumab (1) · Doxorubicin (1) · Electric Stimulation Therapy (1) · Etoposide (1) · Exercise (1) · Hu-Mik-beta-1 monoclonal antibody (1)
National Institute of Neurological Disorders and Stroke (NINDS) (6) · Imperial College London (3) · MP Biomedicals, LLC (3) · National Cancer Institute (NCI) (3) · Hospital Universitário Professor Edgard Santos (2) · Universidade Metodista de Piracicaba (2) · Assistance Publique - Hôpitaux de Paris (1) · Carlos Brites (1) · First Affiliated Hospital of Fujian Medical University (1) · Kyowa Kirin Co., Ltd. (1) · Mayo Clinic (1) · St. Marianna University School of Medicine (1) · Tanabe Pharma Corporation (1) · Universidad Peruana Cayetano Heredia (1) · University Hospital Center of Martinique (1)
United States (14) · Brazil (6) · Japan (3) · United Kingdom (3) · China (1) · France (1) · Martinique (1) · Peru (1)
Steven Jacobson, Ph.D. (3) · Lee Ratner (2) · Susan Stramer, Ph.D (2) · Carlos Brites, MD, PhD (1) · Davi Costa, MD (1) · Edgar M Carvalho, MD, PhD (1) · Eduardo Gotuzzo, MD (1) · Graham P Taylor (1) · Graham P Taylor, FRCP (1) · Graham P Taylor, MD (1)
PMID 12522449, PMID 15472843, PMID 16984654, PMID 17376384, PMID 17717136, PMID 19578703, PMID 19618340, PMID 20573027, PMID 21343468, PMID 21965433, PMID 22227566, PMID 22720101, PMID 25759588, PMID 25885668, PMID 29095831, PMID 29128525, PMID 31467059, PMID 32692782, PMID 32986997, PMID 34562313, PMID 35750419, PMID 38430272, PMID 39186315, PMID 42843318, PMID 7760890, PMID 9180608
UM1CA186704 (2), P01CA128115 (1), P30CA015083 (1), UM1CA186689 (1)