15 completed, 3 not yet recruiting, 3 recruiting, 2 unknown. 20 Not applicable, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 20 | Completed 13, Not yet recruiting 3, Recruiting 2, Unknown 2 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Modified Radical Mastectomy: new trials by email Literature Review of Modified Radical Mastectomy trials Research Report on Modified Radical Mastectomy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial Evaluating the Analgesic Efficacy of Magnesium Sulfate as an Adjuvant to Bupivacaine in Local Wound Infiltration for Patients Undergoing Modified Radical Mastectomy (MRM) With Axillary Clearance Magnesium Sulfate 750 mg with Bupivacaine 0.5% for Local Wound Infiltration, Bupivacaine 0.5% + Normal Saline - Modified Radical Mastectomy | Not applicable | Not yet recruiting | King Hussein Cancer Center | 70 | 2026-09-01 | 2026-08-31 |
| Comparıson of Analgesıc Effıcacy of Dıfferent Volumes of Serratus Posterior Superıor Intercostal Plane Block After Modıfıed Radıcal Mastectomy Surgery Serratus Posterior Superior Intercostal Plane (SPSIP) block 40 ml of 0.1875% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 50 ml of 0.15% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 30 ml of 0.25% bupivacaine - Modified Radical Mastectomy, Post Operative Pain, Acute | Not applicable | Not yet recruiting | Cumhuriyet University | 90 | 2026-08-25 | 2026-08-25 |
| Subtransverse Interligamentary Block Versus Paravertebral Block for Quality of Recovery After Mastectomy Subtransverse interligamentary plane block (STIL), Thoracic paravertebral block (TPVB) - Quality of Recovery (QoR-15), Modified Radical Mastectomy | Not applicable | Recruiting | Tanta University | 60 | 2026-06-20 | 2026-08-04 |
| Adding Magnesium Sulfate to Combined Pecto-Intercostal & Serratus Anterior Planes Block on Post-operative Analgesia in Patients Undergoing Modified Radical Mastectomy combined Pecto-Intercostal- Serratus anterior fascial planes Block - Modified Radical Mastectomy | Not applicable | Not yet recruiting | South Egypt Cancer Institute | 100 | 2026-02-15 | 2026-02-25 |
| Costotransverse Foramen Block With Erector Spinae Plane Block in Modified Radical Mastectomy Costotransverse foramen block, Erector spinae plane block - Costotransverse Foramen Block, Erector Spinae Plane Block | Not applicable | Recruiting | National Cancer Institute, Egypt | 110 | 2026-01-24 | 2026-01-27 |
| Comparison of Mean Duration of Analgesia Following the Administration of Bupivacaine With and Without Magnesium Sulphate in Ultrasound Guided Erector Spinae Plane Block in Modified Radical Mastectomy Patients Group B (bupivacaine), Bupivacaine plus magnesium sulfate - Modified Radical Mastectomy | Not applicable | Completed | Gulab Devi Hospital | 60 | 2025-05-28 | 2026-03-10 |
| Infusion of Dexmedetomidine Versus Lidocaine in Management of Acute Postoperative Pain After Modified Radical Mastectomy Dexmedetomidine, Lidocaine - Infusion, Dexmedetomidine | Not applicable | Completed | Cairo University | 40 | 2025-05-15 | 2025-09-03 |
| Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy Unilateral Erector Spinae group, Unilateral Serratus Anterior group - Modified Radical Mastectomy, Breast Cancer | Phase 3 | Recruiting | Kholoud Usama | 100 | 2025-03-03 | 2025-04-27 |
| Adding Magnesium Sulfate to Local Anesthetic in Combined Pectoral Nerve and Stellate Ganglion Block for Postoperative Pain Control After Modified Radical Mastectomy Bupivacaine, Bupivacaine + Magnesium sulfate - Magnesium Sulfate, Local Anesthetic | Not applicable | Completed | Cairo University | 70 | 2025-02-15 | 2026-05-22 |
| Mid-point Transverse Process to Pleura Block VS Serratus Anterior Plane Block for Postoperative Analgesia After Modified Radical Mastectomy Serratus Anterior Plane Block (SAPB), Midpoint transverse process to pleura (MTP) block - Modified Radical Mastectomy, Postoperative Analgesia | Not applicable | Completed | Ain Shams University | 30 | 2024-11-01 | 2026-10-07 |
| Effect of ERAS and Upper Limb Exercise on LoS After Modified Radical Mastectomy Enhanced Recovery After Surgery, Upper Limb Exercise - Modified Radical Mastectomy | Not applicable | Completed | Prof. R. D. Kandou General Hospital | 24 | 2024-10-01 | 2026-05-07 |
| Comparison of ESP and SPSIP Blocks in Breast Surgery Erector Spinae Plane Block, SPSIPB blcok, Control - Breast Surgery, Macromastia | Not applicable | Completed | Çanakkale Onsekiz Mart University | 75 | 2024-07-06 | 2025-02-06 |
| Active Drainage vs. Passive Drainage in MRM compare active and passive drain - Modified Radical Mastectomy, Drain Effect | Not applicable | Completed | MOHAMED GAMAL AHMED ARAKEEB | 157 | 2024-05-30 | 2026-06-02 |
| Perioperative Analgesic Effect of Two Different Volumes of Local Anesthetic Solution in Erector Spinae Plane Block in Patients Undergoing Modified Radical Mastectomy Erector spinae plane block(15 ml bupivacaine 0.5%), Erector spinae plane block (15 ml bupivacaine 0.5% and 15ml normal saline) - Erector Spinae Plane Block, Modified Radical Mastectomy | Not applicable | Completed | Cairo University | 52 | 2024-03-01 | 2025-05-21 |
| Preemptive Erector Spinae Plane Block Versus Serratus Anterior Plane Block in MRM Erector spinae plane group, Serratus anterior plane group - Modified Radical Mastectomy | Not applicable | Completed | Benha University | 70 | 2023-01-22 | 2024-05-08 |
| Duloxetine for Postoperative Analgesia After Modified Radical Mastectomy Acetaminophen group, Duloxetine group - Modified Radical Mastectomy, Postoperative Analgesia | Not applicable | Unknown | Tanta University | 40 | 2022-07-16 | 2022-07-20 |
| Combined PECS II and Transeversus Thoracic Plane Blocks Vs Serratus Anterior Plane Block in Modified Radical Mastectomy Pectoral nerve (PECS) block -transversus thoracic plane (TTP) block, Serratus anterior plane (SAP) block - Ultrasound-Guided, Transeversus Thoracic Plane Blocks | Not applicable | Completed | Tanta University | 70 | 2021-06-01 | 2022-11-29 |
| Ultrasound-Guided PEC I vs SAP Block for Postoperative Analgesia in Modified Radical Mastectomy Ultrasound-Guided Pectoral Nerve Block (PECS I), Ultrasound-Guided Serratus Anterior Plane Block (SAPB) - Breast Cancer, Modified Radical Mastectomy | Not applicable | Completed | Ain Shams University | 32 | 2021-05-03 | 2026-02-05 |
| Effectiveness of Combined Erector Spinae and Pecto-intercostal Fascial Plane Blocks Versus Thoracic Paravertebral Block in Perioperative Pain in Modified Radical Mastectomy Bupivacaine Hydrochloride, Dexamethasone phosphate - Modified Radical Mastectomy | Phase 4 | Completed | Kasr El Aini Hospital | 30 | 2021-03-12 | 2023-03-13 |
| Different Volumes and Equivalent Concentrations of Bupivacaine in Erector Spinae Plane Block in Modified Radical Mastectomy Erector spinae plane block with 10 ml of 0.25% isobaric bupivacaine, Erector spinae plane block with 20 ml of 0.25% isobaric bupivacaine - Equivalent Concentrations, Different Volumes | Not applicable | Completed | Mansoura University | 60 | 2019-10-01 | 2026-10-13 |
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Breast Neoplasms (5) · Pain, Postoperative (3) · Agnosia (1) · Bites and Stings (1) · Gigantomastia (1) · Motor Activity (1)
Breast Diseases (5) · Neoplasms (5) · Neoplasms by Site (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Pain (3) · Pathologic Processes (3) · Postoperative Complications (3) · Behavior (1) · Chemically-Induced Disorders (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1)
Bupivacaine (6) · Dental Occlusion (3) · Magnesium Sulfate (3) · Dexmedetomidine (2) · Saline Solution (2) · Electrocoagulation (1) · Enhanced Recovery After Surgery (1) · Lead (1) · Lidocaine (1) · Second Harmonic Generation Microscopy (1) · dexamethasone 21-phosphate (1) · thiamine triphosphorate (1)
Cairo University (3) · Tanta University (3) · Ain Shams University (2) · Mansoura University (2) · Aga Khan University (1) · Benha University (1) · Cumhuriyet University (1) · Gulab Devi Hospital (1) · Kasr El Aini Hospital (1) · Kholoud Usama (1) · King Hussein Cancer Center (1) · MOHAMED GAMAL AHMED ARAKEEB (1) · National Cancer Institute, Egypt (1) · Prof. R. D. Kandou General Hospital (1) · South Egypt Cancer Institute (1)
Egypt (15) · Pakistan (2) · Turkey (Türkiye) (2) · China (1) · Indonesia (1) · Jordan (1)
Abd-Elaziz Metawa, MD (1) · Ramy Saleh, MD (1) · Shaista M Khan, FRCS (1)
PMID 24232511, PMID 31280100, PMID 31476624, PMID 31744747, PMID 32172551, PMID 33407753, PMID 33818764, PMID 36813015