9 completed, 4 terminated, 2 withdrawn, 1 enrolling by invitation. 18 Phase 1, 11 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 9, Terminated 4, Withdrawn 2, Enrolling by invitation 1, Recruiting 1, Unknown 1 |
| Phase 2 | 11 | Completed 5, Terminated 3, Withdrawn 2, Unknown 1 |
Follow Panuveitis: new trials by email Literature Review of Panuveitis trials Research Report on Panuveitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants REGN7041 - Active Noninfectious Uveitis Affecting the Posterior Segment | Phase 1 / Phase 2 | Terminated | Regeneron Pharmaceuticals | 1 | 2025-12-17 | 2026-08-17 |
| Phase 1b Long-term Extension Trial of RAY121 in Immunological Diseases (RAINBOW-LTE Trial) RAY121 - Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP) | Phase 1 | Enrolling by invitation | Chugai Pharmaceutical | 144 | 2024-12-09 | 2026-07-17 |
| Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial) RAY121 - Antiphospholipid Syndrome (APS), Bullous Pemphigoid (BP) | Phase 1 | Recruiting | Chugai Pharmaceutical | 144 | 2024-08-19 | 2026-07-22 |
| Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis 8% Dexamethasone Sodium Phosphate - Visulex, 15% Dexamethasone Sodium Phosphate - Visulex, Prednisolone Acetate (1%) Eye Drops - Non-Infectious Anterior Uveitis | Phase 1 / Phase 2 | Completed | Aciont Inc | 44 | 2014-10-01 | 2017-04-27 |
| Safety and Preliminary Efficacy Study of V404 PDS in Uveitis V404 - Uveitis, Posterior, Uveitis, Intermediate | Phase 1 / Phase 2 | Terminated | Forsight Vision4 | 7 | 2014-04-01 | 2016-12-09 |
| Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study Tocilizumab - Intermediate Uveitis, Posterior Uveitis | Phase 1 / Phase 2 | Unknown | University of Nebraska | 36 | 2013-03-01 | 2017-04-28 |
| Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis triamcinolone acetonide (Triesence®) - Uveitis, Intermediate Uveitis | Phase 1 / Phase 2 | Completed | Clearside Biomedical, Inc. | 11 | 2013-02-01 | 2021-02-21 |
| Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study Intravitreal Infliximab - Behçet's Disease, Uveitis | Phase 1 / Phase 2 | Completed | Cairo University | 20 | 2013-01-01 | 2015-12-03 |
| Anakinra for Behcet s Disease Anakinra - Autoimmune Connective Tissue Disorder, Immune System Diseases | Phase 1 / Phase 2 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 6 | 2011-09-01 | 2017-05-12 |
| Topical Interferon Gamma for Macular Edema Secondary to Uveitis Interferon Gamma-1b - Anterior Uveitis, Uveitis | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 5 | 2011-06-01 | 2012-10-08 |
| Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate Methotrexate - Non-infectious Intermediate and Posterior Uveitis | Phase 1 / Phase 2 | Terminated | National Eye Institute (NEI) | 2 | 2011-02-01 | 2019-03-27 |
| A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease XOMA 052 - Muckle Wells Syndrome, Autoinflammatory | Phase 1 / Phase 2 | Withdrawn | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 2010-08-27 | 2017-07-02 | |
| Sirolimus as Therapeutic Approach to Uveitis Sirolimus (rapamycin) - Uveitis, Intermediate Uveitis | Phase 1 | Completed | Johns Hopkins University | 30 | 2009-07-01 | 2018-08-20 |
| Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Sirolimus - Anterior Uveitis | Phase 1 | Completed | National Eye Institute (NEI) | 5 | 2009-04-01 | 2017-07-02 |
| Stem Cell Transplantation in Ocular Lesions of Behcet's Disease Autologous Stem Cell Transplantation - Retinitis, Behcet's Syndrome | Phase 1 | Terminated | Tehran University of Medical Sciences | 5 | 2007-12-01 | 2015-11-10 |
| A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Iontophoresis second generation Eyegate II device - Uveitis | Phase 1 / Phase 2 | Withdrawn | Asociación para Evitar la Ceguera en México | 2007-09-01 | 2024-05-30 | |
| Prophylactic Anecortave Acetate in Patients With a Retisert Implant anecortave acetate - Uveitis, Posterior, Glaucoma | Phase 1 | Completed | Texas Retina Associates | 12 | 2006-09-01 | 2012-06-05 |
| The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Chicken type II collagen - Arthritis, Juvenile Rheumatoid, Uveitis | Phase 1 | Completed | National Eye Institute (NEI) | 13 | 1997-07-01 | 2008-03-04 |
Uveitis (12) · Uveitis, Posterior (8) · Behcet Syndrome (6) · Uveitis, Intermediate (6) · Uveitis, Anterior (4) · Antiphospholipid Syndrome (2) · Dermatomyositis (2) · Inflammation (2) · Macular Edema (2) · Pemphigoid, Bullous (2) · Purpura, Thrombocytopenic, Idiopathic (2) · Arthritis, Juvenile (1) · Autoimmune Diseases (1) · Choroidal Effusions (1)
Eye Diseases (18) · Uveal Diseases (18) · Skin and Connective Tissue Diseases (8) · Cardiovascular Diseases (7) · Skin Diseases (7) · Skin Diseases, Vascular (7) · Uveitis, Anterior (7) · Vascular Diseases (7) · Vasculitis (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Genetic Diseases, Inborn (6) · Hereditary Autoinflammatory Diseases (6) · Immune System Diseases (6) · Mouth Diseases (6)
Methotrexate (2) · Sirolimus (2) · Adrenal Cortex Hormones (1) · Interleukin 1 Receptor Antagonist Protein (1) · Ophthalmic Solutions (1) · Triamcinolone (1) · Triamcinolone Acetonide (1) · anecortave acetate (1) · gevokizumab (1) · interferon gamma-1b (1) · prednisolone acetate (1) · tocilizumab (1)
National Eye Institute (NEI) (4) · Chugai Pharmaceutical (2) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (2) · Aciont Inc (1) · Asociación para Evitar la Ceguera en México (1) · Cairo University (1) · Clearside Biomedical, Inc. (1) · Forsight Vision4 (1) · Johns Hopkins University (1) · Regeneron Pharmaceuticals (1) · Tehran University of Medical Sciences (1) · Texas Retina Associates (1) · University of Nebraska (1)
United States (14) · Australia (2) · Austria (2) · Bulgaria (2) · Canada (2) · Croatia (2) · Czechia (2) · France (2) · Germany (2) · Hungary (2) · Italy (2) · Japan (2) · Netherlands (2) · Norway (2) · Poland (2)
Quan D Nguyen, MD, MSc (2) · Behrouz Nikbin, MD (1) · David G Callanan, MD (1) · Fereydoun Davatchi, MD (1) · Hatice N Sen, M.D. (1) · Hatice Nida Sen, MD, MHSc (1) · Hormoz Shams, MD (1) · Hugo Quiroz-Mercado, MD (1) · Lourdes Arellanes, MD (1) · Mahmoud Soliman, MD PhD (1) · Peter C Grayson, M.D. (1) · Raul Velez-Montoya, MD (1) · Thomas Ciulla, MD (1)
PMID 22465364, PMID 23773637, PMID 25918559, PMID 27980877, PMID 28335798, PMID 33042579
2025 (1), R44EY014772 (1)