3 recruiting, 1 completed. 4 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Recruiting 3, Completed 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow MPNST: new trials by email Literature Review of MPNST trials Research Report on MPNST
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas Selumetinib + ZEN-3694 ± Durvalumab - MPNST, NF1 | Phase 2 | Recruiting | University of Alabama at Birmingham | 41 | 2026-08-04 | 2026-08-24 |
| Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor BMS-986504 - Malignant Peripheral Nerve Sheath Tumors, MPNST | Phase 1 / Phase 2 | Recruiting | Ankit Mangla, MD | 17 | 2026-08-01 | 2026-08-11 |
| A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors Selinexor - Wilms Tumor, Rhabdoid Tumor | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 45 | 2023-08-01 | 2026-10-23 |
| SARC016: Study of Everolimus With Bevacizumab to Treat Refractory Malignant Peripheral Nerve Sheath Tumors everolimus, bevacizumab - Malignant Peripheral Nerve Sheath Tumors, MPNST | Phase 2 | Completed | Sarcoma Alliance for Research through Collaboration | 25 | 2012-09-01 | 2019-03-06 |
Neurofibrosarcoma (4) · Sarcoma (2) · Neurofibromatosis 1 (1) · Rhabdoid Tumor (1) · Wilms Tumor (1)
Fibrosarcoma (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Neoplasms, Connective Tissue (4) · Neoplasms, Connective and Soft Tissue (4) · Neoplasms, Fibrous Tissue (4) · Neoplasms, Nerve Tissue (4) · Nerve Sheath Neoplasms (4) · Nervous System Diseases (4) · Nervous System Neoplasms (4) · Neurofibroma (4) · Neuromuscular Diseases (4) · Peripheral Nervous System Diseases (4) · Peripheral Nervous System Neoplasms (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2)
AZD 6244 (1) · Bevacizumab (1) · Everolimus (1) · selinexor (1)
Ankit Mangla, MD (1) · Memorial Sloan Kettering Cancer Center (1) · Sarcoma Alliance for Research through Collaboration (1) · University of Alabama at Birmingham (1)
United States (4)
Ankit Mangla, MD (1) · Brigitte C. Widemann, MD (1) · Michael Ortiz, MD (1)