8 completed, 1 active not recruiting, 1 terminated. 10 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 8, Active not recruiting 1, Terminated 1 |
Follow Malaria in Pregnancy: new trials by email Literature Review of Malaria in Pregnancy trials Research Report on Malaria in Pregnancy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy Dihydroartemisinin-Piperaquine (DP), Sulfadoxine pyrimethamine (SP) - Malaria, Malaria in Pregnancy | Phase 3 | Active not recruiting | Menzies School of Health Research | 1172 | 2022-08-31 | 2025-06-06 |
| Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG) Sulfadoxine pyrimethamine, Pyramax - Malaria in Pregnancy | Phase 3 | Completed | University of Kinshasa | 250 | 2021-05-06 | 2022-11-04 |
| Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa dihydroartemisinin-piperaquine, sulphadoxine-pyrimethamine, dihydroartemisinin-piperaquine plus azithromycin - Pregnancy, Malaria in Pregnancy | Phase 3 | Completed | Liverpool School of Tropical Medicine | 4680 | 2018-03-29 | 2022-06-27 |
| Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum cotrimoxazole daily prophylaxis, sulphadoxine-pyrimethamine - Malaria in Pregnancy, HIV Infection | Phase 3 | Completed | Institut Pasteur | 193 | 2013-12-01 | 2020-11-30 |
| Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy Cotrimoxazole prophylaxis, SP IPT - Malaria in Pregnancy, HIV Infections | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 848 | 2010-09-01 | 2013-10-24 |
| Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria Dihydroartemisinin-piperaquine, Artesunate-mefloquine, Artesunate-amodiaquine - Malaria in Pregnancy | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 3428 | 2010-06-01 | 2016-03-14 |
| Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine cotrimoxazole, mefloquine - Malaria in Pregnancy, HIV Infections | Phase 3 | Completed | Institut de Recherche pour le Developpement | 430 | 2009-12-01 | 2013-01-23 |
| Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea chloroquine, sulphadoxine pyrimethamine, LLIN, azithromycin, sulphadoxine pyrimethamine, LLIN - Malaria in Pregnancy, Sexually Transmitted Infections | Phase 3 | Completed | University of Melbourne | 2793 | 2009-11-01 | 2013-04-23 |
| Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy Cotrimoxazole, Sulfadoxine-pyrimethamine - Malaria in Pregnancy | Phase 3 | Terminated | Institute of Tropical Medicine, Belgium | 352 | 2009-02-01 | 2016-01-18 |
| New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa sulfadoxine-pyrimethamine, Chloroquine - Malaria in Pregnancy | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 2766 | 2004-03-01 | 2010-09-14 |
Malaria (7) · HIV Infections (3) · Anemia (1) · Malaria, Falciparum (1) · Malaria, Vivax (1) · Sexually Transmitted Diseases (1) · Treponemal Infections (1)
Infections (9) · Mosquito-Borne Diseases (8) · Parasitic Diseases (8) · Protozoan Infections (8) · Vector Borne Diseases (8) · Communicable Diseases (4) · Genital Diseases (4) · Urogenital Diseases (4) · Blood-Borne Infections (3) · Immune System Diseases (3) · Immunologic Deficiency Syndromes (3) · Lentivirus Infections (3) · RNA Virus Infections (3) · Retroviridae Infections (3) · Sexually Transmitted Diseases (3)
fanasil, pyrimethamine drug combination (8) · Trimethoprim, Sulfamethoxazole Drug Combination (3) · Azithromycin (2) · Chloroquine (2) · Artemether, Lumefantrine Drug Combination (1) · Mefloquine (1) · amodiaquine, artesunate drug combination (1) · pyronaridine tetraphosphate, artesunate drug combination (1)
Institute of Tropical Medicine, Belgium (4) · Institut Pasteur (1) · Institut de Recherche pour le Developpement (1) · Liverpool School of Tropical Medicine (1) · Menzies School of Health Research (1) · University of Kinshasa (1) · University of Melbourne (1)
Zambia (3) · Burkina Faso (2) · Malawi (2) · Papua New Guinea (2) · Benin (1) · Central African Republic (1) · Democratic Republic of the Congo (1) · Ghana (1) · Kenya (1) · Tanzania (1)
Christine Manyando, MD (2) · Umberto D'Alessandro, MD (2) · Alexandre Manirakiza, MD (1) · Frank Mosha, PhD (1) · Holger Unger, PhD MBChB (1) · John Lusingu, PhD (1) · Marcel D Zannou, Professor (1) · Michel Cot, MD, PHD (1) · Mirdad Kazanji (1) · Muriel Vray (1) · Pierre-Marie Girard, Professor (1) · Sheick Coulibaly Oumar Coulibaly, MD PhD (1) · Simon K Kariuki, PhD (1) · Stephen J Rogerson, FRACP PhD (1)
PMID 39324693, PMID 23945130, PMID 24830749, PMID 24996807, PMID 25591391, PMID 25592254, PMID 26006260, PMID 26088768, PMID 26286026, PMID 26962727, PMID 27895848, PMID 28103875, PMID 30922317, PMID 34181872, PMID 34607575, PMID 34627141, PMID 35156190, PMID 35619134, PMID 36443882, PMID 36913959, PMID 39985024, PMID 40018559