164 completed. 164 Phase 1, 29 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 164 | Completed 164 |
| Phase 2 | 29 | Completed 29 |
Follow Neuroblastoma: new trials by email Literature Review of Neuroblastoma trials Research Report on Neuroblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTA0-Tyr3-Octreotate in Children With Refractory or Recurrent Neuroblastoma Expressing Somatostatin Receptors. PRRT with 177Lu-DOTATATE - Neuroblastoma | Phase 1 | Completed | Institut Claudius Regaud | 1 | 2023-04-17 | 2026-04-29 |
| Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Neuroblastoma: A Single-arm, Phase I/II，Multi-center, Clinical Study. Apatinib, Irinotecan, Temozolomide - Neuroblastoma | Phase 1 / Phase 2 | Completed | Sun Yat-sen University | 125 | 2021-08-26 | 2026-09-10 |
| TEMOkids Study : A Phase I Pediatric Study for KIMOZO, Oral Suspension of Temozolomide Temozolomide Oral Suspension - Pediatric Cancer | Phase 1 | Completed | Orphelia Pharma | 49 | 2021-03-16 | 2025-07-31 |
| A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma Abemaciclib, Irinotecan, Temozolomide - Relapsed Solid Tumor, Refractory Solid Tumor | Phase 1 / Phase 2 | Completed | Eli Lilly and Company | 47 | 2020-11-09 | 2026-03-02 |
| Indocyanine Green (ICG) Guided Tumor Resection Indocyanine Green - Neoplastic Disease, Solid Tumor | Phase 1 | Completed | St. Jude Children's Research Hospital | 215 | 2020-02-07 | 2026-09-14 |
| Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitors BMS-986158 and BMS-986378 in Pediatric Cancer BMS-986158, BMS-986378 - Solid Tumor, Childhood, Lymphoma | Phase 1 | Completed | Dana-Farber Cancer Institute | 41 | 2019-09-27 | 2024-10-02 |
| MIBG With Dinutuximab +/- Vorinostat 131I-MIBG, Dinutuximab, Vorinostat - Neuroblastoma | Phase 1 | Completed | New Approaches to Neuroblastoma Therapy Consortium | 45 | 2018-09-12 | 2025-04-16 |
| Nab-paclitaxel in Combination with Gemcitabine for Pediatric Relapsed and Refractory Solid Tumors Gemcitabine, Nab-paclitaxel - Cancer | Phase 1 | Completed | Emory University | 24 | 2018-08-27 | 2024-10-04 |
| Oral Liquid 13-cis-retinoic Acid (13-CRA) Liquid 13-Cis Retinoic Acid, Extracted capsules 13-CRA - Neuroblastoma | Phase 1 / Phase 2 | Completed | Nova Laboratories Limited | 20 | 2018-04-17 | 2021-10-19 |
| A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies chemotherapy, venetoclax - Malignancies, Acute Lymphoblastic Leukemia (ALL) | Phase 1 | Completed | AbbVie | 143 | 2017-11-08 | 2023-05-22 |
| NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922) Lorlatinib, Cyclophosphamide, Topotecan - Neuroblastoma | Phase 1 | Completed | New Approaches to Neuroblastoma Therapy Consortium | 65 | 2017-09-05 | 2025-09-15 |
| Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors Enoblituzumab - Neuroblastoma, Rhabdomyosarcoma | Phase 1 | Completed | MacroGenics | 25 | 2016-12-01 | 2022-02-08 |
| Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma CUDC-907 - Lymphoma, Neuroblastoma | Phase 1 | Completed | Dana-Farber Cancer Institute | 26 | 2016-10-01 | 2026-02-11 |
| A Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma TB-403 20mg/kg, TB-403 50mg/kg, TB-403 100mg/kg - Relapsed or Refractory Medulloblastoma (MB), Neuroblastoma (NB), Ewing Sarcoma (ES) and Alveolar Rhabdomyosarcoma (ARMS) | Phase 1 | Completed | Oncurious NV | 18 | 2016-05-01 | 2021-01-13 |
| A Phase I Trial of Anti-GD2 T-cells (1RG-CART) Leukapheresis, Cyclophosphamide, Fludarabine - Relapsed or Refractory Neuroblastoma | Phase 1 | Completed | Cancer Research UK | 17 | 2016-02-29 | 2021-08-17 |
| Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors Abemaciclib - Diffuse Intrinsic Pontine Glioma, Brain Tumor, Recurrent | Phase 1 | Completed | Emory University | 53 | 2016-02-01 | 2023-10-26 |
| Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma cyclophosphamide, NK cells, hu3F8 - Neuroblastoma, High-Risk | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 85 | 2016-01-05 | 2025-07-30 |
| Anti-GD2 4th Generation CART Cells Targeting Refractory and/or Recurrent Neuroblastoma Anti-GD2 CART - Neuroblastoma, Effects of Immunotherapy | Phase 1 | Completed | Zhujiang Hospital | 12 | 2016-01-01 | 2024-03-15 |
| Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas Ipilimumab, Laboratory Biomarker Analysis, Nivolumab - Metastatic Melanoma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 140 | 2015-03-30 | 2023-10-17 |
| Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors Simvastatin, Cyclophosphamide, Topotecan - Retinoblastoma, Clear Cell Sarcoma | Phase 1 | Completed | Emory University | 13 | 2015-02-01 | 2020-04-03 |
Showing 20 of 164. Sign in to see all of them.
Osteosarcoma (34) · Sarcoma (34) · Wilms Tumor (33) · Medulloblastoma (29) · Rhabdomyosarcoma (27) · Neoplasms (25) · Astrocytoma (23) · Esthesioneuroblastoma, Olfactory (23) · Neuroectodermal Tumors, Primitive, Peripheral (21) · Sarcoma, Ewing (21) · Squamous Cell Carcinoma of Head and Neck (21) · Brain Neoplasms (20) · Breast Neoplasms (20) · Recurrence (20)
Neoplasms by Histologic Type (164) · Neoplasms, Glandular and Epithelial (164) · Neoplasms, Nerve Tissue (164) · Neoplasms, Neuroepithelial (164) · Neuroectodermal Tumors (164) · Neuroectodermal Tumors, Primitive (159) · Neoplasms, Germ Cell and Embryonal (158) · Neuroectodermal Tumors, Primitive, Peripheral (143) · Neoplasms (139) · Neoplasms by Site (85) · Neoplasms, Connective and Soft Tissue (65) · Nervous System Diseases (56) · Female Urogenital Diseases (53) · Female Urogenital Diseases and Pregnancy Complications (53) · Urogenital Diseases (53)
Filgrastim (21) · Cyclophosphamide (20) · Irinotecan (14) · Peripheral Blood Stem Cell Transplantation (12) · Etoposide (11) · Granulocyte Colony-Stimulating Factor (11) · Melphalan (11) · Carboplatin (10) · Vincristine (10) · Temozolomide (9) · Topotecan (9) · 3-Iodobenzylguanidine (7) · Cisplatin (7) · Interleukin-2 (7) · Isotretinoin (7)
National Cancer Institute (NCI) (30) · Memorial Sloan Kettering Cancer Center (16) · New Approaches to Neuroblastoma Therapy Consortium (15) · Children's Oncology Group (11) · St. Jude Children's Research Hospital (9) · National Institutes of Health Clinical Center (CC) (6) · Baylor College of Medicine (5) · Emory University (4) · Fred Hutchinson Cancer Center (3) · Novartis Pharmaceuticals (3) · Cancer Research UK (2) · Case Comprehensive Cancer Center (2) · Children's Mercy Hospital Kansas City (2) · City of Hope Medical Center (2) · Dana-Farber Cancer Institute (2)
United States (148) · Canada (22) · Australia (13) · United Kingdom (13) · France (12) · Germany (8) · Italy (7) · Spain (7) · Netherlands (6) · South Korea (3) · Switzerland (3) · Belgium (2) · China (2) · Argentina (1) · Austria (1)
Shakeel Modak, MD (4) · Giselle Sholler, MD (3) · Katherine K. Matthay, MD (3) · Nai-Kong V. Cheung, MD, PhD (3) · Steven DuBois, MD (3) · Barry J. Maurer, MD, PhD (2) · Brian H. Kushner, MD (2) · Darell D. Bigner, MD, PhD (2) · Elizabeth Fox, MD (2) · Holly Meany, MD (2) · John M. Maris, MD (2) · Julie R. Park, MD (2) · Kenneth G. Lucas, MD (2) · Rosandra N Kaplan, M.D. (2)
PMID 31401903, PMID 41920422, PMID 14767498, PMID 15033677, PMID 15814645, PMID 16234526, PMID 16421427, PMID 16551859, PMID 16849757, PMID 16914576, PMID 18048828, PMID 18281544, PMID 18470481, PMID 18974373, PMID 19075272, PMID 19171709, PMID 19171714, PMID 19430790, PMID 19805691, PMID 20044751, PMID 20049927, PMID 20145168, PMID 20407240, PMID 20460632, PMID 20847174, PMID 21343563, PMID 21984804, PMID 22010014, PMID 23598171, PMID 23868427, PMID 24457244, PMID 24520094, PMID 24711551, PMID 25452614, PMID 25965900, PMID 26018967, PMID 26062933, PMID 26154941, PMID 26611425, PMID 28032129, PMID 28153957, PMID 29181270, PMID 29595064, PMID 30093449, PMID 30697903, PMID 30850872, PMID 31876107, PMID 32127657, PMID 32169872, PMID 32192573
P01CA081403 (12), P30CA008748 (4), U01CA097452 (4), UM1CA097452 (4), P30CA043703 (2), U01CA069856 (2), U10CA098543 (2), U10CA180886 (2), 2005 (1), 2014 (1), 2017 (1), 2019 (1), 2023 (1), P01CA217959 (1), P30CA016087 (1)