3 completed, 2 recruiting, 1 terminated, 1 withdrawn. 3 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow MSI: new trials by email Literature Review of MSI trials Research Report on MSI
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer Tumor samples will be tested for mutation status of KRAS, NRAS, BRAF, HER2 and MSI - Colorectal Cancer Metastatic, Brain Metastases, Adult | Recruiting | Blokhin's Russian Cancer Research Center | 30 | 2024-04-01 | 2026-10-05 | |
| Monalizumab and MEDI5752 in Patients With MSI and/or dMMR Metastatic Cancer Monalizumab/MEDI5257 - MSI, dMMR Colorectal Cancer | Phase 2 | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2023-12-01 | 2026-04-06 | |
| Relationship of EBV-positive Gastric Cancer and Multiple Genes Associated With Gastric Carcinogenesis Gastrectomy - Gastric Cancer, EBV Infection | Completed | Saint Vincent's Hospital, Korea | 460 | 2022-08-03 | 2022-11-03 | |
| Prospective Multicenter Registry Study to Assess the Frequency of Lynch Syndrome Among Patients With Colorectal Cancer Colorectal Cancer, Lynch Syndrome | Recruiting | State Scientific Centre of Coloproctology, Russian Federation | 2500 | 2022-08-01 | 2022-10-25 | |
| A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies INCAGN02390 - Cervical Cancer, Gastric Cancer | Phase 1 | Completed | Incyte Corporation | 40 | 2018-09-24 | 2021-11-15 |
| Standard Chemotherapy vs Immunotherapie in 2nd Line Treatment of MSI Colorectal Mestastatic Cancer FOLFOX regimen, FOLFIRI Protocol, Avelumab - Metastatic Colorectal Cancer, MSI | Phase 2 | Completed | Federation Francophone de Cancerologie Digestive | 132 | 2018-04-24 | 2025-06-29 |
| Study With Atezolizumab Plus Bevacizumab in Patients With Chemotherapy Resistant, MSI-like, Colorectal Cancer Atezolizumab, Bevacizumab - MSI, ColoRectal Cancer | Phase 2 | Terminated | Vall d'Hebron Institute of Oncology | 46 | 2017-11-24 | 2025-10-01 |
Colorectal Neoplasms (3) · Stomach Neoplasms (2) · Activated Protein C Resistance (1) · Brain Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Merkel Cell (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Renal Cell (1) · Carcinoma, Transitional Cell (1) · Colorectal Neoplasms, Hereditary Nonpolyposis (1) · Epstein-Barr Virus Infections (1) · Esophageal Neoplasms (1) · Melanoma (1) · Mesothelioma (1) · Neoplasms (1)
Neoplasms (6) · Neoplasms by Site (6) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Gastrointestinal Diseases (5) · Gastrointestinal Neoplasms (5) · Colonic Diseases (3) · Intestinal Diseases (3) · Intestinal Neoplasms (3) · Rectal Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · DNA Virus Infections (2) · Genetic Diseases, Inborn (2) · Infections (2) · Stomach Diseases (2)
Bevacizumab (2) · Cetuximab (1) · Folfox protocol (1) · Gastrectomy (1) · Genes, mos (1) · IFL protocol (1) · Panitumumab (1) · aflibercept (1) · atezolizumab (1) · avelumab (1) · monalizumab (1)
Assistance Publique - Hôpitaux de Paris (1) · Blokhin's Russian Cancer Research Center (1) · Federation Francophone de Cancerologie Digestive (1) · Incyte Corporation (1) · Saint Vincent's Hospital, Korea (1) · State Scientific Centre of Coloproctology, Russian Federation (1) · Vall d'Hebron Institute of Oncology (1)
France (2) · Russia (2) · Belgium (1) · Italy (1) · Netherlands (1) · South Korea (1) · Spain (1) · United States (1)
Alexey Tryakin, MD, professor (1) · Alexey Tsukanov, PhD (1) · Ali Bekyashev, MD, professor (1) · Anna Stroganova, MD (1) · Josep Tabernero Caturla, Prof (1) · Julien Taieb, Pr (1) · Kyong Hwa Jun, Ph.D. (1) · Nawel Bourayou, MD (1)
PMID 37535388, PMID 40531517, PMID 42682457
2016 (1)